Journal of Cellular and Molecular Immunology

2023

Volume 2, Issue 1, p1-44

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Commentary Open Access

BRCA1 and BRCA2 mutation variants in early breast cancer confer added prognostic information

Nuhad K. Ibrahim, Banu Arun

Metastatic breast cancer to brain carries poor prognostic features with increased risks of occurrence in Tripple- negative and HER- positive breast tumors. In addition, tumors with mutated BRCA tumors, carry as well increased metastatic incidence. However, new clinical evidence suggest distinct clinical features between BRCA1 or BRCA2 mutated breast cancer and brain metastasis.

J Cell Mol Immunol, 2023, Volume 2, Issue 1, p1-5 | DOI: 10.46439/immunol.2.012

Commentary Open Access

Immune checkpoint inhibitor therapy-associated myocarditis – Toward identification of an immune signature that can improve diagnosis

Pourya Yarahmadi, Patricia Nguyen

Immune checkpoint inhibitors (ICI) have emerged as promising treatment options for many cancers. ICIs exert their therapeutic effects by targeting immune inhibitory molecules on T-cells in adaptive immunity, such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell death 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1).

J Cell Mol Immunol, 2023, Volume 2, Issue 1, p6-8 | DOI: 10.46439/immunol.2.013

Commentary Open Access

Insight into the application of nicotinamide mononucleotide (NMN) to age-related disorders

Masaki Igarashi, Toshimasa Yamauchi

Numerous animal studies have shown that the decrease in the tissue Nicotinamide Adenine Dinucleotide (NAD+) levels during aging are closely related to age-related physiological decline and that the administration of NAD+ precursors restore NAD+ levels and promotes health and prolongs lifespan.

J Cell Mol Immunol, 2023, Volume 2, Issue 1, p9-13 | DOI: 10.46439/immunol.2.014

Commentary Open Access

Coal workers' serum immunoglobulins provide hints for pneumoconiosis

Zhaoguo Li, Junling Pang, Peiran Yang, Jing Wang, Huaping Dai

Today, roughly 30% of the global energy needs are met by coal, according to the International Energy Agency. Over the past few decades, although many measures have been taken to protect workers against dust inhalation, coal workers’ pneumoconiosis (CWP) remains to be a significant threat to public health, especially in developing countries.

J Cell Mol Immunol, 2023, Volume 2, Issue 1, p14-15 | DOI: 10.46439/immunol.2.015

Commentary Open Access

FXYD3-IL-17 positive feedback loop promotes psoriasis exacerbation

Meng Xia, Qingqing Wang

Psoriasis is primarily a chronic skin disease characterized by keratinocyte hyperplasia, as well as a systemic inflammatory disease associated with numerous comorbidities, including rheumatological psoriatic arthritis, cardiovascular and psychiatric complications. Approximately 2-3% of the global population is affected by psoriasis, and despite advances in the treatment, there are still limitations.

J Cell Mol Immunol, 2023, Volume 2, Issue 1, p16-18 | DOI: 10.46439/immunol.2.016

Commentary Open Access

Exploring Immune Cell Profiles and NLRP3 Gene Expression as Potential Diagnostic Markers in COVID-19 Patients: A Commentary

Maedeh Radandish, Nafiseh Esmaeil, Alireza Andalib

The COVID-19 pandemic caused by the SARS-CoV-2 virus continues to impact populations worldwide, emphasizing the need for improved diagnostic and treatment strategies. Understanding the immune response and identifying early diagnostic markers are crucial in this endeavor.

J Cell Mol Immunol, 2023, Volume 2, Issue 1, p19-21 | DOI: 10.46439/immunol.2.017

Commentary Open Access

Commentary on Aplasia cutis congenita in monozygotic twins: What should we do further?

Hui-Jun Lai, Ping-Ping Ma, Mei-Yan Lai, Hong-Wei Guo

Aplasia cutis congenita (ACC) is a rare congenital anomaly characterized by a localized or widespread lack of skin at birth. Most information about ACC exists as individual case reports and medium-sized studies. Recently, a study based on the European network of population-based registries for congenital anomalies (EUROCAT) showed that the scalp is the most common site of ACC (96.4%), and 33.8% of cases have related congenital abnormalities. Patau and Adams-Oliver syndromes are the most common among the associated chromosomal anomalies (88.3%) and the associated genetic syndromes (57.7%).

J Cell Mol Immunol, 2023, Volume 2, Issue 1, p22-24 | DOI: 10.46439/immunol.2.018

Commentary Open Access

The role of MRI in detecting and characterizing brain metastases from breast cancer

Sana Mohammadi, Sadegh Ghaderi

Brain metastases are a feared complication of breast cancer, occurring in 15-25% of patients and being associated with poor prognosis and reduced quality of life. Magnetic resonance imaging (MRI) is an advanced technique that uses powerful magnetic fields and radio waves to produce detailed three-dimensional (3D) images of the brain's neuroanatomy and any potential pathology, especially in the management of brain metastases.

J Cell Mol Immunol, 2023, Volume 2, Issue 1, p25-26 | DOI: 10.46439/immunol.2.019

Commentary Open Access

Unlocking the potential: Keto diet's impact on immunity, obesity, neurodegenerative diseases, and cardiovascular diseases

Vishakha Anand Pawar, Anuradha Tyagi, Vinay Kumar

An ancient proverb like “we are what we eat”, entails the significance and an influence of dietary habits and thereby nutrients on all living beings. A universal system encompasses various categories of classes that recognize consequences of various diets on immunity and thereby on the health of an individual. These mechanisms mainly consist of epigenetic machineries, metabolic pathways, circadian rhythms, and diet-responsive effectors.

J Cell Mol Immunol, 2023, Volume 2, Issue 1, p27-30 | DOI: 10.46439/immunol.2.020

Commentary Open Access

Inhibiting hypoxia-inducible factor in T cells strengthens effector-memory function in CD8+ T cells

Farooq Riaz, Ping Wei, Fan Pan

In a recent attempt to elucidate the role of HIF1α in modulating the fate of T cells, we have demonstrated that the targeted deletion of HIF1α, specifically in T cells, enhances the inflammatory capabilities and memory phenotype of CD8+ T cells.

J Cell Mol Immunol, 2023, Volume 2, Issue 1, p31-34 | DOI: 10.46439/immunol.2.021

Research Article Open Access

Multiple RNA-binding proteins associated with long interspersed element-1 encoded ORF1p are targeted by the autoimmune response in systemic lupus erythematosus

Kennedy C. Ukadike, Alyssa N. Colyer, Bhargavi Duvvuri, Anders A. Bengtsson, Martin S. Taylor, John LaCava, Christian Lood, Tomas Mustelin

Systemic lupus erythematosus (SLE) is a relatively common autoimmune disease characterized by the presence of autoantibodies against nucleic acids and proteins that associate with them, such as the ORF1p protein encoded by the long interspersed element-1 (LINE-1 or L1). Because well-known lupus autoantigens like RO60 associate with ORF1p in macromolecular assemblies, together with many other RNA-binding proteins, we tested whether these other proteins are also recognized by IgG autoantibodies in SLE patients.

J Cell Mol Immunol, 2023, Volume 2, Issue 1, p35-44 | DOI: 10.46439/immunol.2.022

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