Loading
Journal of Biomed Research
ISSN: 2693-5910
Volume 4, Issue 1, p1-71
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Digital workflow for high-risk, low-volume procedure simulation
For thousands of years, simulations have been used by doctors for training before performing high-risk procedures on patients. Due to changes in healthcare and academic environments, as well as the introduction of new technologies, we have seen an increase in the use of simulation for education and competency assessment.
J Biomed Res, 2023, Volume 4, Issue 1, p1-7 | DOI: 10.46439/biomedres.4.27
A brief review of industrial fluorosis in domesticated bovines in India: Focus on its socio-economic impacts on livestock farmers
An excessive and repeated high fluoride exposure over a long period of time is harmful to the health of humans and domestic animals and causes several toxic effects in the form of fluorosis disease. If fluoride exposure is due to industrial fluoride, the disease is known as industrial fluorosis. In recent years, due to rapid industrialization in India, various health problems are increasing continuously among domesticated bovine animals, cattle (Bos taurus) feed and water buffalo (Bubalus bubalis) living and grazing in industrial areas due to industrial fluoride pollution.
J Biomed Res, 2023, Volume 4, Issue 1, p8-15 | DOI: 10.46439/biomedres.4.028
The high-performance youth soccer players carbohydrate ingestion does not seem to change between base categories
Youth soccer players undergo a maturational changes which result in physiological, anatomical, and biological changes during adolescence. During seven years of follow-up, it was observed that in youth soccer, the sprint distance and number of sprints increased by ~35%, whereas the number of high-intensity actions increased by ~50%.
J Biomed Res, 2023, Volume 4, Issue 1, p16-17 | DOI: 10.46439/biomedres.4.029
COVID-19 vaccination, disease severity and practice when COVID turns from endemic to epidemic disease
The most significant global public health issue is still COVID-19. Due to the advent of a new variation and the widespread use of COVID-19 immunization, the disease is currently not as severe as it was in 2020. The immunization is still required, though. Here, the authors examine and offer suggestions for COVID-19 immunization as the illness transitions from an epidemic to an endemic condition.
J Biomed Res, 2023, Volume 4, Issue 1, p18-19 | DOI: 10.46439/biomedres.4.030
On a match day, what should an elite soccer players routine look like?
Many questions arise from what may or may not be applicable for an elite soccer player to do during the competitive match day. Currently, we know that athletes are concentrated in hotels and there they receive all the food for the day, i.e., the match day diet. Besides that, the supplementation is usually offered at the stadium.
J Biomed Res, 2023, Volume 4, Issue 1, p20-21 | DOI: 10.46439/biomedres.4.031
Recent advances in pediatric telemedicine
Telemedicine is a medical service, which is offered across a spatial distance. Doctors and patients use digital tools such as apps, teleconsultation platforms or video technology. There is currently no uniform and generally applicable definition of telemedicine. In the broadest sense it is understood to mean the overcoming of temporal and spatial distances in the context of medical issues.
J Biomed Res, 2023, Volume 4, Issue 1, p22-24 | DOI: 10.46439/biomedres.4.032
Comparative study on chitin content of Bangladeshi edible and medicinal mushrooms
Chitin provides immense beneficial roles to the humanity and environment. Most of the chitin extracted worldwide are from the shell of the crustaceans. An alternative source of chitin has been observed as the number of crustaceans has been dilapidating. Here, extraction of chitin from the edible and medicinal macrofungi, mushrooms, have been described.
J Biomed Res, 2023, Volume 4, Issue 1, p25-28 | DOI: 10.46439/biomedres.4.033
Chronic fluoride poisoning in domestic equines, horses (Equus caballus) and donkeys (Equus asinus)
Repeated chronic fluoride (F) exposure for prolonged duration through water, air, and food causes F poisoning in the form of fluorosis in both humans and domestic and wild animals. However, among domestic equine animals, horses (Equus caballus) and donkeys (Equus asinus), chronic F poisoning caused by industrial fluoride pollution and fluoridated drinking water has been well studied.
J Biomed Res, 2023, Volume 4, Issue 1, p29-32 | DOI: 10.46439/biomedres.4.034
Experimental autoimmune encephalomyelitis of mice: Catalytic cross site-specific hydrolysis of H1 histone by IgG antibodies against H1, H2A, H2B, H3, H4 histones, and myelin basic protein
Histones and their different modified forms are extremely important in chromatin functioning. Free extracellular histone molecules, however, usually act as damage factors. Treatment of experimental mice with exogenous histones results in systemic toxic responses because of inflammatory reactions and activation of Toll-like receptors
J Biomed Res, 2023, Volume 4, Issue 1, p33-60 | DOI: 10.46439/biomedres.4.035
Pulmonary agenesis in a newborn
There are all transitions from hypoplasia of the lung to agenesis or aplasia of a lung lobe and to complete absence of the entire lung system as classifies such malformations as follows: a) unilateral complete absence of lung and bronchus, b) absence of one half of the lung and a short blind course of the associated bronchus, c) trunk bronchus formed, lung as a hazelnut- to fist-sized, unflap fist- sized, unlobed, fleshy structure in the mediastinum.
J Biomed Res, 2023, Volume 4, Issue 1, p61-63 | DOI: 10.46439/biomedres.4.036
Is drinking groundwater in India safe for human health in terms of fluoride?
Groundwater has been an invaluable resource for humanity for centuries. India is the world’s largest user of groundwater. It is mostly used not only for drinking and cooking but also for miscellaneous domestic purposes and irrigation in agriculture. Hand-pumps, bore-wells, step-wells, and open deep dug-wells continue to be the primary and major sources of groundwater production in India.
J Biomed Res, 2023, Volume 4, Issue 1, p64-71 | DOI: 10.46439/biomedres.4.037
Lung ultrasound: a new standard for diagnosis of ventilator associated pneumonia?
As the soft tissue- air interface is virtually impenetrable to ultrasound, its utility for evaluating lung pathologies was historically thought to be unfeasible [1]. However, the observation of different artifacts and novel research into their interpretations has helped transform this dogma and develop lung ultrasound as a valuable diagnostic tool in pulmonary diseases.
Dietary practice among mainstream bengali population and ethnic communities in bangladesh
Bangladesh has a number of ethnic minor group population and they lead their life in great ethnic diverse fashion [1]. They constitute about 1% of total population [1]. They are distributed in scattered way all over the hilly, riverine and dense forest region of the country [1].
Glucan and Vitamin D supplementation showed synergy in improvements of the immune response against an influenza challenge in mice
Influenza infection remains a serious health problem throughout the world. Unfortunately, current medicine offers no real treatment or protection, moving our attention to alternative options. In this study we aimed to evaluate the possible effects of a combination of glucan and vitamin C on immunosuppression caused by influenza infection.
Management of traumatic fracture-dislocation of the shoulder in children: A systematic review of published case reports
Proximal humerus fracture with simultaneous shoulder dislocation in children is a rare occurrence, with few reported cases. This systematic review of case reports aimed to document the outcomes of different treatment methods. A comprehensive literature search from 1980 to 2024 included case reports on traumatic shoulder fracture-dislocation in children. Eighteen studies were included, with a mean followup of 1.5 years. The cases comprised 7 boys and 11 girls, aged between 11 months and 16 years (median 6 years). The cases were divided into two groups based on epiphysealinvolvement.
AI-driven designed protein epigenomics
The biological revolutions of computationally designed proteins, induced pluripotent stem cells (iPSCs), and the CRISPR-Cas9 system finally enables modifications that can spur deep understanding of spatial requirement of epigenetic information. This commentary describes the utility of a computationally designed protein, EED Binder (EB), when fused to dCas9 (EBdCas9) for identifying critical sites of PRC2 dependent histone H3K27me3 marks in the chromatin.
The physiology of seminal plasma proteins in the equine female reproductive tract
Functional proteomics of seminal plasma has been reviewed by Samanta and co-workers, highlighting greater biologic relevancy and diverse functions of this seminal component to reproductive biology than previously thought. Although not requested for successful fertilization, important biological functions are associated with seminal plasma and the authors suggested that selected proteins may serve as diagnostic biomarkers for various conditions.
COVID-19 and burnout of physicians redeployed to emergency care
The COVID-19 pandemic of 2020-2023 significantly affected emergency medical care. Physicians who regularly saw their patients by appointment were redeployed to emergency care, increasing their reported burnout. Understanding how the burnout of specialists increased from this redeployment during COVID-19 is relevant to finding ways to reduce redeployment burnout in these appointment-based physicians when preparing for future pandemics.
Association between the prevalence of obstructive lung disease and the use of aspirin in a diabetic population
Aspirin (acetylsalicylic acid), a non-steroidal anti-inflammatory drug, inhibits cyclooxygenases (COX-1 and COX-2), which catalyze the conversion of arachidonic acid to prostaglandins. In control environments, low-dose aspirin (75 mg or 81 mg) inhibits COX-1 and disrupts the production of thromboxane, reducing platelet aggregation
Drosophila male germline stem cells and their transit amplifying daughters depend on G-protein signaling for increasing their mitotic indices in response to mating
In many metazoan tissues, highly specialized cells are constantly lost and need to be replaced by tissue homeostasis from adult stem cells. When adult stem cells divide by mitosis their daughter cells either become new stem cells, or enter a proliferation and differentiation path. Recent studies in Drosophila males showed that germline stem cells (GSCs) can increase their mitotic activity in response to repeated mating.
High exposure to pollution requires nutritional improvements in children
Sickness rates of children living in regions with extreme environmental pollution resulted in our study evaluating effects of 30-day supplementation with two different food supplements containing nucleotides, amino acids and polypeptides or β-glucan. This study was based on published studies evaluating these effects on children with chronic respiratory problems transported to the region without environmental pollution and into the medical program complemented with climatotherapy, speleotherapy, higher motion activity, rehabilitation, and a special nutritional program.
Potential enhanced association between obstructive lung disease and history of depression in patients with diabetes
Depression is one of the most common comorbidities of chronic diseases including diabetes and obstructive lung diseases (emphysema, chronic bronchitis, and asthma). Obstructive lung diseases and depression have few symptoms in common. However, they are both common in adults and associated with chronic inflammation. It is not clear if their coappearance in diabetic patients is coincidental or associated beyond that expected by chance.
Craniovertebral junction abnormalities in children: Surgical, anesthetic and intensive care implications
The craniovertebral junction is unique and the most complex of the axial skeleton in multiple aspects; embryology, anatomy, pathology and kinematics. A surgical physiological approach to management of its abnormalities was instituted at the University of Iowa Hospitals & Clinics (UIHC) in 1977 and has been the accepted treatment algorithm worldwide.
Further comments on the single-cell protein ingredient manufactured from a non-GMO Corynebacterium glutamicum as an alternative protein nutrition
In the previous study, Park et al. reported the efficacy of a single-cell protein manufactured from a growth-accelerated high-vital Corynebacterium glutamicum strain and potential strain selection strategy for development of non-GMO industrial strains harboring enriched target nutritional component, named as growth?acceleration?targeted evolution (G.A.T.E.) strategy [1].
Robotic-assisted bronchoscopy for peripheral pulmonary lesions: A single-center experience of the Ion platform
The diagnostic yield of electromagnetic navigational bronchoscopy to access lung lesions remains low. The multicenter NAVIGATE study showed the diagnostic yield to be 71% for lesions up to 3 cm and 67% for lesions up to 2 cm. The introduction of robotic-assisted navigational platforms may overcome some of the traditional barriers encountered with previous approaches.
Deregulation of Slug/Snail2 and TGF-β crosstalk in airway epithelial stem/progenitor cells: A key link between COPD and lung cancer?
This commentary focuses on two recent publications showing deregulation of the transcription factor Slug/Snail2 and TGF-β function in primary bronchial basal/progenitor cells of patients with Chronic Obstructive Pulmonary Disease (COPD) and the impact on proliferation and the expression of genes involved in stem cell maintenance. We discuss the molecular mechanisms related to the exhaustion of airway basal stem/progenitor cells in tobacco smoke-induced COPD, as well as putative links between COPD and lung cancer at the molecular level.
iBALT and nodular lymphoid hyperplasia in TNF-overexpressing mice
In response to any danger signal, cytokines are promptly secreted to help fight back the attackers. Tumour necrosis factor (TNF) is one of the most potent inflammatory cytokines and its expression is tightly regulated to prevent uncontrolled inflammation. We have shown that three regulatory elements located in Tnf 3’untranslated region (3’UTR) cooperate post-transcriptionally to maintain low levels of Tnf expression during homeostasis.
Recent advances on visual cycle protein research and progress on clinical translation
Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP.
COVID-19 and the Liver: Uncovering the Hidden Culprit behind Liver Injury
The effects of COVID-19 have been of increasing interest in all fields of medicine after the pandemic, especially considering the important impact and incidence of patients infected with coronavirus. Numerous studies have reported the vast clinical implications related to permanent organ and tissue damage after infection and long COVID.
Bioengineering Providing Tailor-Made Products
Bioengineering is a new discipline of science that apply engineering principles and techniques on the biological process for development of valuable bioactive molecule, designing metabolites and changing cells or cellular metabolites to combat the current as well as future challenges and problem of mankind. This is one of the most challenging fields testing the researcher’s intelligence, dedication, skill and creativity and courage needed to contradict convention and cut new pathways through unexplored scientific terrain.
Epidemiology of United States ocular injuries at home in preschool age children from 2000-2019
Injuries to the eye are a common cause of emergency department (ED) visits in the pediatric age group. There were nearly 14 million ED visits for traumatic injuries in children under age 5 in 2017 in the US, and most of these occurred at a private residence [1]. The highest number of pediatric ED visits for ocular injury were reported in children ages 1-5.