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Journal of Cellular and Molecular Immunology

ISSN: 2833-1141

2022

Volume 1, Issue 1, p1-58

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Short Communication Open Access

Mass food challenges in a vacant COVID-19 step-down facility: reflections on the management of anaphylaxis

Jason Foran, David Coghlan

A popular western misconception dating back to at least the time of President John F Kennedy is that one of the Chinese characters in the word “crisis” means opportunity. The manuscript
“Management of anaphylaxis in children undergoing oral food challenges in an adapted COVID-19 field hospital” [1].

J Cell Mol Immunol, 2022, Volume 1, Issue 1, p1-4 | DOI: 10.46439/immunol.1.001
Editorial Open Access

CD4+Foxp3+Helios+regulatory T cells: Role in immunostasis and clinical applications

Castillo-Aleman YM, Bencomo-Hernandez AA, Ventura-Carmenate Y

Since Gershon and Kondo’s initial description of suppressor T cells as antigen-specific T cells that regulate immune responses [1], several advances have taken place on the biology and potential applications of regulatory T cells (Tregs) in clinical settings. After that, Sakaguchi et al.

J Cell Mol Immunol, 2022, Volume 1, Issue 1, p5-7 | DOI: 10.46439/immunol.1.002
Commentary Open Access

T helper cells: Top targets for Systemic Lupus Erythematosus treatment?

Haideh Namdari, Farhad Rezaei, Farzad Parvizpour

In the original research article, Parisa R et al. demonstrated that the induction of lupus-like autoimmune syndrome in BALB/c Mice caused disturbance in splenic T cell subpopulations. This study also elucidated those other mechanisms, apart from disturbance in T cells balance, may be responsible for the development of the disease’s symptoms [1].

J Cell Mol Immunol, 2022, Volume 1, Issue 1, p8-11 | DOI: 10.46439/immunol.1.003
Commentary Open Access

Vaccine for leishmaniasis: New era of CRISPR generated Live attenuated dermotropic Leishmania

Kamaleshwar Singh, Swarnendu Kaviraj, Subir Karmakar, Sanjay Singh

Using CRISPR gene-editing technology, researchers have generated a live attenuated centrin gene deleted Leishmania major parasites (LmCen-/-) which are able to protect against visceral leishmaniasis caused by Leishmania donovani parasite.

J Cell Mol Immunol, 2022, Volume 1, Issue 1, p12-16 | DOI: 10.46439/immunol.1.004
Commentary Open Access

Vaccination, politics and COVID-19 impacts: update

Don Albrecht

In an earlier manuscript, the author found a strong relationship between political views, vaccination levels and COVID-19 death rates. This study revealed that in U.S. counties where large proportions of voters cast their ballot for Donald Trump in the 2020 presidential election, vaccination levels were lower and COVID-19 death rates were higher.

J Cell Mol Immunol, 2022, Volume 1, Issue 1, p17-19 | DOI: 10.46439/immunol.1.005
Review Article Open Access

Immunotherapy as a treatment to confront the ongoing opioid epidemic- A review

Nachum Dafny

Substance use disorders continue to be major medical and social problems worldwide. The use of opiate has grown substantially over the past three decades reaching the dimensions of a global epidemic. Current drug treatments have many limitations: long treatment times, dependency on treatment medications, relapses after treatment, high costs of treatment, and non-adherence by affected persons.

J Cell Mol Immunol, 2022, Volume 1, Issue 1, p20-27 | DOI: 10.46439/immunol.1.006
Commentary Open Access

DNA hyper methylation editing of T cell receptor signaling and the fellow molecules: a promise strategy of predicting acquired immune checkpoint inhibitors (ICIs) resistance

Zixin Hu, Huijuan Cui

The promising results of immune checkpoint inhibitors (ICIs) in tumors have changed the current treatment modality for cancer. ICIs response prediction is urgently needed for the personalized therapy approach. In the recent issue of the Journal of Oncology, Zixin Hu et al.

J Cell Mol Immunol, 2022, Volume 1, Issue 1, p28-31 | DOI: 10.46439/immunol.1.007
Case Report Open Access

Humoral immunodeficiency in a patient with Malan syndrome secondary to chromosome 19p13.2 microdeletions 

Amer Khojah, Ameera Bukhari

Malan syndrome (Sotos Syndrome 2, OMIM 614753) is a rare autosomal dominant overgrowth disorder caused by either chromosome 19p13.2/19p13.13 microdeletion or Nuclear Factor 1 X-Type (NFIX) gene haploinsufficiency. Symptoms typically appear in infancy and include dysmorphic features, seizures, and behavioral issues; however, the degree of immune system involvement is not clear.

J Cell Mol Immunol, 2022, Volume 1, Issue 1, p32-35 | DOI: 10.46439/immunol.1.008
Commentary Open Access

Unraveling the heterogeneity of chronic inflammatory diseases: Lessons learned from axial spondyloarthritis (axSpA)

Florence W.L. Tsui, Robert D. Inman

A key feature of chronic inflammatory disease is heterogeneity. For clinicians, this poses problems not only in disease diagnosis and assessment, but also in providing personalized disease management for the patients. There are at least two explanations for disease heterogeneity: First, different patient subgroups have different etiologies and subsequent pathways involvement, leading to a similar clinical outcome.

J Cell Mol Immunol, 2022, Volume 1, Issue 1, p36-39 | DOI: 10.46439/immunol.1.009
Research Article Open Access

Late complications of children and adolescents after allogeneic hematopoietic stem cell transplantation: An integrative review

Priscila de Oliveira da SILVA, Gabrielli Mottes ORLANDINI, Mariana Bohns MICHALOWSKI, Liane Esteves DAUDT

Patients undergoing Allogeneic hematopoietic stem cell transplantation (allo HSCT) can develop late complications that limit their functioning and reduce their quality of life. This phase requires nursing-specific knowledge for care plans that can meet the patient’s real needs. For this reason, the purpose of this review is to compile the data available in the literature on late complications present in the follow-up of pediatric and adolescent patients after allo HSCT.

J Cell Mol Immunol, 2022, Volume 1, Issue 1, p40-47 | DOI: 10.46439/immunol.1.010
Review Article Open Access

The strange case of nurse cells: Dr. Jekyll or Mr. Hyde?

Elisabetta Dondi , Nadine Varin-Blank

In developmental biology and physiology of reproduction the term nurse cells refers to cells which provide feeding, support, and stability to their neighboring cells. The notion of nurse cell is used in several unrelated ways in various scientific fields, such as parasitology, mycology, invertebrate and vertebrate development. In this review, we focus on “nurse cells” described to support hemopoietic cell differentiation which can act as a double-edged sword in normal versus pathological conditions. Particularly, the nurturing capacity of stromal cells to assist the differentiation and survival of normal cells within both the bone marrow or the synovium can turn to detrimental effects.

J Cell Mol Immunol, 2022, Volume 1, Issue 1, p48-58 | DOI: 10.46439/immunol.1.011
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Vaccination, politics and COVID-19 impacts: update

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DNA hyper methylation editing of T cell receptor signaling and the fellow molecules: a promise strategy of predicting acquired immune checkpoint inhibitors (ICIs) resistance

The promising results of immune checkpoint inhibitors (ICIs) in tumors have changed the current treatment modality for cancer. ICIs response prediction is urgently needed for the personalized therapy approach. In the recent issue of the Journal of Oncology, Zixin Hu et al.

Humoral immunodeficiency in a patient with Malan syndrome secondary to chromosome 19p13.2 microdeletions 

Malan syndrome (Sotos Syndrome 2, OMIM 614753) is a rare autosomal dominant overgrowth disorder caused by either chromosome 19p13.2/19p13.13 microdeletion or Nuclear Factor 1 X-Type (NFIX) gene haploinsufficiency. Symptoms typically appear in infancy and include dysmorphic features, seizures, and behavioral issues; however, the degree of immune system involvement is not clear.

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