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Journal of Allergy and Infectious Diseases
ISSN: 2692-6334
Volume 2, Issue 3, p52-83
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Nonstructural proteins of SARS-CoV-2
COVID-19 is a serious global health threat caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus enters human host cells through the recognition of angiotensin converting enzyme 2 (ACE2) receptors or cluster of differentiation 147 (CD147) via the virus’s spike glycoprotein. Once inside the cell, SARS-CoV-2 uses its genomic RNA as template to produce the two overlapping polyproteins, pp1a and pp1ab, that are subsequently cleaved into 16 nonstructural proteins (NSPs).
J Allergy Infect Dis, 2021, Volume 2, Issue 3, p52-65 | DOI: 10.46439/allergy.2.025
Impact of COVID-19 vaccination drive in adults on vaccine-induced immunity in India: A Markov cohort model
Objective: Need to control the COVID-19 pandemic resurgence is a priority in India which has an estimated population of 1.39199 billion. Immunity whether acquired by recovery or vaccine, controls an infectious disease epidemic. In case of COIVD-19, the latter is more desirable. The objective of this study is to answer a research question “What is the impact of current vaccination drive in adults in generating vaccine-induced immunity in India?”
J Allergy Infect Dis, 2021, Volume 2, Issue 3, p66-72 | DOI: 10.46439/allergy.2.026
Multiplexing with a new dimension for serological analysis of infectious diseases
In April 2021, researchers from the University of Rochester reported on the methods used to convert multiplex SARS-CoV-2 IgG serology and neutralization assays into novel dual reporter IgG and IgM assays on the Luminex® xMAP® INTELLIFLEX DR-SE (RUO) System. The multiplex SARS-CoV-2 IgG detection assay was developed by Cameron et al. on the Luminex FLEXMAP 3D® System for detecting IgG antibodies against the spike (S), receptor-binding domain (RBD), and nucleocapsid (Nc) antigens of SARS-CoV-2.
J Allergy Infect Dis, 2021, Volume 2, Issue 3, p73-74 | DOI: 10.46439/allergy.2.027
Possible therapeutic targets for SARS-CoV-2 infection and COVID-19
SARS-CoV-2 infection causes COVID-19, which has emerged as a health emergency worldwide. SARS-CoV-2 infects cells by binding to ACE2 receptors and enters into the cytoplasm following its escape from endolysosomes. Once in the cytoplasm, the virus replicates and eventually causes various pathological conditions including acute respiratory distress syndrome (ARDS) that is caused by pro-inflammatory cytokine storms.
J Allergy Infect Dis, 2021, Volume 2, Issue 3, p75-83 | DOI: 10.46439/allergy.2.028
Surgical smoke and SARS-CoV-2 transmission
The protection of health care workers from nosocomial infection is a paramount consideration in the current pandemic involving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Not only is prevention of viral transmission the most effective means to lessen the public health impact of coronavirus disease 2019 (COVID-19), but also both quarantine and illness – that disproportionately affect health care workers – have devastating effects on the ability of hospitals to adequately care for increased patient loads.
COVID-19 and burnout of physicians redeployed to emergency care
The COVID-19 pandemic of 2020-2023 significantly affected emergency medical care. Physicians who regularly saw their patients by appointment were redeployed to emergency care, increasing their reported burnout. Understanding how the burnout of specialists increased from this redeployment during COVID-19 is relevant to finding ways to reduce redeployment burnout in these appointment-based physicians when preparing for future pandemics.
Planned procedures and covid-19 pandemic: Does recovery plan, a matter of urgency?
The COVID-19 pandemic brought many challenges to each sector of life. The most affected are the health in general and elective services in specific. The postponement of planned surgical procedures is one of the elective services that not only increased the waiting time in the short-term but will strain the healthcare services in the long-run
Healthcare professionals’ awareness and knowledge of COVID-19 and radiation safety
Background: lack of knowledge and awareness of COVID-19 and radiation safety among healthcare professionals will adversely affect their health and the patients’ safety due to unnecessary radiation exposure and rapid spread of COVID-19. The purpose of this study is to evaluate the knowledge and the awareness of both domains; COVID-19 and radiation awareness in one survey study.
mTOR: A possible therapeutic target against SARS-CoV-2 infection
The recent pandemic of SARS-CoV-2 has emerged as a health emergency to develop effective therapeutic strategies for restricting deadly disease, COVID-19. SARS-CoV-2 infects cells by the endocytosis process via receptor-mediated binding and priming by cellular proteases.
Anesthetic considerations for previously COVID-19 positive patients: design and rapid implementation of a perioperative surgical home (PSH) program
The COVID-19 pandemic presents unprecedented challenges for anesthesia professionals and their surgical patients. Beyond managing infection risk, positive COVID-19 surgical patients add additional challenges to their perioperative care, where its perioperative risk are superimposed onto an already baseline anesthesia risk in real-time with an unknown and unpredictable fashion.
Commentary on ‘Late presentation of right coronary artery stent infection as left empyema and pleuro-pericardial fistula’
The case study describes a rare and maybe fatal consequence of coronary stent infection (CSI), with an emphasis on the rise in occurrence over the last decade [1]. In order to enhance patient outcomes, the authors stress the need for early recognition and proper medical and surgical management. Coronary artery disease (CAD) is a serious global health concern, with an estimated 126 million people worldwide suffering from it. In addition, CAD caused millions of fatalities in 2017 [2].
Rheumatic fever: A classical model of a postinfection autoimmune disease and vaccine perspectives
Streptococcus pyogenes infection continues to be a worldwide public health problem causing various diseases in humans, including impetigo and oropharyngeal infections that are responsible for the development of rheumatic fever (RF), a multi-organ inflammatory disorder, Rheumatic heart disease (RHD) is its major sequel that leads to heart valves lesions, clinically classified as regurgitation and/or stenosis.
COVID-19 and the Liver: Uncovering the Hidden Culprit behind Liver Injury
The effects of COVID-19 have been of increasing interest in all fields of medicine after the pandemic, especially considering the important impact and incidence of patients infected with coronavirus. Numerous studies have reported the vast clinical implications related to permanent organ and tissue damage after infection and long COVID.
Auditory system and COVID-19
The COVID-19 pandemic that emerged in 2020 may affect the peripheral and central auditory system. According to studies in the literature, symptoms affecting the vestibulocochlear system such as sudden hearing loss, tinnitus, and vestibular neuritis are seen in individuals with COVID -19.
A case of trigeminal neuralgia after COVID-19
The trigeminal nerve is one of twelve pairs of cranial nerves that attach to the brain. The name “trigeminal” literally means three twins and refers to the fact that the fifth cranial nerve has three major divisions: the ophthalmic (V1), the maxillary (V2), and the mandibular (V3) [1]. The trigeminal nerve is the major sensory nerve of the face and is the nerve of the first branchial arch.
Physiotherapy in Mental Health Facing the Covid-19 Pandemic
According to the International Organization of Physical Therapy in Mental Health (IOPTMH), physiotherapy in mental health is a recognized specialty of physical therapy, with a subgroup representing physiotherapists from around the world before the World Confederation of Physical Therapy (WCPT). It is implemented in different settings, in health, psychiatry and psychosomatic medicine.
Association of COVID-19 coronavirus and Kawasaki syndrome like features in 1-5 years old children
In the nightmare of the coronavirus pandemic that is spreading around the world, parents could take comfort in one thing - early reports that the virus mysteriously spares children, even though this often leads to critical illness in older people. An article published in the Journal “Pediatrics”, based on 2,143 young people in China, provides the most comprehensive evidence of the spread of the virus among children, and there is bad news and good news [1].
A commentary on telehealth and telemedicine in the COVID-19 era: A world of opportunities for the neurosurgeon
The COVID-19 pandemic has produced unprecedented conditions and difficulties for the global delivery of healthcare services. In this situation, all the healthcare employees, including neurosurgeons are facing many complexities. Telemedicine has decreased the spread of infection between neurosurgeons and patients.
Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome and tetralogy of fallot; Case report and literature review
WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome is a rare primary immunodeficiency disorder characterized by susceptibility to human papillomavirus (HPV) infections, neutropenia, and hypogammaglobulinemia.
Is vitamin D the missing link between childhood obesity and adenovirus-36 infection?
It may seem irony that nutrition science historically pertained mostly to undernutrition and deficiency syndromes [1] but nowadays prevention, control and treatment of overnutrition, manifested as overweight and obesity, has become the main task of most nutritionists and related professionals [2].
Mass food challenges in a vacant COVID-19 step-down facility: reflections on the management of anaphylaxis
A popular western misconception dating back to at least the time of President John F Kennedy is that one of the Chinese characters in the word “crisis” means opportunity. The manuscript
“Management of anaphylaxis in children undergoing oral food challenges in an adapted COVID-19 field hospital” [1] detailed a highly successful attempt to not only mitigate the effects of the crisis for
elective care brought by the COVID-19 pandemic but to seek to maximize the opportunity by better utilization and redeployment of staff allowing the team to reduce pre-pandemic waiting lists by 57%.
Antenatal SARS-COV-2 exposure leading to multisystem inflammatory syndrome (MIS-N) presenting with neonatal encephalopathy
A 22-day-old male neonate was admitted to the neonatal intensive care unit (NICU) with complaints of abnormal movements, fever, breath holding spells, refusal and bluish discoloration of skin. He was born at term with a birthweight of 2·72 kg to a mother with a history of positive polymerase chain reaction for SARS-Coronavirus-2 (SARS-COV-2) virus (RT-PCR-positive), asymptomatic 2019 novel coronavirus disease (COVID-19) at 32-33 weeks gestation, which did not require any supportive measures.
Vaccination, politics and COVID-19 impacts: update
In an earlier manuscript, the author found a strong relationship between political views, vaccination levels and COVID-19 death rates. This study revealed that in U.S. counties where large proportions of voters cast their ballot for Donald Trump in the 2020 presidential election, vaccination levels were lower and COVID-19 death rates were higher. This update explores this relationship six months later when more recent data are available. The updated analysis found that with the passage of time, the relationship between political views, vaccination levels and COVID-19 death rates became even stronger.
Investigation of urinary β2 microglobulin; substitute for interferon-γ as a suppressor of pulmonary fibrosis in a preterm with chronic lung disease following intrauterine infection
In the respiratory management of preterm infants of less than 33 weeks gestational age and very low birth weight infants, it is essential to understand changes in chest X-ray and blood gas findings in addition to observing their clinical symptoms.