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Journal of Allergy and Infectious Diseases
ISSN: 2692-6334
Volume 6, Issue 1, p1-41
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
A real life asthma biologic treatment comparison
Currently, it is estimated that only a small percentage of asthmatic patients do not achieve adequate control of the disease despite maintaining high doses of inhaled corticosteroids and assuming that they have a correct adherence and inhalation technique. In fact, severe asthma currently accounts for 5-10% of all asthma cases and is often driven by type 2 inflammatory mediators.
J Allergy Infect Dis, 2025, Volume 6, Issue 1, p1-7 | DOI: 10.46439/allergy.6.048
The effect of an aerosol of treignac mineral water concentrated by inverse osmosis in vitro on normal bronchial cells and in vivo on normal rabbit lungs
Hydrotherapy is a common technique used in thermal centers, primarily for the external treatment of skin pathologies. Various centers specializing in the management of infectious and inflammatory respiratory pathologies use hydrotherapy techniques internally, as well as through nasally, and bronchially
J Allergy Infect Dis, 2025, Volume 6, Issue 1, p8-12 | DOI: 10.46439/allergy.6.049
Innate lymphoid cell development
Innate lymphoid cells (ILCs) are a heterogeneous family of lymphocytes that lack conventional antigen receptors and play roles in tissue homeostasis and immune responses. Based on their transcriptional and functional properties, ILCs are classified into three main groups: group 1 ILCs (ILC1s and NK cells), group 2 ILCs (ILC2s), and group 3 ILCs (ILC3s). The developmental origins of ILCs remain an area of active investigation.
J Allergy Infect Dis, 2025, Volume 6, Issue 1, p13-16 | DOI: 10.46439/allergy.6.050
Impact of SARS-CoV-2 vaccinations on pandemic dynamics: Trends in cases, deaths, and fatality risks
Despite the decrease in COVID-19 testing and reporting new infections, the numbers of new cases and deaths per capita registered in some European countries and USA in September 2024 were higher than endemic limits and exceeded seasonal flu mortality. These facts make the development of new vaccines or the further use of existing ones very urgent.
J Allergy Infect Dis, 2025, Volume 6, Issue 1, p17-24 | DOI: 10.46439/allergy.6.051
Exploring the relationship between sex and long COVID
In December 2019, an outbreak of pneumonia, of unknown cause and often-fatal evolution, emerged among people linked to a seafood and live animal market in the city of Wuhan, China. Days later, health authorities in that country reported that the epidemic outbreak in that location was caused by a coronavirus, later named SARS CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2).
J Allergy Infect Dis, 2025, Volume 6, Issue 1, p25-27 | DOI: 10.46439/allergy.6.052
Our clinical experience in Van Province of Turkey; The relationship between Fasciola hepatica and eosinophil count
Fasciola hepatica is a liver trematode with worldwide animal distribution, most commonly seen in sheep- and cattle-raising areas. The flukes are leak-like, flat worms, measuring 2–4 cm. The number of reports of Fasciola hepatica has increased significantly recently, and several geographical areas have been described as endemic for the disease in humans, with prevalence and incidence ranging from low to very high.
J Allergy Infect Dis, 2025, Volume 6, Issue 1, p28-35 | DOI: 10.46439/allergy.6.053
Knowledge, perceptions, and practices related to soil transmitted helminth infections among family doctors in the municipality of San Miguel Del Padrón, Havana. Results of an intervention to improve expertise
Almost all programs for the control of soil-transmitted helminth infections implemented across Asia, Africa, and Latin America have focused on at-risk population through mass deworming, health education, and, when possible, environmental sanitation, underestimating the importance of the physician's role in these populations. The physician who provides services in the communities is an opinion leader, and if equipped with the necessary cognitive tools, could be crucial in any attempt to control many entities, including soil-transmitted helminth infections.
J Allergy Infect Dis, 2025, Volume 6, Issue 1, p36-41
Neodymium:YAG laser posterior capsulotomy in the lateral decubitus position
Here we report a novel method of performing a Neodyminium:YAG (Nd:YAG) laser posterior capsulotomy in an adult patient, unable to tolerate the procedure awake with topical anaesthesia in the outpatient clinic setting. The procedure was performed by altering the chin rest and arms of the Nd:YAG laser machine so that the procedure could be undertaken in an anaesthetized patient in the operating theatre, in the lateral decubitus position, with the laser machine upright in its normal position.
Presbyopia correcting IOLs and the ocular surface disease… The good, the bad and the ugly
The last two decades were especially fruitful for the refractive surgeons and for the industry who have been showing tremendous development in both understanding and meeting patients’ desire for spectacle independence. Ever since the first trials from Dr. Kenneth Hoffer with his early 1980’s effort in producing a multifocal IOL to the latest achievements from different companies in putting trifocals and EDOF optics to the market.
How many mutations does it take to make a uveal melanoma?
Uveal melanoma (UM) is a rare cancer that affects the choroid and, less frequently, the ciliary body or the iris (for recent reviews see [1-3]). Despite a profound knowledge of the oncogenic mechanisms behind UM tumorigenesis and despite an accurate cytogenetic and molecular prognosis, only limited advances have been made in UM therapy.
MSICS is a Simple Solution for a Big Problem
Manual small-incision cataract surgery (MSICS) is a sutureless cataract surgery that has multiple advantages over traditional phacoemulsification and extracapsular cataract extraction (ECCE) procedures. SICS became the procedure of choice for international ophthalmology, where the microscopes and operating room can be more challenging, in addition to the more advanced pathology often seen.
Surgical smoke and SARS-CoV-2 transmission
The protection of health care workers from nosocomial infection is a paramount consideration in the current pandemic involving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Not only is prevention of viral transmission the most effective means to lessen the public health impact of coronavirus disease 2019 (COVID-19), but also both quarantine and illness – that disproportionately affect health care workers – have devastating effects on the ability of hospitals to adequately care for increased patient loads.
Association between resilience promotion factors during childhood and risk of drug use disorder during adulthood
Few studies have been conducted on the relationship between “outside-residing” resilience characteristics and the risk of developing drug use disorder later in life. These characteristics include responsive and caring parenting, household routines involving regular family meals and bedtime routines, social support from peers, participation in organized activities, and religious service attendance.
New Frontiers in the Rehabilitation of Neurological Damage
Epidemiologic data show a high incidence of central nervous system (CNS) disease, which therefore is a prominent healthcare issue. Adults and the elderly are most commonly affected, with heavy repercussions on society and caregivers. The outcome of CNS disease, whether the etiology is vascular, degenerative or traumatic, is often significant disability or death. Motor, language and cognitive deficits are most prevalent, but vision is also frequently affected, in the form of visual field defects or oculomotor and binocular disorders. In the present paper, we discuss peripheral and central visual field defects.
Fibromyalgia, perfectionism, and interpersonal style. Further evidence for a person-centered approach
Fibromyalgia (FM) is usually considered a ‘medically unexplained’ chronic pain disorder with no known causal treatment. The disorder is also referred to as a ‘functional somatic syndrome’ in which psychological factors are believed to play an important role. According to recent criteria of the American College of Rheumatology (ACR), the main symptom is unexplained widespread pain for at least 3 months; associated symptoms include fatigue, impaired concentration, non-restorative sleep, stimulus intolerance, post-exertional malaise, and various complaints related to neuro-vegetative dysfunction.
The effect of preoperative in-person education on the pain severity of patients undergoing coronary artery bypass graft (CABG) surgery
Pain is one of the most common symptoms experienced by patients undergoing coronary artery bypass graft (CABG) surgery. Adequate pain management is critical to the well-being and overall recovery of these patients. This study aimed to evaluate the effect of preoperative in-person pain education on the pain severity experienced by patients undergoing CABG surgery in Rajaie Cardiovascular, Medical and Research Center in Tehran in 2022. In this quasi-experimental study, 72 patients undergoing coronary artery bypass surgery were selected and randomly divided into intervention (n=36) and control (n=36) groups.
Understanding microbial influence on mental health
The past decade in science has seen an influx of new research articles showing the relationship between the human gut microbiome and its direct or indirect effect on the Central Nervous System (CNS). Much of the current research points to microbial therapy as a potential treatment option for many mental health disorders and conditions.
Lung ultrasound: a new standard for diagnosis of ventilator associated pneumonia?
As the soft tissue- air interface is virtually impenetrable to ultrasound, its utility for evaluating lung pathologies was historically thought to be unfeasible [1]. However, the observation of different artifacts and novel research into their interpretations has helped transform this dogma and develop lung ultrasound as a valuable diagnostic tool in pulmonary diseases.
Focused ultrasound: Innovation in use for neurologic conditions
Focused ultrasound has emerged as a key tool for neurologic disorders. In this focused review, we discuss the utility in disrupting the blood brain barrier to maximize treatment. This can facilitate creating direct coagulative lesions and aid in the administration of chemotherapy. Furthermore, it can facilitate neuromodulation when used in pulse sequencing.
Dietary practice among mainstream bengali population and ethnic communities in bangladesh
Bangladesh has a number of ethnic minor group population and they lead their life in great ethnic diverse fashion [1]. They constitute about 1% of total population [1]. They are distributed in scattered way all over the hilly, riverine and dense forest region of the country [1].
Portrayal of substance use in media and its effects on substance use disorders among youth
A variety of behavioral, environmental, developmental, and genetic factors have been documented as contributing to the development of Substance use disorders (SUDs) in youth. For example, it has been suggested that things such as the perceived availability of substances, familial history of anti-social behavior, personal attitudes favorable towards drug use all have strong correlations to the development of substance use in youth.
Predictors of relapse in alcohol use disorder: identifying individuals most vulnerable to relapse
Alcohol Use Disorder (AUD) is described as a chronic relapsing condition with definitive behavioral markers and is characterized by repeated drug intake despite severe negative consequences [1]. With 12-month prevalence rates at 14% and lifetime estimates of 29% [2], it is clear that AUD adversely and substantially affects individual and societal health [3]. Recognized clinically as affecting decision making, relationships, and neurological function [4]
Glucan and Vitamin D supplementation showed synergy in improvements of the immune response against an influenza challenge in mice
Influenza infection remains a serious health problem throughout the world. Unfortunately, current medicine offers no real treatment or protection, moving our attention to alternative options. In this study we aimed to evaluate the possible effects of a combination of glucan and vitamin C on immunosuppression caused by influenza infection.
Common patient positioning in gastrointestinal endoscopy
Gastrointestinal endoscopic procedure is routinely utilized for diagnosis and treatment of gastrointestinal abnormalities. The optimal positioning for this procedure is to offer the best operative access while minimizing potential risk to the patient. Changing the patient's position could improve the probabilities of successful endoscopy. However, each position carries some degrees of risk and this is applied in each procedure. Commonly approved positions include lateral, prone and supine. This article addresses the common patient positions used for gastrointestinal endoscopic procedures.
Ocular surface squamous neoplasia treated with topical chemotherapy
A man in his 90s presented to clinic with a conjunctival lesion on the right eye noticed two months prior. The patient denied pain but endorsed worsening blurry vision. The patient’s past medical history was significant for skin cancer on the right ear removed 3 years ago, and a history of ocular surface lesion removal on one eye approximately 20 years ago that was negative for any neoplasia. Slit lamp photograph revealed a gelatinous and opalescent lesion suspicious for ocular surface squamous neoplasia (OSSN) and the high-resolution optical coherence tomography (HROCT) cut (arrow)
Detection of some synthetic cannabinoids (FUB-AMB and AB-FUBINACA) in blood and urine using Gas Chromatography-mass spectrometry liquid–liquid extraction
In recent years, various types of synthetic cannabinoids have become widely distributed and are causing social and health problems in most parts of the world. Synthetic cannabinoids are currently the largest group of new psychoactive substances. Those that have been subjected to legal control are replaced by newer controlled and uncontrolled substances.
Drug delivery via the upper nasal space: A novel route for anesthesiologists, intensivists and emergency department physicians?
Many drugs are effective systemically, but slow onset of non-intravenous routes of administration may limit their clinical utility. While anesthesiologists usually have intravenous (IV) access for drug delivery, other healthcare professionals in less controlled situations such as acute crises in the emergency room, critical care settings, or urgent needs in the community, may need non-invasive drug delivery [1].