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Journal of Biomed Research
ISSN: 2693-5910
Volume 5, Issue 1, p1-135
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Knowledge of nutrition in sports science students of Chittagong University
The study of nutrition dates back to over 200 years; however, sports nutrition is a relatively new discipline involving the application of nutritional principles to enhance athletic performance. Nutrition affects a sportsman in many ways. At the basic level, it plays an important role in achieving and maintaining health.
J Biomed Res, 2024, Volume 5, Issue 1 | DOI: 10.46439/biomedres.5.039
Evidence-based educational algorithm “Anki” for optimization of medical education
Anki is an open-sourced educational platform that utilizes a spaced repetition-based algorithm for information retention. This application has become increasingly popular among medical students and residents over recent years. The aim of this review was to describe this novel education technique, provide reasons for its adoption, and summarize the available literature regarding the efficacy of this method.
J Biomed Res, 2024, Volume 5, Issue 1, p1-7 | DOI: 10.46439/biomedres.5.037
Gender difference in nutritional knowledge, dietary pattern, and nutritional status of undergraduates in Tartous University, Syria
The adolescent and young adulthood frames of life offer a crucial window of opportunity for health promotion and disease prevention. At this stage, individuals are free from the influence of parents and take personal decisions on food choices and other lifestyle habits.
J Biomed Res, 2024, Volume 5, Issue 1, p8-16 | DOI: 10.46439/biomedres.5.038
Insights into the chemical composition, nutritional value, and pharmacological activities of Nelumbo nucifera Gaertn
Nelumbo nucifera Gaertn (NNG), commonly known as lotus, holds significant importance in traditional medicine due to its diverse pharmacological activities. This appraisal provides an updated overview of the chemical composition, nutritional value, and pharmacological activities of Nelumbo nucifera Gaertn in the context of metabolic diseases.
J Biomed Res, 2024, Volume 5, Issue 1, p26-28 | DOI: 10.46439/biomedres.5.040
Recent developments in the diagnosis, treatment, and management of cardiovascular diseases through artificial intelligence and other innovative approaches
Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide, and early diagnosis, treatment, and management are essential for reducing the burden of these diseases. This systematic review provides an update on recent developments in the field of CVDs, including the use of artificial intelligence (AI) in diagnosis and management, advances in genetic testing and precision medicine, the role of telemedicine and remote monitoring technologies, novel therapies such as gene therapy and cell therapy, and the importance of addressing mental health in the prevention and management of CVDs.
J Biomed Res, 2024, Volume 5, Issue 1, p29-40 | DOI: 10.46439/biomedres.5.041
Transforming glomerulonephritis care through emerging diagnostics and therapeutics
Glomerulonephritis refers to inflammation and injury of the glomeruli, the tiny filtration units within the kidneys. It can arise from various causes like infections, autoimmunity, and genetic factors, and may be acute or chronic. Symptoms include blood and protein in the urine, high blood pressure, and swelling, though manifestations differ.
J Biomed Res, 2024, Volume 5, Issue 1, p41-52 | DOI: 10.46439/biomedres.5.043
Tailoring interactions for cisPro peptide bond stabilization
Elucidation of the nature of non-covalent interactions that govern the rate-limiting cis-trans isomerism at Xaa-Pro peptide bonds is fundamental to unravelling the protein folding mechanism, the stereoelectronic control elements of the structure and dynamics of the peptide bond, and the design of novel peptide isosteres.
J Biomed Res, 2024, Volume 5, Issue 1, p53-61 | DOI: 10.46439/biomedres.5.044
The halftime strategies applied to elite soccer players for rehydration and maintain performance
The professionals involved soccer should understand that due to the game’s rules there may not be possibility correct hydration for soccer players during the matches and the opportunities that may appear to drink electrolytic drinks are still limited, not only drinks, but also opportunities to offer carbohydrates in gel form during matches.
J Biomed Res, 2024, Volume 5, Issue 1, p62-64 | DOI: 10.46439/biomedres.5.045
Effect of sawdust and rice straw on yield and yield attributes of different strains of Pleurotus cystidiosus
To evaluate the effect of sawdust (SD) and rice straw (RS) on yield of different strains of Pleurotus cystidiosus (PCYS1-5), various yield attributes were measured in the present experiment. Among them, the best effect had been observed in the case of PCYS2. The highest mycelial running rate was observed in PCYS-2 + SD (0.84 cm). The highest average number of fruiting body/packet was observed in the treatment PCYS-2 +SD (61.00), followed by PCYS-1 +SD (58.00), PCYS-2 +RS (58.00) and the lowest in the treatment PCYS-3 +RS (47.00).
J Biomed Res, 2024, Volume 5, Issue 1, p65-70 | DOI: 10.46439/biomedres.5.046
Experimental autoimmune encephalomyelitis of mice: Enzymatic cross site-specific hydrolysis of H3 histone by IgGs against H3, H1, H2A, H2B, and H4 histones, and myelin basic protein
Histones, with their various modified forms, are vitally important in chromatin functioning. However, free extracellular histone molecules in biological liquids usually act as damage factors. Mice treatment with exogenous histones determines several toxic responses because of inflammatory reactions and activation of Toll-like receptors.
J Biomed Res, 2024, Volume 5, Issue 1, p71-95 | DOI: 10.46439/biomedres.5.047
Modeling of psychological time cognition with Human Language based Consciousness model
This paper interprets subjective psychological time in a model of consciousness called the HLbC model proposed by the authors. Time has an objective physical time and a subjective psychological time. Subjective psychological time is thought to vary in its flow depending on the individual and the situation. For this explanation, this paper introduces surreal numbers into the perception of subjective psychological time.
J Biomed Res, 2024, Volume 5, Issue 1, p96-102 | DOI: 10.46439/biomedres.5.048
Dietary habit, hygiene practice, and disease status among street children: A cross sectional survey
Child rag pickers in Dhaka city are increasing and very little known about their conditions and nutritional status. They lead a very vulnerable life and high risk of prone to different kinds of diseases. An observational cross-sectional study was carried out at selected areas of Dhaka to assess food habit, hygiene practice and disease pattern of street children.
J Biomed Res, 2024, Volume 5, Issue 1, p103-107 | DOI: 10.46439/biomedres.5.049
CRISPR-Cas systems: A revolution in genome editing and its diverse applications
The clustered regularly interspaced short palindromic repeats (CRISPR) Cas (CRISPR6 associated protein) system is an advanced adaptive immune system found in prokaryotes. First discovered in1987, CRISPR Cas has revolutionized genetic research in the past two decades. CRISPR-Cas9 the most widespread system enables precise gene editing by creating double strand breaks.
J Biomed Res, 2024, Volume 5, Issue 1, p108-114 | DOI: 10.46439/biomedres.5.050
Recent advances and challenges in brain tumor segmentation utilizing α-expansion graph cut
This commentary summarizes our team's recent study, "Brain Tumor Segmentation Based on α-Expansion Graph Cut," by discussing the recent advances in deep learning integration, multimodality imaging, and real-time segmentation tools. It also highlights the strengths of the method in energy minimization and noise handling done throughout the study, while it addresses the challenges related to scalability, deep learning integration, and generalization.
J Biomed Res, 2024, Volume 5, Issue 1, p115-118 | DOI: 10.46439/biomedres.5.051
Total lymphocyte count and wound dehiscence of patients with oral squamous cell carcinoma
Nutritional status is a sensitive indicator of health. There is not a single parameter that serve as the only and best parameter to evaluate malnourished patients or patients with risk for malnutrition. Patients with oral squamous cell carcinoma were a focus of concern for nutritional impairment. Nutritional impairment is a common phenomenon among the patients with oral squamous cell carcinoma.
J Biomed Res, 2024, Volume 5, Issue 1, p119-122 | DOI: 10.46439/biomedres.5.052
Determination of allelic, phenotypic, and genotypic frequency of the distribution of ABO and Rh blood groups among Injibara University students, Ethiopia
Blood is the body's main fluid, transporting nutrition, oxygen, and hormones throughout the entire structure. Rh antigen and blood types are inherited. The first chromosome contains the Rh antigen gene, while the ninth chromosome has the ABO antigen gene.
J Biomed Res, 2024, Volume 5, Issue 1, p123-129 | DOI: 10.46439/biomedres.5.053
From decay to decadence: Fungal alchemy in waste valorization
Fungal alchemy harnesses fungi's enzymatic efficiency to naturally degrade synthetic plastics. Enzymes like cutinase and lipase, secreted by Aspergillus and Penicillium, break down plastics, while lignocellulolytic enzymes and oxidant ions aid in this process. Aspergillus nidulans, Bjerkandera adusta, and Pleurotus ostreatus drive bioenergy and genetic engineering innovations for a sustainable eco-friendly approach to plastic waste management and waste valorization.
J Biomed Res, 2024, Volume 5, Issue 1, p130-135 | DOI: 10.46439/biomedres.5.054
Glucan and Vitamin D supplementation showed synergy in improvements of the immune response against an influenza challenge in mice
Influenza infection remains a serious health problem throughout the world. Unfortunately, current medicine offers no real treatment or protection, moving our attention to alternative options. In this study we aimed to evaluate the possible effects of a combination of glucan and vitamin C on immunosuppression caused by influenza infection.
Detection of some synthetic cannabinoids (FUB-AMB and AB-FUBINACA) in blood and urine using Gas Chromatography-mass spectrometry liquid–liquid extraction
In recent years, various types of synthetic cannabinoids have become widely distributed and are causing social and health problems in most parts of the world. Synthetic cannabinoids are currently the largest group of new psychoactive substances. Those that have been subjected to legal control are replaced by newer controlled and uncontrolled substances.
Food-to-mealtime associations influence food selection in a UK-based sample
Humans tend to consume food throughout the day in a regular pattern [1]. This routinised behaviour reflects primal foraging strategies of repeating tried and tested fruitful paths to obtain food, without predation or starvation [2]. Modern-day food-related routines are still unpinned by these ancestral behaviours but are shaped by social, environmental and culture factors that influence preferences and beliefs about food [3,4].
How to improve the regenerative potential of mesenchymal stem cells (MSCs) for the use in regenerative medicine?
Mesenchymal stem cells (MSCs) are widely used in regenerative medicine. They can be isolated from different adult tissues. However, the regenerative potential of MSCs obtained from various sources and from different age donors may significantly differ.
Role of the rapid delayed rectifier K+ current in human induced pluripotent stem cells derived cardiomyocytes
The action potential (AP) in cardiac tissue is important for initiating and coordinating contractions in the heart. In addition, the long refractory period minimizes the potential for developing extrasystoles and arrhythmias. The AP is generated by coordinate changes in different ionic currents. In human (or canine) adult ventricular cells, the depolarization phase of the AP is mainly through the influx of Na+ and Ca2+ through specific voltage gated channels.
Commentary on “Discussing diabetes, palliative care and end of life care: choosing the right language”
Our paper entitled “Discussing diabetes, palliative care and end of life care: choosing the right language” reports a core aspect of our research program, which focuses on older people with diabetes, palliative and end of life care for people with diabetes, and the effect of language on clear communication, that commenced in 2009 [1].
Current understanding of gender dimorphism regarding type 2 diabetes
Today, both type 1 and type 2 diabetes mellitus affect 33.3 million people in the United States and nearly 500 million adults worldwide, and there is concern that this number may increase steadily in the future. Previous studies have linked the development of type 2 diabetes to multiple lifestyle factors, including physical activity level and diet, and biological characteristics, such as body composition, age, and race; however, current research suggests that gender may also have an impact on one’s risk of developing type 2 diabetes. Variations in type 2 diabetes diagnosis, prevalence, and progression have been found between males and females.
Drosophila male germline stem cells and their transit amplifying daughters depend on G-protein signaling for increasing their mitotic indices in response to mating
In many metazoan tissues, highly specialized cells are constantly lost and need to be replaced by tissue homeostasis from adult stem cells. When adult stem cells divide by mitosis their daughter cells either become new stem cells, or enter a proliferation and differentiation path. Recent studies in Drosophila males showed that germline stem cells (GSCs) can increase their mitotic activity in response to repeated mating.
High exposure to pollution requires nutritional improvements in children
Sickness rates of children living in regions with extreme environmental pollution resulted in our study evaluating effects of 30-day supplementation with two different food supplements containing nucleotides, amino acids and polypeptides or β-glucan. This study was based on published studies evaluating these effects on children with chronic respiratory problems transported to the region without environmental pollution and into the medical program complemented with climatotherapy, speleotherapy, higher motion activity, rehabilitation, and a special nutritional program.
Potential enhanced association between obstructive lung disease and history of depression in patients with diabetes
Depression is one of the most common comorbidities of chronic diseases including diabetes and obstructive lung diseases (emphysema, chronic bronchitis, and asthma). Obstructive lung diseases and depression have few symptoms in common. However, they are both common in adults and associated with chronic inflammation. It is not clear if their coappearance in diabetic patients is coincidental or associated beyond that expected by chance.
Further comments on the single-cell protein ingredient manufactured from a non-GMO Corynebacterium glutamicum as an alternative protein nutrition
In the previous study, Park et al. reported the efficacy of a single-cell protein manufactured from a growth-accelerated high-vital Corynebacterium glutamicum strain and potential strain selection strategy for development of non-GMO industrial strains harboring enriched target nutritional component, named as growth?acceleration?targeted evolution (G.A.T.E.) strategy [1].
Adiponectin receptor fragmentation in mouse models of type 1 and type 2 diabetes
The protein hormone adiponectin regulates glucose and fatty acid metabolism by binding to two PAQR-family receptors (AdipoR1 and AdipoR2). Both receptors feature a C-terminal segment which is released by proteolysis to form a freely circulating C-terminal fragment (CTF) found in the plasma of normal individuals but not in some undefined diabetes patients.
Research update on the state of the evidence for stem cell and regenerative medicine in cerebral palsy
Stem cell therapy for the treatment of cerebral palsy is a rapidly expanding area of research that has been identified as a high priority by consumers. There are several types and sources of stem cell therapies under investigation. Stem cell treatments proposed for cerebral palsy are believed to provide benefit via some or all of the following mechanisms including immunomodulation, paracrine signaling and supporting endogenous reparative processes.
Deregulation of Slug/Snail2 and TGF-β crosstalk in airway epithelial stem/progenitor cells: A key link between COPD and lung cancer?
This commentary focuses on two recent publications showing deregulation of the transcription factor Slug/Snail2 and TGF-β function in primary bronchial basal/progenitor cells of patients with Chronic Obstructive Pulmonary Disease (COPD) and the impact on proliferation and the expression of genes involved in stem cell maintenance. We discuss the molecular mechanisms related to the exhaustion of airway basal stem/progenitor cells in tobacco smoke-induced COPD, as well as putative links between COPD and lung cancer at the molecular level.
Cxcl17 and its association with T cells
We recently published an article describing the importance of CXCL17 in T cell responses [1]. In summary, we observed the following:
1) Cxcl17 is necessary to maintain normal ratios of T cell subpopulations in lymph nodes (LN).
2) Cxcl17-/- mice develop more intense inflammatory responses than wild type mice.
Observations on nascent matrix structures in embryonic cornea: Important in cell interactions, or merely vestiges of the lens surface?
Here we present some new observations on early stages in chick corneal development obtained by re-mining of datasets obtained via serial block face scanning electron microscopy. We focus on matrix cords, proteoglycan-rich structures of apparent ectodermal origin, emerging from the epithelial basal lamina, which extend proximally into the growing collagenous matrix destined to become the corneal stroma.
iBALT and nodular lymphoid hyperplasia in TNF-overexpressing mice
In response to any danger signal, cytokines are promptly secreted to help fight back the attackers. Tumour necrosis factor (TNF) is one of the most potent inflammatory cytokines and its expression is tightly regulated to prevent uncontrolled inflammation. We have shown that three regulatory elements located in Tnf 3’untranslated region (3’UTR) cooperate post-transcriptionally to maintain low levels of Tnf expression during homeostasis.
Mesenchymal Stem Cells and PRP combined therapy promotes gastric leak closure following sleeve gastrectomy
Sleeve gastrectomy is the most common bariatric surgery worldwide. However, such a surgery caries risk of complications associated with morbidity and mortality. Gastric leak can occur and represents one of the most severe complications following sleeve gastrectomy. Since the two last decades, regenerative medicine has emerged, offering new strategies to face to sleeve gastrectomy complications.
Post-allogeneic stem cell transplant FLT3-targeted maintenance therapy: updates and considerations for clinical practice
Acute myeloid leukemia (AML) is characterized by multiple molecular and cytogenetic abnormalities, with increasing data to support clinical and prognostic implications to guide clinical decision making. One of the most well described mutations involves fms-like tyrosine kinase 3 (FLT3) that results in a constitutively active tyrosine kinase and is generally associated with poor prognosis involving shorter overall survival and higher rates of relapse.
Can regulatory-driven process innovation open the door for cellular therapies in emerging markets?
Due to their impressive clinical success, CAR-T therapies are becoming a more mainstream treatment for patients with hematologic malignancies. In order to make this promising form of therapy accessible to patients in need worldwide, a robust scale-up of such a complex supply chain, that is also affordable worldwide, is essential. Already a challenging endeavor in most privileged countries, but a chimerical undertaking in the more logistically challenged regions and emerging markets across the globe.