Journal of Cancer Biology

The incorporation of patient-reported outcomes (PROs) is essential for assessing whether a cancer treatment enhances overall patient well-being, beyond merely extending survival. This scoping review aimed to identify and analyze the use of PROs in ovarian cancer clinical trials.

Acute myeloid leukemia (AML) is characterized by multiple molecular and cytogenetic abnormalities, with increasing data to support clinical and prognostic implications to guide clinical decision making. One of the most well described mutations involves fms-like tyrosine kinase 3 (FLT3) that results in a constitutively active tyrosine kinase and is generally associated with poor prognosis involving shorter overall survival and higher rates of relapse.

Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP.

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairments that might be accompanied by declines in activities of daily living, neuropsychiatric disorders and a loss of motor function [1,2]. At present, the prevalence of dementia of Alzheimer’s type (DAT) is approximately 4% among elderly people [3]. With the increase in the aging the population, the number of individuals with DAT is still increasing.

Pediatric Functional Gastrointestinal Disorders (p-FGID) comprise one of the most common chronic conditions impacting global health. Conceptualized as gut-brain communication disorders, p-FGID are often exacerbated by and contribute to significant anxiety as well as functional impairment. Cognitive behavioral therapy is the gold standard psychosocial treatment for anxiety spectrum disorders. 

In animal cells (especially humans), there is an enzyme called acid sphingomyelinase (ASM) (EC 3.1.4.12) which can break the large molecule of sphingomyelin and convert it into smaller structures of ceramide and phosphorylcholine.

Since Gershon and Kondo’s initial description of suppressor T cells as antigen-specific T cells that regulate immune responses [1], several advances have taken place on the biology and potential applications of regulatory T cells (Tregs) in clinical settings. After that, Sakaguchi et al.

This study presents a comprehensive exploration into the shared molecular mechanisms linking psoriasis and major depressive disorder (MDD), two conditions that are increasingly recognized as having potential comorbidities. It offers new insights into the immune and genetic pathways that may contribute to both disorders, emphasizing the potential of CD19 as a biomarker and therapeutic target through the PPARγ/β-catenin/Wnt3a signaling pathway.

Stroke is the most common cause of disability and the number two cause of death worldwide. The TOAST classification denotes five subtypes of ischemic stroke, large-artery atherosclerosis, cardioembolism, small-vessel occlusion, stroke of other determined etiology and stroke of undetermined etiology.

Epigenetics is the study of heritable modifications to gene expression, such as DNA methylation, histone modifications, and RNA modifications, that do not alter the nucleotide sequence of the corresponding gene. Recently, RNA modification has emerged as a novel research focus. 

In prior work, we analyzed gene expression profiles of mouse, rat and human gastrocnemius muscles to identify conserved regulators of muscle aging processes. By further comparing data obtained from different muscles we found stronger conservation of aging-related factors at the level of molecular pathways than at the level of individual genes.

The skeletal system consists mostly of extracellular matrix and mineral salts. Osteoblasts and chondrocytes create enormous amounts of extracellular matrix proteins for skeletal systems to grow and sustain. Many skeletal metabolism related proteins are produced by endoplasmic reticulum (ER) and secrete outside cell membrane then form to extracellular oligometric matrix proteins and collagens. 

A two herbs formula has been successfully used as a cardiovascular supplement (tonic) to maintain a healthy vascular endothelial state in four groups of patients presenting with different symptom manifestations: coronary obstruction; hypertension; menopausal cardiovascular instability; and peripheral arterial disease. 

Plasma cell myeloma is a hematopoietic neoplasm with morphologic and genetic heterogeneity. Genetics have been shown to play an important role in risk stratification of plasma cell myeloma however the correlation between genetic aberrations and morphologic features is not well studied. In performing a systematic study of 266 multiple myeloma bone marrow biopsies from 329 patients, we initially investigated the association between bone marrow morphology, conventional cytogenetics, gene expression profiling and gene mutations

Machine learning (ML) is a branch of artificial intelligence that uses an algorithm to process the data, retrieve valuable information, learn from it, find a pattern, and make predictions. Manual data analyses suffer from several disadvantages including it is time-consuming and subject to error.

Rheumatoid arthritis (RA) is a chronic, autoimmune disease that is associated with local and systemic inflammation, resulting in chronic pain and physical function limitations that may negatively impact quality of life (QOL). Despite advances in pharmacological therapies, currently available treatment options may be associated with adverse events and come at a high price tag.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that is associated with local and systemic inflammation, resulting in chronic pain and physical function limitations that may negatively impact quality of life (QOL). Despite advances in pharmacological therapies, currently available treatment options may be associated with adverse events and come at a high price tag.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that is associated with local and systemic inflammation, resulting in chronic pain and physical function limitations that may negatively impact quality of life (QOL). Despite advances in pharmacological therapies, currently available treatment options may be associated with adverse events and come at a high price tag.

The epidermal growth factor receptor (EGFR) is a member of the ErbB family. It is involved in biological processes such as cell proliferation, angiogenesis, inhibition of apoptosis, adhesion, metastasis, and is associated with the progression of lung cancer [1-3].

Rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis are common rheumatic diseases leading to irreversible joint damage and increase in mortality. The introduction of highly effective biologic drugs has resulted in substantial benefit in the treatment of these diseases, but these therapies take a high toll on healthcare systems.