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Journal of Allergy and Infectious Diseases
ISSN: 2692-6334
Volume 2, Issue 1, p1-32
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Feeding cats egg product with Polyclonal-Anti-Fel d1 antibodies decreases environmental Fel d1 and allergic response: A proof of concept study
Background: Cat allergens are a major contributor to environmental allergens' overall burden, but efforts to reduce cat allergens are often unsuccessful.
Objective: To determine whether feeding cats a diet containing an egg product with anti-Fel d1 IgY would produce clinically relevant reductions in allergy symptoms of human subjects.
Intranasal therapy and COVID-19: A comprehensive literature review
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is highly virulent and can be transmitted via respiratory droplets and close contact. Recent studies suggest that although viral load could be a poor predictor of disease, the concentration of the virus in the respiratory tract may be linked to contagiousness when coupled with significant co-variables factors such as nasal discharge and cough, hence impacting transmission.
J Allergy Infect Dis, 2021, Volume 2, Issue 1, p9-16 | DOI: 10.46439/allergy.2.016
Modulation of type 2 inflammation by sensing immunomodulatory RNA in house dust mite and viruses
The incidence of allergic diseases has been increasing over the past few decades worldwide. Although allergic reactions are often characterized by an overzealous Th2 inflammatory response, the underlying mechanisms remain poorly defined. House dust mite (HDM) is one of the most common indoor allergens that cause allergic diseases such as asthma.
J Allergy Infect Dis, 2021, Volume 2, Issue 1, p17-23 | DOI: 10.46439/allergy.2.017
Severe SARS-CoV-2 infection treated with the mannose binding lectin associated serine protease 2 (MASP2) inhibitor Narsoplimab
In SARS-CoV-2 infection, increased inflammation, complement activation, and excessive clotting are responsible for morbidity and mortality. Recent reports suggest that mannose binding lectin (MBL) and mannose-associated serine protease 2 (MASP2) lies at the intersection of these pathways. Consistent with this concept, we observed that the SARS-CoV-2 spike protein binds MBL-MASP1/2 complex in human serum. We therefore suggested treating a severely ill, ventilated SARS-CoV-2 patient in whom all other treatments had failed with the anti-MASP2 antibody Narsoplimab. Following a 4-week course of Narsoplimab, the patient made a near complete recovery, supporting the utility of MASP2 inhibition for treating hospitalized SARS-CoV-2 patients.
J Allergy Infect Dis, 2021, Volume 2, Issue 1, p24-28 | DOI: 10.46439/allergy.2.018
Monitoring clinical trials in infectious diseases
In early 2020, the contagious and deadly virus, SARS-CoV-2, was identified. The virus spread rapidly worldwide and was declared a pandemic by the World Health Organization (WHO) in March of 2020 [1]. While many who became infected remained asymptomatic, an alarming number of infected individuals developed severe symptoms, often requiring hospitalization and intensive care, or resulting in death.
J Allergy Infect Dis, 2021, Volume 2, Issue 1, p29-32 | DOI: 10.46439/allergy.2.019
Surgical smoke and SARS-CoV-2 transmission
The protection of health care workers from nosocomial infection is a paramount consideration in the current pandemic involving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Not only is prevention of viral transmission the most effective means to lessen the public health impact of coronavirus disease 2019 (COVID-19), but also both quarantine and illness – that disproportionately affect health care workers – have devastating effects on the ability of hospitals to adequately care for increased patient loads.
COVID-19 and burnout of physicians redeployed to emergency care
The COVID-19 pandemic of 2020-2023 significantly affected emergency medical care. Physicians who regularly saw their patients by appointment were redeployed to emergency care, increasing their reported burnout. Understanding how the burnout of specialists increased from this redeployment during COVID-19 is relevant to finding ways to reduce redeployment burnout in these appointment-based physicians when preparing for future pandemics.
Planned procedures and covid-19 pandemic: Does recovery plan, a matter of urgency?
The COVID-19 pandemic brought many challenges to each sector of life. The most affected are the health in general and elective services in specific. The postponement of planned surgical procedures is one of the elective services that not only increased the waiting time in the short-term but will strain the healthcare services in the long-run
The emergence of new coronaviruses: A critical evaluation of factors, implications, and mitigation strategies
The emergence of new coronaviruses poses a significant global health threat, as witnessed during recent outbreaks. Coronaviruses were first identified in the 1960s, primarily causing mild respiratory illnesses in humans. The introduction of the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002, on the other hand, constituted a watershed moment. The outbreak began in China and swiftly spread to numerous nations, resulting in severe respiratory sickness and a global public health disaster. The SARS-CoV outbreak demonstrated coronaviruses' ability to cause severe illness and inspired substantial study into their origins and transmission patterns.
Healthcare professionals’ awareness and knowledge of COVID-19 and radiation safety
Background: lack of knowledge and awareness of COVID-19 and radiation safety among healthcare professionals will adversely affect their health and the patients’ safety due to unnecessary radiation exposure and rapid spread of COVID-19. The purpose of this study is to evaluate the knowledge and the awareness of both domains; COVID-19 and radiation awareness in one survey study.
mTOR: A possible therapeutic target against SARS-CoV-2 infection
The recent pandemic of SARS-CoV-2 has emerged as a health emergency to develop effective therapeutic strategies for restricting deadly disease, COVID-19. SARS-CoV-2 infects cells by the endocytosis process via receptor-mediated binding and priming by cellular proteases.
Anesthetic considerations for previously COVID-19 positive patients: design and rapid implementation of a perioperative surgical home (PSH) program
The COVID-19 pandemic presents unprecedented challenges for anesthesia professionals and their surgical patients. Beyond managing infection risk, positive COVID-19 surgical patients add additional challenges to their perioperative care, where its perioperative risk are superimposed onto an already baseline anesthesia risk in real-time with an unknown and unpredictable fashion.
Theory on the involvement of retroviruses and EBV in autoimmunity
There is a striking likeness between an old model for the action of mobile genetic elements in Maize and recent observations on endogenous retroviruses in human Multiple Sclerosis. Nexø discussed this and other developments in his recent theory on autoimmunity. Specifically, in analogy to the onc genes Nexø suggest that insertion of a retrovirus activates a so-called aut gene. This aut gene may well be an EBV genome.
COVID-19 and the Liver: Uncovering the Hidden Culprit behind Liver Injury
The effects of COVID-19 have been of increasing interest in all fields of medicine after the pandemic, especially considering the important impact and incidence of patients infected with coronavirus. Numerous studies have reported the vast clinical implications related to permanent organ and tissue damage after infection and long COVID.
Auditory system and COVID-19
The COVID-19 pandemic that emerged in 2020 may affect the peripheral and central auditory system. According to studies in the literature, symptoms affecting the vestibulocochlear system such as sudden hearing loss, tinnitus, and vestibular neuritis are seen in individuals with COVID -19.
A case of trigeminal neuralgia after COVID-19
The trigeminal nerve is one of twelve pairs of cranial nerves that attach to the brain. The name “trigeminal” literally means three twins and refers to the fact that the fifth cranial nerve has three major divisions: the ophthalmic (V1), the maxillary (V2), and the mandibular (V3) [1]. The trigeminal nerve is the major sensory nerve of the face and is the nerve of the first branchial arch.
Physiotherapy in Mental Health Facing the Covid-19 Pandemic
According to the International Organization of Physical Therapy in Mental Health (IOPTMH), physiotherapy in mental health is a recognized specialty of physical therapy, with a subgroup representing physiotherapists from around the world before the World Confederation of Physical Therapy (WCPT). It is implemented in different settings, in health, psychiatry and psychosomatic medicine.
Association of COVID-19 coronavirus and Kawasaki syndrome like features in 1-5 years old children
In the nightmare of the coronavirus pandemic that is spreading around the world, parents could take comfort in one thing - early reports that the virus mysteriously spares children, even though this often leads to critical illness in older people. An article published in the Journal “Pediatrics”, based on 2,143 young people in China, provides the most comprehensive evidence of the spread of the virus among children, and there is bad news and good news [1].
A commentary on telehealth and telemedicine in the COVID-19 era: A world of opportunities for the neurosurgeon
The COVID-19 pandemic has produced unprecedented conditions and difficulties for the global delivery of healthcare services. In this situation, all the healthcare employees, including neurosurgeons are facing many complexities. Telemedicine has decreased the spread of infection between neurosurgeons and patients.
Is vitamin D the missing link between childhood obesity and adenovirus-36 infection?
It may seem irony that nutrition science historically pertained mostly to undernutrition and deficiency syndromes [1] but nowadays prevention, control and treatment of overnutrition, manifested as overweight and obesity, has become the main task of most nutritionists and related professionals [2].
Mass food challenges in a vacant COVID-19 step-down facility: reflections on the management of anaphylaxis
A popular western misconception dating back to at least the time of President John F Kennedy is that one of the Chinese characters in the word “crisis” means opportunity. The manuscript
“Management of anaphylaxis in children undergoing oral food challenges in an adapted COVID-19 field hospital” [1] detailed a highly successful attempt to not only mitigate the effects of the crisis for
elective care brought by the COVID-19 pandemic but to seek to maximize the opportunity by better utilization and redeployment of staff allowing the team to reduce pre-pandemic waiting lists by 57%.
Antenatal SARS-COV-2 exposure leading to multisystem inflammatory syndrome (MIS-N) presenting with neonatal encephalopathy
A 22-day-old male neonate was admitted to the neonatal intensive care unit (NICU) with complaints of abnormal movements, fever, breath holding spells, refusal and bluish discoloration of skin. He was born at term with a birthweight of 2·72 kg to a mother with a history of positive polymerase chain reaction for SARS-Coronavirus-2 (SARS-COV-2) virus (RT-PCR-positive), asymptomatic 2019 novel coronavirus disease (COVID-19) at 32-33 weeks gestation, which did not require any supportive measures.
Vaccination, politics and COVID-19 impacts: update
In an earlier manuscript, the author found a strong relationship between political views, vaccination levels and COVID-19 death rates. This study revealed that in U.S. counties where large proportions of voters cast their ballot for Donald Trump in the 2020 presidential election, vaccination levels were lower and COVID-19 death rates were higher. This update explores this relationship six months later when more recent data are available. The updated analysis found that with the passage of time, the relationship between political views, vaccination levels and COVID-19 death rates became even stronger.
Congenital Cytomegalovirus screening in newborns: Current status in the United States
Congenital Cytomegalovirus (cCMV) infection is the leading cause of non-hereditary sensorineural hearing loss (SNHL) and developmental delay in children with an approximate prevalence rate of 0.7% [1].
Spinal cord infarction associated with severe acute respiratory syndrome coronavirus 2: A case series of diagnostic challenges and postacute sequelae of COVID-19
Spinal cord infarction is extremely uncommon among vascular events, accounting for only 0.3-1% of all strokes and 5-8% of acute myelopathies. While deep vein thrombosis, pulmonary embolism, and stroke are commonly observed complications of COVID-19, spinal cord infarction is relatively rare.