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The Neuroscience Chronicles
ISSN: 2767-3405
Volume 1, Issue 1, p1-17
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Role of Ginseng in therapeutic management of Alzheimer’s Disease
While much of research progress has been achieved in last century on Alzheimer’s Disease (AD), the conclusive therapy for the same is still unachieved. Several lines of therapeutic regimes have been introduced, which basically act on slowing down the disease progression.
Neurosci Chron, 2020, Volume 1, Issue 1, p1-3 | DOI: 10.46439/Neuroscience.1.001Association of COVID-19 coronavirus and Kawasaki syndrome like features in 1-5 years old children
In the nightmare of the coronavirus pandemic that is spreading around the world, parents could take comfort in one thing - early reports that the virus mysteriously spares children, even though this often leads to critical illness in older people. An article published in the Journal “Pediatrics”, based on 2,143 young people in China, provides the most comprehensive evidence of the spread of the virus among children, and there is bad news and good news [1].
Neurosci Chron, 2020, Volume 1, Issue 1, p4-5 | DOI: 10.46439/Neuroscience.1.002Parkinson’s disease: cell therapy vs. gene therapy
Parkinson’s disease (PD) is the second most common neurodegenerative disease, manifesting as a characteristic movement disorder with a number of additional non-motor features. The pathological hallmark of PD is the presence of intra-neuronal aggregates of a-synuclein (Lewy bodies). The movement disorder of PD occurs largely due to loss of dopaminergic neurons of the substantia nigra, resulting in striatal dopamine depletion.
Neurosci Chron, 2020, Volume 1, Issue 1, p6-10 | DOI: 10.46439/Neuroscience.1.003MicroRNA silencing: A promising therapy for Alzheimer’s disease
Alzheimer’s disease (AD) is a global health crisis currently afflicting ~6 million Americans (and ~40 million people worldwide). By the middle of the century, these numbers will stagger by ~16 million Americans (and ~152 million people worldwide) suffering from AD, if breakthrough disease-modifying treatments are not discovered.
Neurosci Chron, 2020, Volume 1, Issue 1, p11-15 | DOI: 10.46439/Neuroscience.1.004Overcrowding modulates the response of adolescents to psychoactive drugs
Overcrowding is a growing problem that prevails in the urban areas of both developing and developed countries. It is considered as psycho-social stress that affects the behavior and physiology of individuals and societies [1].
Scientific awareness of overcrowding stress systematically started in the 1960s with the early experiments of John B. Calhoun using the so-called “rat utopia” and the theory of “behavioral sink” [2]. Depending on Calhoun’s experiments, connections between the model of rodent colonies and the arising problems of crowded cities were extrapolated [3].
Role of Ginseng in therapeutic management of Alzheimer’s Disease
While much of research progress has been achieved in last century on Alzheimer’s Disease (AD), the conclusive therapy for the same is still unachieved. Several lines of therapeutic regimes have been introduced, which basically act on slowing down the disease progression.
Parkinson’s disease: cell therapy vs. gene therapy
Parkinson’s disease (PD) is the second most common neurodegenerative disease, manifesting as a characteristic movement disorder with a number of additional non-motor features. The pathological hallmark of PD is the presence of intra-neuronal aggregates of a-synuclein (Lewy bodies). The movement disorder of PD occurs largely due to loss of dopaminergic neurons of the substantia nigra, resulting in striatal dopamine depletion.
MicroRNA silencing: A promising therapy for Alzheimer’s disease
Alzheimer’s disease (AD) is a global health crisis currently afflicting ~6 million Americans (and ~40 million people worldwide). By the middle of the century, these numbers will stagger by ~16 million Americans (and ~152 million people worldwide) suffering from AD, if breakthrough disease-modifying treatments are not discovered.
Overcrowding modulates the response of adolescents to psychoactive drugs
Overcrowding is a growing problem that prevails in the urban areas of both developing and developed countries. It is considered as psycho-social stress that affects the behavior and physiology of individuals and societies [1].
Scientific awareness of overcrowding stress systematically started in the 1960s with the early experiments of John B. Calhoun using the so-called “rat utopia” and the theory of “behavioral sink” [2]. Depending on Calhoun’s experiments, connections between the model of rodent colonies and the arising problems of crowded cities were extrapolated [3].
Parkinson’s disease pathogeny and treatments: a narrative review
Parkinson’s disease is a multifaceted illness that requires interdisciplinary approach to be fully addressed. The etiology of the disease is not completely understood, but genetic and environmental cues play important roles. Histological hallmarks of the disease are the accumulation of alpha-synuclein aggregates, mitochondrial changes and loss of dopaminergic neurons in the substantia nigra. The dopaminergic shortage leads to many motor and non-motor symptoms that affect patient quality of life. Current treatments are symptomatic only, for none can stop disease progression or cure it. Among them are intense physical exercise, dopaminergic drug intake, deep brain stimulation and the use of medical cannabis.
Late complications of children and adolescents after allogeneic hematopoietic stem cell transplantation: An integrative review
Patients undergoing Allogeneic hematopoietic stem cell transplantation (allo HSCT) can develop late complications that limit their functioning and reduce their quality of life. This phase requires nursing-specific knowledge for care plans that can meet the patient’s real needs. For this reason, the purpose of this review is to compile the data available in the literature on late complications present in the follow-up of pediatric and adolescent patients after allo HSCT.
Cell therapy with autologous mesenchymal stem cells for premature baby with neonatal sepsis and bronchopulmonary dysplasia: Case report
Bronchopulmonary dysplasia (BPD) remains the most common disease in premature newborns, associated with immature lung injury under the influence of supplemental oxygen and mechanical ventilation. “Classical BPD” is observed in premature newborns who have not received surfactant treatments. It is characterized by pulmonary fibrosis due to oxygen toxicity and volumetric/barometric trauma caused by mechanical ventilation. A new or "mild" form of BPD is observed in children born at 29 weeks of gestation, and is characterized by disordered pulmonary development due to prematurity.
Effect of senescence on behavior of mesenchymal stromal/stem cells
During lifespan the homeostasis and repair of organs and tissues are guaranteed by the adult stem cell population. Among them, mesenchymal stromal cells (MSCs), which contain a subpopulation of multipotent stem cells, are emerging as promising candidates for cell therapy of numerous diseases. MSCs are non-hematopoietic cells capable of self-renewal and differentiation into osteocytes, adipocytes, and chondrocytes.
Approach to testicular adrenal rest tumors in children and adolescents with congenital adrenal hyperplasia
Congenital adrenal hyperplasia (CAH) is a disorder affecting cortisol biosynthesis in the adrenal cortex [1]. 21-hydroxylase deficiency is the most frequent reason for CAH, with an incidence between 1:10.000 and 1:20.000 [2]. Due to the lack of enzyme function, patients with any enzyme deficiency cannot synthesize cortisol effectively.
The role of psychoeducation and yoga in reducing the burden of family caregivers of people with Alzheimer’s disease
The continuous increase in the elderly population and chronic health conditions present significant challenges to healthcare systems, particularly in developing countries. Among these conditions, dementia, particularly Alzheimer's disease (AD), is one of the most concerning, causing cognitive decline, behavioral changes, and progressive dependence on family caregivers.
Oilfield workers’ job satisfaction: A study of social support and work stress
This study aimed to investigate and identify the correlates of job satisfaction of large-scale industry employees. We randomly selected 299 employees from an oilfield in the East of China and administered a questionnaire survey. We found that when other variables controlled for, the conflict with leaders and the discontent with management was negatively related to job satisfaction, and conflict with colleagues was positively associated with job satisfaction. On the other hand, the workload was not an important influencing factor.
Complex actions of amyloid beta on hippocampal neurogenesis in Alzheimer’s disease pathogenesis
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and memory impairment. One of the key pathological hallmarks of AD is the accumulation of amyloid beta (Aβ), a peptide derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases .
Clinical and urodynamic findings in children and adolescents with refractory neurogenic bladder undergoing augmentation cystoplasty
Augmentation cystoplasty (AC) is a surgical procedure for patients with refractory neurogenic bladder (NB). This study aimed to evaluate urinary incontinence (UI), vesicoureteral reflux (VUR), and urodynamic parameters in patients’ post-AC and compare these results to preoperative data.