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The Neuroscience Chronicles
ISSN: 2767-3405
Volume 3, Issue 1, p1-11
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
The role of aromatic stacking in drug-drug interactions
Having studied and worked in the fields of pharmacology and structural biology my first reaction to reading an article or attending a lecture about a class of chemical compounds or biomolecules regardless of whether they are nucleotides, proteins or lipids is to look up their structure or sequence, as the chemical structure of molecules is what defines their character, that is their mechanism of action. Most cancer therapeutic agents such as Taxol (paclitaxel) which is widely used to target solid tumors are rich in aromatic structures. These patients are often depressed and are on psychotropic medications, which also contain two or more aromatics. It is unknown whether these two groups of compounds directly interact.
Neurosci Chron, 2022, Volume 3, Issue 1, p1-2 | DOI: 10.46439/Neuroscience.3.016Mg+2 ions mediate the interaction of intrinsically disordered nascent chains with the ribosome: implications for protein folding and aggregation in the early stages of protein life
During the last few decades, the ribosome has been regarded primarily as a major cell player devoted to the catalysis of protein biosynthesis during translation [1-5]. It is therefore not surprising that several processes related to translation exploit the ribosome as a central hub. For instance, it is well-known that many events related to translational regulation are mediated by interactions between the ribosome and initiation, elongation or termination factors [6-9]. In addition, the ribosome is involved in mRNA-code recognition and proofreading [10-12] as well as in the control of translation rates via interactions with mRNA codons bearing high- and low-frequency [13-15] and associated with variable tRNA abundance within the translation machinery [16-18].
Neurosci Chron, 2022, Volume 3, Issue 1, p3-5 | DOI: 10.46439/Neuroscience.3.017Omics analysis of uveal melanoma: Leukocyte gene signatures reveal novel survival distinctions and indicate a prognostic role for cytolytic activity scoring
The significant metastatic potential of uveal melanoma (UVM) lends to high mortality. Even with successful local tumor treatment, many patients will develop metastatic disease. The present study aims to elucidate the relationship between tumor-infiltrating immune cell (TIIC) diversity and survival to identify potential therapeutic targets and improve UVM prognosis.
Neurosci Chron, 2022, Volume 3, Issue 1, p6-11 | DOI: 10.46439/Neuroscience.3.018The role of aromatic stacking in drug-drug interactions
Having studied and worked in the fields of pharmacology and structural biology my first reaction to reading an article or attending a lecture about a class of chemical compounds or biomolecules regardless of whether they are nucleotides, proteins or lipids is to look up their structure or sequence, as the chemical structure of molecules is what defines their character, that is their mechanism of action. Most cancer therapeutic agents such as Taxol (paclitaxel) which is widely used to target solid tumors are rich in aromatic structures. These patients are often depressed and are on psychotropic medications, which also contain two or more aromatics. It is unknown whether these two groups of compounds directly interact.
Mg+2 ions mediate the interaction of intrinsically disordered nascent chains with the ribosome: implications for protein folding and aggregation in the early stages of protein life
During the last few decades, the ribosome has been regarded primarily as a major cell player devoted to the catalysis of protein biosynthesis during translation [1-5]. It is therefore not surprising that several processes related to translation exploit the ribosome as a central hub. For instance, it is well-known that many events related to translational regulation are mediated by interactions between the ribosome and initiation, elongation or termination factors [6-9]. In addition, the ribosome is involved in mRNA-code recognition and proofreading [10-12] as well as in the control of translation rates via interactions with mRNA codons bearing high- and low-frequency [13-15] and associated with variable tRNA abundance within the translation machinery [16-18].
Omics analysis of uveal melanoma: Leukocyte gene signatures reveal novel survival distinctions and indicate a prognostic role for cytolytic activity scoring
The significant metastatic potential of uveal melanoma (UVM) lends to high mortality. Even with successful local tumor treatment, many patients will develop metastatic disease. The present study aims to elucidate the relationship between tumor-infiltrating immune cell (TIIC) diversity and survival to identify potential therapeutic targets and improve UVM prognosis.
Breaking malignant nuclei as a non-mitotic mechanism of taxol/paclitaxel
Discovered in a large-scale screening of natural plant chemicals, Taxol/paclitaxel and the taxane family of compounds are surprisingly successful anti-cancer drugs, used in treatment of the majority of solid tumors, and especially suitable for metastatic and recurrent cancer. Paclitaxel is often used in combination with platinum agents and is administrated in a dose dense regimen to treat recurrent cancer.