Journal of Clinical and Experimental Hematology

In recent years, various types of synthetic cannabinoids have become widely distributed and are causing social and health problems in most parts of the world. Synthetic cannabinoids are currently the largest group of new psychoactive substances. Those that have been subjected to legal control are replaced by newer controlled and uncontrolled substances.

Maintenance of neuroendocrine-immune homeostasis is tightly regulated by the active involvement of neural, endocrine and immune mediators. As age progresses, this bidirectional regulation losses its robustness due to the influence of several factors especially, gonadal hormones. Among the hormones, estrogen has gained significant attention due to its diverse effects as a potent modulator on the cellular and systemic level which influences both physiological and psychological functions.

Background: Maternal hemorrhage represents the most prevalent complication and primary cause of mortality during childbirth. Extensive studies have elucidated noteworthy correlations between ABO blood type and cardiovascular disease risk in both genders. Notably, individuals with blood type O exhibit a substantial variation in the formation of the platelet plug on vascular lesions, accompanied by a reduction in von Willebrand factor.

Streptococcus pyogenes infection continues to be a worldwide public health problem causing various diseases in humans, including impetigo and oropharyngeal infections that are responsible for the development of rheumatic fever (RF), a multi-organ inflammatory disorder, Rheumatic heart disease (RHD) is its major sequel that leads to heart valves lesions, clinically classified as regurgitation and/or stenosis.

Myeloproliferative neoplasms (MPN) are occasionally associated with autoimmune manifestations. The prevalence of positive direct antiglobulin test (DAT) in patients with JAK2V617F mutation is not yet known.

The significance of KIR like natural killer cell receptors in autoimmune disorders was published by us in the year 2020 in a reputed journal “Clinical Immunology”. In this issue we have discussed the complex nature of autoimmune diseases revealing a multi-factorial etiology that involves a combination of genetic and environmental factors

In the past decade, a tremendous progress has been made in developing T cell engaging bi-specific antibodies (BsAbs) targeting CD19 to treat B cell malignancies. The T cell engaging bi-specific molecule binds to CD3 on a T cell and a tumor-associated antigen (TAA) on a target cell and redirects the T cell to a specific target cell bypassing the MHC restriction mechanism, leading to the formation of immune synapse between the T cell and target cell and target cell lysis.

In the previous several years there has been much progress in developing more accurate thixo- lasto- visco-plastic rheological models that can be used to mechanically characterize human blood. In theory as the thixo-elasto-visco-plastic (TEVP) model accuracy and predictive capability improves, the parameterization, as well as insights and parametric correlations will also improve. 

Anemia is a condition that causes decline of erythrocytes concentration in circulation or hemoglobin in the blood and a concomitant impairment of oxygen transportation. The World Health Organization (WHO) defined as hemoglobin (Hgb)<12 g/dL in adult non-pregnant women, Hgb <11g/dL in pregnant females, Hgb <13g/dL in adult men, Hgb <11g/dl in children whose age is 6-59 months, Hgb <11.5 g/dl in children whose age is 5-11years, Hgb<12 g/dl for children whose age is 12-14 years and Hgb <13 g/dL in newborns.

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extranodal Non Hodgkin Lymphoma. Combined modality treatment with high-dose methotrexate (HD-MTX) followed by whole brain radiotherapy (WBRT) has been a commonly used treatment approach.

Activated phosphoinositide 3-kinase delta syndrome (APDS) is a rare syndrome of immune dysregulation that is inherited in an autosomal dominant fashion and results in varying severity of the clinical phenotype. APDS is a result of a gain-of-function mutation in the gene PIK3CD, which codes for a catalytic subunit of the PI3K-Delta kinase.

Rapid, accurate, and comprehensive assessment of hemostasis is of great importance in many clinical settings. Key hematological indices routinely assessed in bleeding patients or patients at risk for bleeding are coagulation function, platelets, and hematocrit. Current clotting assays are limited to a partial analysis of hemostasis (individual faceted clotting elements), thereby providing an incomplete assessment of bleeding and thrombotic risks and status.

The superior mesenteric artery syndrome is an uncommon entity included in the spectrum of vascular syndromes. The low presentation, variety of unspecific symptoms, and shortage of bibliography presents a challenging diagnosis for both clinicians and radiologists. Our aim is to present a 63 years-old male patient with pancreatitis history and repeated symptoms. 

Individuals with spinal cord injury (SCI) have a significantly increased risk for cognitive impairment that is associated with cerebrovascular remodeling and endothelial dysfunction. The sub-acute stage following high thoracic SCI is characterized by increased fibrosis and stiffness of cerebral arteries. However, a more prolonged duration after SCI exacerbates cerebrovascular injury by damaging endothelium.

Malan syndrome (Sotos Syndrome 2, OMIM 614753) is a rare autosomal dominant overgrowth disorder caused by either chromosome 19p13.2/19p13.13 microdeletion or Nuclear Factor 1 X-Type (NFIX) gene haploinsufficiency. Symptoms typically appear in infancy and include dysmorphic features, seizures, and behavioral issues; however, the degree of immune system involvement is not clear. Herein, we are reporting a case of Malan syndrome who presented to the immunology clinic with recurrent bacterial infections, including three episodes of pneumonia confirmed by chest X-ray.

This study presents a comprehensive exploration into the shared molecular mechanisms linking psoriasis and major depressive disorder (MDD), two conditions that are increasingly recognized as having potential comorbidities. It offers new insights into the immune and genetic pathways that may contribute to both disorders, emphasizing the potential of CD19 as a biomarker and therapeutic target through the PPARγ/β-catenin/Wnt3a signaling pathway.

Systemic lupus erythematosus (SLE) is a relatively common autoimmune disease characterized by the presence of autoantibodies against nucleic acids and proteins that associate with them, such as the ORF1p protein encoded by the long interspersed element-1 (LINE-1 or L1). Because well-known lupus autoantigens like RO60 associate with ORF1p in macromolecular assemblies, together with many other RNA-binding proteins, we tested whether these other proteins are also recognized by IgG autoantibodies in SLE patients. By ELISAs and immunoblots, we detected autoantibodies in the serum of SLE patients recognizing proteins encoded by LARP7, MOV10, ZCCHC3, MEPCE, YARS2, RPL18A, RPL27A, and H2BC17 (p<0.05), but not CORO1B, DDX6, PABPC1, and PABPC4, and were mostly absent or low in healthy controls.

Objectives: Physical function impairment can cause great stress to older adults. The purpose of the study is to investigate the association between self-reported and directly-observed physical function on perceived stress among U.S. Chinese older adults. 

Millions of couples around the world experience emotional, social, and financial hurdles due to infertility. Selenium, a nutrient that has recently gained significant attention, is often overlooked in discussions about reproductive health.

Multicentric reticulohistiocytosis (MRH) is a rare granulomatous disease manifesting by the subsequent appearance of erosive aggressive polyarthritis and typical skin papulonodular lesions. It can also affect internal organs such as the lungs, hearts in addition to rare cases of mesenteric lymphadenopathy and urogenital lesions.