Journal of Pain Research and Management

2025

Volume 1, Issue 1, p1-117

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Research Article Open Access

The effect of preoperative in-person education on the pain severity of patients undergoing coronary artery bypass graft (CABG) surgery

Roghayeh Sadeghi, Touraj Babaee, Hooman Bakhshandeh, Maziar Naderi

Pain is one of the most common symptoms experienced by patients undergoing coronary artery bypass graft (CABG) surgery. Adequate pain management is critical to the well-being and overall recovery of these patients. This study aimed to evaluate the effect of preoperative in-person pain education on the pain severity experienced by patients undergoing CABG surgery in Rajaie Cardiovascular, Medical and Research Center in Tehran in 2022.

J Pain Res Manag, 2025, Volume 1, Issue 1, p1-10 | DOI: 10.46439/Painresearch.1.001

Research Article Open Access

Fibromyalgia, perfectionism, and interpersonal style. Further evidence for a person-centered approach

Frank Maes, Greet Vanaerschot, Els Goossens, Boudewijn Van Houdenhove

Fibromyalgia (FM) is usually considered a ‘medically unexplained’ chronic pain disorder with no known causal treatment. The disorder is also referred to as a ‘functional somatic syndrome’ in which psychological factors are believed to play an important role. According to recent criteria of the American College of Rheumatology (ACR), the main symptom is unexplained widespread pain for at least 3 months; associated symptoms include fatigue, impaired concentration, non-restorative sleep, stimulus intolerance, post-exertional malaise, and various complaints related to neuro-vegetative dysfunction.

J Pain Res Manag, 2025, Volume 1, Issue 1, p11-18 | DOI: 10.46439/Painresearch.1.002

Research Article Open Access

Alpha 2 adrenoceptors but not GABA participate in electroacupuncture-induced orofacial antinociception at ST36 point in rats

Renato Teixeira Almeida, Giovane Galdino, Andrea Castro Perez, Thiago Roberto Romero, Igor Dimitri Gama Duarte

Orofacial pain represents a significant portion of the complaints from patients seeking treatment at pain management centers worldwide. Although the treatment for orofacial pain is primarily pharmacological, there has been an increase in reports showing significant clinical results from non-pharmacological therapies, including electroacupuncture (EA).

J Pain Res Manag, 2025, Volume 1, Issue 1, p19-27 | DOI: 10.46439/Painresearch.1.003

Original Research Open Access

Exploring AI for pain research management: A deep dive investigative exploration

Zarif Bin Akhtar

Chronic pain still remains a complex healthcare challenge impacting millions of people worldwide, demanding innovative solutions to enhance patient outcomes and alleviate the burden towards healthcare systems. This research investigates the transformative potential of Artificial Intelligence (AI) in chronic pain management, emphasizing its application in personalized diagnostics, predictive modeling, and optimized treatment strategies.

J Pain Res Manag, 2025, Volume 1, Issue 1, p28-42 | DOI: 10.46439/Painresearch.1.004

Review Article Open Access

A review of waveform and paradigm variations of spinal cord stimulation for the treatment of complex regional pain syndrome

Vahid Mohabbatii, Parsa Mohabbati, Mohammadkazem Papan

Complex Regional Pain Syndrome (CRPS) is a challenging condition marked by intense and often long-lasting pain, typically occurring in a limb following an injury. Traditional treatment approaches might not always offer significant pain relief, prompting the investigation of advanced treatments like Spinal Cord Stimulation (SCS).

J Pain Res Manag, 2025, Volume 1, Issue 1, p43-56 | DOI: 10.46439/Painresearch.1.005

Mini Review Open Access

Balancing autonomic nervous system activity through hypnosis clinical implications for pain therapy

Giuseppe De Benedittis

Hypnosis, a clinically valuable therapeutic modality, is increasingly recognized for its efficacy in treating a spectrum of psychological and somatic disorders, including pain. Its influence extends beyond central nervous system processes to encompass the autonomic nervous system (ANS), thereby affecting peripheral physiological responses.

J Pain Res Manag, 2025, Volume 1, Issue 1, p57-61 | DOI: 10.46439/Painresearch.1.006

Original Research Open Access

Voices in the night: Sleep paralysis & The intersection of brain, trauma, traditions

Zarif Bin Akhtar

Sleep Paralysis (SP) is a complex and multifaceted phenomenon situated at the intersection of neurobiology, psychiatry, genetics, and cultural belief systems. This study offers a comprehensive investigation into SP, integrating findings from neurophysiological, psychological, and sociocultural domains. Neurobiological evidence highlights disruptions during the rapid eye movement (REM) sleep cycle—specifically the persistence of REM atonia into wakefulness—as a core mechanism underlying SP, often accompanied by vivid hallucinations and sensory distortions.

J Pain Res Manag, 2025, Volume 1, Issue 1, p62-74 | DOI: 10.46439/Painresearch.1.007

Research Article Open Access

Evaluation of the role of potassium and chloride channels in peripheral antinociception induced by epoxyeicosatrienoic acids (EETs) in mice

Flávia Cristina de Sousa Fonseca, Walace Cássio Pinto Barra, Andrea Castro Perez, Thiago Roberto Romero, Igor Dimitri Gama Duarte

The hyperpolarization of neuronal membranes through the activation of potassium and chloride channels is a significant mechanism involved in the antinociceptive effects of various drugs. Thus, in this study, we aimed to determine whether potassium or chloride channels mediate the peripheral antinociceptive effects of epoxyeicosatrienoic acids (EETs). The mechanical paw pressure test was utilized as an algesimetric method.

J Pain Res Manag, 2025, Volume 1, Issue 1, p75-82 | DOI: 10.46439/Painresearch.1.008

Research Article Open Access

Prevalence and management of pain disorders among patients of different stages of life at cape coast teaching hospital, Ghana

Ernest Obese, Douglas Arthur, Oluwayemisi Esther Ekor, Ivan Eduku Mozu, Ransford Kumah, James Kojo Prah, Jerry Kwesi Kumah Eshun, Kwame Ofori, Mawuli Kotope Gyakobo, Elvis Ofori Ameyaw

Pain represents a significant global health issue with serious consequences for both individual well-being and societal functioning. The International Association for the Study of Pain (IASP) characterizes pain as an "unpleasant sensory and emotional experience linked to actual or potential tissue damage".

J Pain Res Manag, 2025, Volume 1, Issue 1, p83-93 | DOI: 10.46439/Painresearch.1.009

Research Article Open Access

Trauma and treatment: Pain management in Puerto Rican elders visiting the emergency department

Francisco Lasanta Gorbea, Itzamar Pastrana, Abner Limardo-Irizarry, Tania Vega, Laura Lebron, Edgardo Martínez- Berdecia, Javier Torres-Acevedo, Miguel Agrait-González, Fabian Ramírez-Rivera

As of 2024, adults aged 65 and older account for over 10% of the global population, nearly double the 1974 figure and still rising. In the island of Puerto Rico, the proportion of older adults has increased greatly, from approximately 13% of the population being over 65 years in 2014, to 24.6% of the population in 2024.

J Pain Res Manag, 2025, Volume 1, Issue 1, p94-99 | DOI: 10.46439/Painresearch.1.010

Commentary Open Access

Diagnosis in the mist: Reflections on a misdiagnosed case of invasive pulmonary aspergillosis

Yongfen Zeng, Zhuqiang Cheng

This paper analyzes a misdiagnosed case of invasive pulmonary aspergillosis (IPA) presenting with left upper limb pain as an atypical symptom, exploring cognitive blind spots in clinical diagnosis, limitations in imaging and laboratory examinations, and therapeutic challenges. It emphasizes the importance of multidisciplinary collaboration in complex cases.

J Pain Res Manag, 2025, Volume 1, Issue 1, p100-102 | DOI: 10.46439/Painresearch.1.011

Commentary Open Access

Beyond prayer: Expanding the understanding of quality of life in Tanzanian palliative care

Sonia Nada

The recently published study “Religious practices and quality of life in palliative care: insights from Tanzania” has brought to the forefront the indispensable role of spiritual practices in supporting patients with advanced cancer. The overwhelming demand for prayer and faith-based engagement demonstrates how religion provides meaning, resilience, and comfort in the face of terminal illness.

J Pain Res Manag, 2025, Volume 1, Issue 1, p103-104 | DOI: 10.46439/Painresearch.1.012

Original Research Open Access

The pains of parentification: A cross-sectional comparison between Belgian women with fibromyalgia, rheumatoid arthritis, depression and healthy controls

Frank Maes, Jesse Berwouts, Greet Vanaerschot

This controlled cross-sectional study investigated the prevalence of different types of parentification in women with fibromyalgia (FM) compared to women with rheumatoid arthritis (RA), healthy controls (HC) and women with depression or anxiety disorder (AD). The study also examined associations with maladaptive interpersonal styles (subjugation, approval seeking, self-sacrifice).

J Pain Res Manag, 2025, Volume 1, Issue 1, p105-117 | DOI: 10.46439/Painresearch.1.013

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