Journal of Biomed Research

Chimeric antigen receptor (CAR) T cells were first clinically tested in trials against metastatic solid tumors without therapeutic benefit; however, these efforts established the necessary domains that are required for a functional CAR T-cell. With the characterization of cells within the immune system, the expression of CD19 was found to dictate B cell lineage that remains present on normal and malignant B cells.

Before the discovery of insecticide chemicals most of the time the rural community living in tsetse belt areas were forced to conduct bush clearing using fires, destroy forests and forest galleries for the well-being of their and their animal’s health. Tsetse flies are vectors of trypanosomes transmitting the disease called Nagana in cattle and sleeping sickness in human in these Glossina infested or belt areas.

Expectancy-Value theory was originally proposed by John William Atkinson in the 1950s and 60s as an attempt to understand different behaviors of students including persistence, decision making when given multiple opportunities to choose from, and the effort of striving for success.

Clearly, elite soccer athletes can lose performance as the time matches comes to an end, due to fatigue, match intensity, dehydration, and also, oftentimes, due to poor nutrition or poor supply of energy through carbohydrates.

The conspecific killing of offspring by nonparental individuals occurs broadly in the animal kingdom, from invertebrates to mammals. It includes neonaticide if a neonate is killed on the first day of the birth, and infanticide if such tragedy occurs in the first year of life. As for the occurrences in mammals, they have been recorded on the rodents, artiodactyls (even-toed ungulates), carnivores, perissodactyls (odd-toed ungulates), and primates.

Exercise has been found to improve function, mitigate disability, enhance the anticancer immune system response, and improve quality of life for patients with osteosarcoma and its survivors. Of late, exercise has additionally been implemented as an adjuvant to standard therapies. These products of exercise, along with the benefits of physical activity in pre- and postoperative rehabilitation, were summarized in the recently published book chapter Exercise and Physical Activity in Patients with Osteosarcoma and Survivors.

This study aimed to investigate and identify the correlates of job satisfaction of large-scale industry employees. We randomly selected 299 employees from an oilfield in the East of China and administered a questionnaire survey. We found that when other variables controlled for, the conflict with leaders and the discontent with management was negatively related to job satisfaction, and conflict with colleagues was positively associated with job satisfaction. On the other hand, the workload was not an important influencing factor.

Anki is an open-sourced educational platform that utilizes a spaced repetition-based algorithm for information retention. This application has become increasingly popular among medical students and residents over recent years. The aim of this review was to describe this novel education technique, provide reasons for its adoption, and summarize the available literature regarding the efficacy of this method.

Chronic kidney disease (CKD) is a major risk factor for dialysis, also increases the risk of cardiovascular diseases and is closely related to lifestyle-related diseases such as diabetes mellitus and hypertension. Moreover, dialysis patients develop complications including cardiovascular diseases, infections, and malignant neoplasms and have very poor prognosis. 

Breast cancer is the most common cancer in women worldwide, with the highest mortality rates. While breast tumors can have heterogeneous biology, the mutational burden/genomic alterations, etc, are relatively less when compared to other malignancies like pancreatic cancer or glioblastomas, rendering breast tumors comparatively less aggressive.

We read with interest the article by Mert Er et al., “Physical activity and quality of life in statin users,”. The topic is clinically important given persistent concerns regarding statin-associated muscle symptoms (SAMS) and their potential impact on adherence and lifestyle behaviors. However, several conceptual and methodological considerations warrant closer examination.

Background: Hemodialysis (HD) patients experience severe physical deconditioning due to extremely low physical activity, prolonged sedentary behavior, and progressive muscle wasting. These changes accelerate frailty, impair functional independence, reduce quality of life (QoL), and increase hospitalization and mortality risks. Sarcopenia is now recognized as a key predictor of poor outcomes in this population.