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Journal of Allergy and Infectious Diseases
ISSN: 2692-6334
Volume 1, Issue 1, p1-20
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Targeting Caspase-4 and pyroptosis as a new therapeutic approach for asthma
Asthma is a chronic inflammatory disease of the lung caused by a combination of environmental and genetic factors. Although symptoms of mild asthma are treated with current medications, such as bronchodilators and steroids, severe asthma remains very difficult to manage. Asthma rates are constantly on the rise and there is a clear need for novel asthma therapies especially in severe asthma.
J Allergy Infect Dis, 2020, Volume 1, Issue 1, p1-4 | DOI: 10.46439/allergy.1.001
Dynamics of the coronavirus pandemic in Italy and some global predictions
The pandemic caused by coronavirus COVID-19 are of great concern. A detailed scientific analysis of this phenomenon is still to come, but now it is urgently needed to evaluate the parameters of the disease dynamics in order to make some preliminary estimations of the number of cases and possible duration of the pandemic. The corresponding mathematical models must be simple enough, since their parameters are unknown and have to be estimated using limited statistical data sets.
J Allergy Infect Dis, 2020, Volume 1, Issue 1, p5-8 | DOI: 10.46439/allergy.1.002
Influenza infection and aortic dissection: A commentary on the association between a viral syndrome and major cardiac events in the context of the current COVID-19 pandemic
Acute type A aortic dissection (ATAAD) is the leading cause of morbidity and mortality for patients with thoracic aortic aneurysms, despite significant advances in the surgical treatment. An aortic dissection is a life-threatening condition which occurs when blood enters through a tear in the wall of the aorta causing the aortic layers to separate or “dissect”.
J Allergy Infect Dis, 2020, Volume 1, Issue 1, p9-14 | DOI: 10.46439/allergy.1.003
Linear IgA bullous dermatosis in patients with inflammatory bowel disease should not be mistaken for drug allergy
A 36-year-old Hispanic male, with a history of ulcerative colitis (UC) presented to the inflammatory bowel disease (IBD) clinic for initial evaluation. Over the past six years, the patient had been treated for his UC with various therapies including prednisone, multiple mesalamine formulations, and budesonide but always discontinued therapy due to what he perceived were adverse drug reactions. He described onset of pruritic blisters, affecting his chest, abdomen, back, and arms.
J Allergy Infect Dis, 2020, Volume 1, Issue 1, p15-17 | DOI: 10.46439/allergy.1.004
Multisystem inflammatory syndrome in children (MIS-C): The role of viral superantigens in COVID-19 disease
Superantigens are viral or bacterial virus proteins that can specifically activate a large ratio of T cells. In contrast to classic peptide antigen recognition, superantigens do not require processing in small peptides, but act as fully or partially processed proteins. They can bind to class II molecules of the main histocompatibility complex and stimulate T cells that express certain beta chains of the T cell recipient V.
J Allergy Infect Dis, 2020, Volume 1, Issue 1, p18-20 | DOI: 10.46439/allergy.1.005
COVID-19 and burnout of physicians redeployed to emergency care
The COVID-19 pandemic of 2020-2023 significantly affected emergency medical care. Physicians who regularly saw their patients by appointment were redeployed to emergency care, increasing their reported burnout. Understanding how the burnout of specialists increased from this redeployment during COVID-19 is relevant to finding ways to reduce redeployment burnout in these appointment-based physicians when preparing for future pandemics.
Planned procedures and covid-19 pandemic: Does recovery plan, a matter of urgency?
The COVID-19 pandemic brought many challenges to each sector of life. The most affected are the health in general and elective services in specific. The postponement of planned surgical procedures is one of the elective services that not only increased the waiting time in the short-term but will strain the healthcare services in the long-run
The emergence of new coronaviruses: A critical evaluation of factors, implications, and mitigation strategies
The emergence of new coronaviruses poses a significant global health threat, as witnessed during recent outbreaks. Coronaviruses were first identified in the 1960s, primarily causing mild respiratory illnesses in humans. The introduction of the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002, on the other hand, constituted a watershed moment. The outbreak began in China and swiftly spread to numerous nations, resulting in severe respiratory sickness and a global public health disaster. The SARS-CoV outbreak demonstrated coronaviruses' ability to cause severe illness and inspired substantial study into their origins and transmission patterns.
Healthcare professionals’ awareness and knowledge of COVID-19 and radiation safety
Background: lack of knowledge and awareness of COVID-19 and radiation safety among healthcare professionals will adversely affect their health and the patients’ safety due to unnecessary radiation exposure and rapid spread of COVID-19. The purpose of this study is to evaluate the knowledge and the awareness of both domains; COVID-19 and radiation awareness in one survey study.
Anesthetic considerations for previously COVID-19 positive patients: design and rapid implementation of a perioperative surgical home (PSH) program
The COVID-19 pandemic presents unprecedented challenges for anesthesia professionals and their surgical patients. Beyond managing infection risk, positive COVID-19 surgical patients add additional challenges to their perioperative care, where its perioperative risk are superimposed onto an already baseline anesthesia risk in real-time with an unknown and unpredictable fashion.
COVID-19 and the Liver: Uncovering the Hidden Culprit behind Liver Injury
The effects of COVID-19 have been of increasing interest in all fields of medicine after the pandemic, especially considering the important impact and incidence of patients infected with coronavirus. Numerous studies have reported the vast clinical implications related to permanent organ and tissue damage after infection and long COVID.
Auditory system and COVID-19
The COVID-19 pandemic that emerged in 2020 may affect the peripheral and central auditory system. According to studies in the literature, symptoms affecting the vestibulocochlear system such as sudden hearing loss, tinnitus, and vestibular neuritis are seen in individuals with COVID -19.
A case of trigeminal neuralgia after COVID-19
The trigeminal nerve is one of twelve pairs of cranial nerves that attach to the brain. The name “trigeminal” literally means three twins and refers to the fact that the fifth cranial nerve has three major divisions: the ophthalmic (V1), the maxillary (V2), and the mandibular (V3) [1]. The trigeminal nerve is the major sensory nerve of the face and is the nerve of the first branchial arch.
Physiotherapy in Mental Health Facing the Covid-19 Pandemic
According to the International Organization of Physical Therapy in Mental Health (IOPTMH), physiotherapy in mental health is a recognized specialty of physical therapy, with a subgroup representing physiotherapists from around the world before the World Confederation of Physical Therapy (WCPT). It is implemented in different settings, in health, psychiatry and psychosomatic medicine.
Association of COVID-19 coronavirus and Kawasaki syndrome like features in 1-5 years old children
In the nightmare of the coronavirus pandemic that is spreading around the world, parents could take comfort in one thing - early reports that the virus mysteriously spares children, even though this often leads to critical illness in older people. An article published in the Journal “Pediatrics”, based on 2,143 young people in China, provides the most comprehensive evidence of the spread of the virus among children, and there is bad news and good news [1].
A commentary on telehealth and telemedicine in the COVID-19 era: A world of opportunities for the neurosurgeon
The COVID-19 pandemic has produced unprecedented conditions and difficulties for the global delivery of healthcare services. In this situation, all the healthcare employees, including neurosurgeons are facing many complexities. Telemedicine has decreased the spread of infection between neurosurgeons and patients.
Mass food challenges in a vacant COVID-19 step-down facility: reflections on the management of anaphylaxis
A popular western misconception dating back to at least the time of President John F Kennedy is that one of the Chinese characters in the word “crisis” means opportunity. The manuscript
“Management of anaphylaxis in children undergoing oral food challenges in an adapted COVID-19 field hospital” [1] detailed a highly successful attempt to not only mitigate the effects of the crisis for
elective care brought by the COVID-19 pandemic but to seek to maximize the opportunity by better utilization and redeployment of staff allowing the team to reduce pre-pandemic waiting lists by 57%.
An overview of clinical, molecular, and therapeutic approaches to Niemann-Pick disease
In animal cells (especially humans), there is an enzyme called acid sphingomyelinase (ASM) (EC 3.1.4.12) which can break the large molecule of sphingomyelin and convert it into smaller structures of ceramide and phosphorylcholine.
Vaccination, politics and COVID-19 impacts: update
In an earlier manuscript, the author found a strong relationship between political views, vaccination levels and COVID-19 death rates. This study revealed that in U.S. counties where large proportions of voters cast their ballot for Donald Trump in the 2020 presidential election, vaccination levels were lower and COVID-19 death rates were higher. This update explores this relationship six months later when more recent data are available. The updated analysis found that with the passage of time, the relationship between political views, vaccination levels and COVID-19 death rates became even stronger.
Spinal cord infarction associated with severe acute respiratory syndrome coronavirus 2: A case series of diagnostic challenges and postacute sequelae of COVID-19
Spinal cord infarction is extremely uncommon among vascular events, accounting for only 0.3-1% of all strokes and 5-8% of acute myelopathies. While deep vein thrombosis, pulmonary embolism, and stroke are commonly observed complications of COVID-19, spinal cord infarction is relatively rare.
Exploring Immune Cell Profiles and NLRP3 Gene Expression as Potential Diagnostic Markers in COVID-19 Patients: A Commentary
The COVID-19 pandemic caused by the SARS-CoV-2 virus continues to impact populations worldwide, emphasizing the need for improved diagnostic and treatment strategies. Understanding the immune response and identifying early diagnostic markers are crucial in this endeavor. In this comprehensive commentary, we delve into a recent study that investigated the immune cell profiles and NLRP3 gene expression as potential diagnostic markers in COVID-19 patients.
Short comment on COVID-19 pandemic in Mongolia
Mongolia is located between Russia to the north and China to the south, where it neighbors the Inner Mongolia Autonomous Region. The total population in Mongolia is about 3.3 million and nearly half of the people live in the capital, Ulaanbaatar, and in other provincial centers.
COVID-19 vaccine hesitancy in nursing: Home staff and the need for ongoing education and vaccine access
Objective: To study vaccine hesitancy among health care workers who provide direct care in nursing homes and long-term care facilities which cater to the most vulnerable population of the community.
Cancer-related anxiety, COVID-19, and the oncologist: the formation of a ‘Balint’ process group
The management of anxiety and distress in patients with cancer is stressful for the oncology clinicians who treat them. Unfortunately, psychosocial care for patients with cancer is not universally available or standardized. Referrals from oncology services to psychological serves are often not initiated early enough, may not be encouraged from medicine or surgical services, and are subsequently foregone or patients do not follow up beyond a single appointment.
Technology-based mental health treatment and the impact on the therapeutic alliance update and commentary: How COVID-19 changed how we think about telemental health
Our previous article, Technology-Based Mental Health Treatment and the Impact on the Therapeutic Alliance, explored factors that influence the therapeutic alliance when treatment was delivered via telemental health, such as video conferencing or telephone. During the COVID-19 pandemic, the use of telemental health became a necessity rather than simply a preference. In this commentary, we explore the use of telemental health in direct response to COVID-19 social distancing orders and offer updated suggestions around best practices for building and maintaining alliance in technology-based mental health treatments.