Journal of Biomed Research

Commentary Open Access

Syndrome similar to Familial Hypocalciuric Hypercalcemia (FHH) produced in mice deleted of the gene encoding transient receptor potential canonical channel 1 (TRPC1)

Bonnie Eby, Alexander Ku Lau, Meghan Pantalia, Usman Khan, Kai Lau

We recently found that global deletion of TRPC1 produces phenotypes similar to FHH. These TRPC1 null mice have mildly elevated serum Ca in both fasted and unfasted conditions from 3.5 through 21.5 months of age, and inappropriately elevated parathyroid hormone (PTH) levels. They also have hypocalciuria, similar to FHH patients.

Commentary Open Access

A longing for flawless awakening from general anesthesia

Yumiko Ishizawa, Jesus J. Ballesteros

Anesthetic recovery can be a critical period since neurocognitive problems such as agitation and delirium are often seen during the early recovery phase. We recently demonstrated that an α2-adrenergic agonist dexmedetomidine-induced unconsciousness and accompanying brain dynamics changes were completely and instantly reversed by the α2-adrenergic antagonist in the nonhuman primate model.

Commentary Open Access

The ergogenic supplements recommendations also apply to the elite soccer player

Haniel Fernandes

Whilst the performance enhancement effects of ergogenic supplements have been well-established, there are only limited reports for their use in the training and performance evaluation in soccer players. Here, we summarize the results through literature research and present them in a more abstracted form for the scientific community.

Commentary Open Access

Blending into the crowd: electrophysiological evidence of gestalt perception of a human dyad: extended discussion and theoretical viewpoint

Karima Mersad, Philippe Oliviero

In this commentary, we provide further discussion and interpretation of a recent article entitled “Blending into the Crowd: Electrophysiological Evidence of Gestalt Perception of a Human Dyad”, published one year ago by the first author of the present commentary. Firstly, drawing a parallel between the experiment described in the above article and another closely comparable experimental study, we propose that the neural integration process evidenced when seeing two human shapes close in space is a marker of the categorization of a stimulus as a group of humans (two here) represented as an entity per se.

Review Article Open Access

Human and Earth evolution through CO2: Perspective for climate crisis

Kenji Sorimachi

Although human civilization has developed through genomic evolution, including its fingernail-functional cooperation, the daily lives of humans have resulted in a significant amount of carbon dioxide (CO₂) being released into the atmosphere since the Industrial Revolution, which started almost 200 years ago. Recently, climate change has been documented to have spread globally.

Commentary Open Access

Could in vivo histological and gene expression analysis of aged skin be useful for pointing new paths for cosmetics development?

Bagatin E, Martin RP, Varela P, Gomes CP, Marins MM, Filippeli-Silva R, Yarak S, Soares JLM, Pesquero JB

Skin aging is related to intrinsic or chronological and extrinsic or environmental factors. Oxidative stress, with generation of Reactive Oxygen Species (ROS), occurs during oxidative cell metabolism, mostly on mitochondria, and it is aggravated by chronic exposition to Ultra-Violet (UV)B (short wavelength) and UVA (long wavelength) sun radiations.

Mini Review Open Access

Prognostic impact of mildly decreased renal function after multivessel coronary revascularization: A mini-review

Tae Oh Kim, Duk-Woo Park

Cardiovascular disease is a major cause of morbidity and mortality in patients with chronic kidney disease (CKD). Such cardiovascular risk is not limited to those with advanced renal disease, as even patients with early stages of renal dysfunction show increased risk of cardiovascular morbidity and mortality.

Mini Review Open Access

Utilizing wheat arabinoxylans as a potent functional biomaterial for fabrication of hydrogels: A mini review

Qiaomei Zhu, Ping Wang, Min Zhang

Arabinoxylans (AXs) are the major structural cell wall component of various cereal brans. As an important dietary fiber source, AXs contain ferulic acids, proteins and other functional ester compounds. These functional components offer AXs well-established health benefits, such as prebiotic effect, antioxidant property, antitumor activity and immunomodulatory property.

Short Communication Open Access

Wide-field photoacoustic imaging in a snap with a single-element detector

Lei S. Li

Photoacoustic imaging has increasing biomedical applications, from fundamental research to clinical translations, due to its high optical absorption contrast and high acoustic resolution in deep tissue. The current implementations of photoacoustic imaging employ either a multi-element ultrasonic array for parallel signal detection or raster-scanning of a single-element detector for serial data acquisition, demanding a trade-off between throughput and cost.

Research Article Open Access

Racial underrepresentation in dermatological datasets leads to biased machine learning models and inequitable healthcare

Giona Kleinberg, Michael J Diaz, Sai Batchu, Brandon Lucke-Wold

Modern advances in artificial intelligence are phenomenal as trained machine learning models are learning to solve humanities greatest problems. In addition to the many technical problems machine learning models are attempting to solve, there is a plethora of research on the possible clinical applications of machine learning.