American Journal of Aging Science and Research

Few studies have been conducted on the relationship between “outside-residing” resilience characteristics and the risk of developing drug use disorder later in life. These characteristics include responsive and caring parenting, household routines involving regular family meals and bedtime routines, social support from peers, participation in organized activities, and religious service attendance.

Many drugs are effective systemically, but slow onset of non-intravenous routes of administration may limit their clinical utility. While anesthesiologists usually have intravenous (IV) access for drug delivery, other healthcare professionals in less controlled situations such as acute crises in the emergency room, critical care settings, or urgent needs in the community, may need non-invasive drug delivery [1].

Within human tissue, oxygen concentrations are considerably less than the 21% O2 concentrations found in ambient air and is termed physiological hypoxia. Typically, the partial pressure of oxygen
(pO2) of human tissue lies between 1% and 14%, with considerable local and regional variations

The purpose of this document is to provide a unique white paper on the use of different anesthetic drugs and the key clinical pearls for ensuring patient safety in humans. This paper is designed to be a convenient guide that can be placed in work rooms for residents and medical school trainees to improve their learning and to provide reminders about drug-drug interactions.

According to the United Nations, to date the number and proportion of elderly grows much faster than in other age groups. The increase in the total number of elderly persons in the population of the globe makes the actual problems of social and economic consequences of population ageing. The issue of ensuring the quality of life of older people becomes an important and urgent task of the state.

Overcrowding is a growing problem that prevails in the urban areas of both developing and developed countries. It is considered as psycho-social stress that affects the behavior and physiology of individuals and societies [1]. 
Scientific awareness of overcrowding stress systematically started in the 1960s with the early experiments of John B. Calhoun using the so-called “rat utopia” and the theory of “behavioral sink” [2]. Depending on Calhoun’s experiments, connections between the model of rodent colonies and the arising problems of crowded cities were extrapolated [3].

In recent years, stress and stress-coping mechanisms constitute a growing public healthcare issue concerning modern society. Experiencing stress engenders a great complex mechanism named stress response, which consists of a rapid release of catecholamines by the sympathetic nervous system, followed by a slower response in which hormones, mainly glucocorticoids (GCs), are synthesized and released to the bloodstream.

We are writing to promote a novel Bayesian dynamic borrowing approach, the empirical profile Bayesian estimation, in the published article "Yaoshi Wu, Jianan Hui, Qiqi Deng. Empirical profile Bayesian estimation for extrapolation of historical adult data to pediatric drug development. Pharmaceutical statistics 2020; 19; 787-802. http://dx.doi.org/10.1002/pst.2031."

Having studied and worked in the fields of pharmacology and structural biology my first reaction to reading an article or attending a lecture about a class of chemical compounds or biomolecules regardless of whether they are nucleotides, proteins or lipids is to look up their structure or sequence, as the chemical structure of molecules is what defines their character, that is their mechanism of action. Most cancer therapeutic agents such as Taxol (paclitaxel) which is widely used to target solid tumors are rich in aromatic structures. These patients are often depressed and are on psychotropic medications, which also contain two or more aromatics. It is unknown whether these two groups of compounds directly interact.

Global aging has led to a greater proportion of older adults and is one of the factors contributing to the increase in annual healthcare expenditure. People live longer despite the presence of chronic health conditions. To offset rising healthcare costs, it is expected that older adults continue to live independently at home for as long as possible.

Today, roughly 30% of the global energy needs are met by coal, according to the International Energy Agency. Over the past few decades, although many measures have been taken to protect workers against dust inhalation, coal workers’ pneumoconiosis (CWP) remains to be a significant threat to public health, especially in developing countries.

Background: Osteoarthritis, a widespread highly painful oftentimes incapacitating joint disease continues to impose immense personal and societal challenges among adults of all ages, especially older adults.
Objective: This review aimed to describe the extent to which older adults with osteoarthritis may suffer excess disability, compared to healthy age-matched older adults, and why this is important to note and prevent in the context of the novel COVID-19 corona virus pandemic.

The world is witnessing a rapid demographic shift towards an aging population. People are living longer due to advances in education, technology, medicine, food distribution, and sanitary conditions. According to the 2011 census data, Nepal had a total of 2,154,003 elderly 60 years and above which accounts for 8.1 percent of the total population of Nepal.

Objectives: Physical function impairment can cause great stress to older adults. The purpose of the study is to investigate the association between self-reported and directly-observed physical function on perceived stress among U.S. Chinese older adults. 

As the field of immunology continues to unravel the complexities of immune responses and their intersection with therapeutic interventions, the emergence of innovative drug delivery systems has sparked new avenues of exploration. 

The design of safe drug delivery systems that locally allow efficacious concentration of curative molecules has become the latest frontier in nanomedicine. It usually relies on the entrapment of drugs into micro/nano carriers guaranteeing for the controlled release of the drugs while protecting them from degradation and fast clearance.

Antibiotic misuse contributes to the emergence of multidrug-resistant organisms, resulting in infections that cause over one million deaths annually [1-3]. Therefore, there is an urgent need to develop new antimicrobial methods. Traditional antibiotic therapy is often incomplete due to the emergence of drug-resistant strains, leading to relapse. 

Amyloid transformation under laboratory conditions is achieved by shaking an aqueous solution of any protein. The shaking time varies significantly, demonstrating the variable degree of ease of structural transformation in a given protein. The structural specificity that distinguishes amyloid forms from biologically active proteins is the flatness (two-dimensionality) of the form of each chain in the amyloid fibril.

Machine learning (ML) is a branch of artificial intelligence that uses an algorithm to process the data, retrieve valuable information, learn from it, find a pattern, and make predictions. Manual data analyses suffer from several disadvantages including it is time-consuming and subject to error.

The continuous increase in the elderly population and chronic health conditions present significant challenges to healthcare systems, particularly in developing countries. Among these conditions, dementia, particularly Alzheimer's disease (AD), is one of the most concerning, causing cognitive decline, behavioral changes, and progressive dependence on family caregivers.