Journal of Clinical and Experimental Hematology

As the soft tissue- air interface is virtually impenetrable to ultrasound, its utility for evaluating lung pathologies was historically thought to be unfeasible [1]. However, the observation of different artifacts and novel research into their interpretations has helped transform this dogma and develop lung ultrasound as a valuable diagnostic tool in pulmonary diseases.

A man in his 90s presented to clinic with a conjunctival lesion on the right eye noticed two months prior. The patient denied pain but endorsed worsening blurry vision. The patient’s past medical history was significant for skin cancer on the right ear removed 3 years ago, and a history of ocular surface lesion removal on one eye approximately 20 years ago that was negative for any neoplasia. Slit lamp photograph revealed a gelatinous and opalescent lesion suspicious for ocular surface squamous neoplasia (OSSN) and the high-resolution optical coherence tomography (HROCT) cut (arrow)

Introduction: Traumatic intracranial pseudoaneurysms (TICAs) and penetrating cerebrovascular injuries (PCVI) complicate gunshot wounds to the head (GSWH) and other forms of penetrating traumatic brain injury (pTBI). Recent developments in neuroimaging have allowed early detection of these lesions in the minutes and hours following the initial injury. CT angiography (CTA) and digitally subtracted angiography (DSA) have different sensitivity, periprocedural risks, and logistical limitations. Growing evidence is defining their role in clinical practice.

Thoracic Outlet Syndrome (TOS) has a complex history that has led to misunderstanding and confusion from physicians. We review the history of TOS to better understand where this confusion comes from.

Sports and exercise medicine (SEM) has undergone significant transformations over the past few decades, mirroring advancements in science, technology, and a growing understanding of the critical role that physical activity plays in overall health and wellbeing. As a multidisciplinary field, SEM encompasses the prevention, diagnosis, treatment, and rehabilitation of injuries and medical conditions related to sports and exercise. It also includes the promotion of physical activity for health benefits. This editorial explores the current trends, challenges, and future directions in SEM, emphasizing the importance of innovation and integration.

Mesenchymal stem cells (MSCs) are widely used in regenerative medicine. They can be isolated from different adult tissues. However, the regenerative potential of MSCs obtained from various sources and from different age donors may significantly differ.

HELLP syndrome (hemolysis, elevated liver blood tests and low platelets) is a serious complication in pregnancy characterized by hemolysis, elevated liver enzymes and low platelet count occurring in 0.2 to 0.6% of all pregnancies and in 10–20% of cases with severe preeclampsia

While opioids remain our most potent analgesics in the management of pain, the many potential harms of prescription opioids have become increasingly clear. Despite the analgesic benefits for people with acute and chronic pain [1], opioid therapy (especially long-term opioid treatment) can result in significant problems such as opioid misuse, the development of opioid use disorder, and overdose. Some authors report that up to 20-30% of patients in primary and tertiary care settings who are maintained on long-term opioid therapy misuse opioids (i.e., use them in a manner other than how the opioids are prescribed) [2,3]. Misuse of opioids can cause or exacerbate additional health problems in people with chronic pain [1,4], and in fact, roughly 10% of patients prescribed long-term opioid therapy may develop an opioid use disorder (OUD), although prevalence varies between studies depending on differences in methodology and operational definitions [3]. 

Stem cell therapy for the treatment of cerebral palsy is a rapidly expanding area of research that has been identified as a high priority by consumers. There are several types and sources of stem cell therapies under investigation. Stem cell treatments proposed for cerebral palsy are believed to provide benefit via some or all of the following mechanisms including immunomodulation, paracrine signaling and supporting endogenous reparative processes.

Sanfilippo Syndrome Type-B remains an untreatable childhood neurodegenerative disease with great burden for both patient and caregiver. Very few clinical trials have been undertaken to treat the disease, and none of these have yet yielded clinically obtainable products for patients. Caused by a simple enzyme function deficiency, Sanfilippo Syndrome Type-B has been considered a great prospect for gene-therapy interventions.

Opsoclonus myoclonus syndrome (OMS), also known as Kinsbourne Syndrome, is a rare disorder affecting the central nervous system. It presents clinically with ataxia, diffuse or focal muscle spasms, and rapid, irregular eye movements.

Streptococcus pyogenes infection continues to be a worldwide public health problem causing various diseases in humans, including impetigo and oropharyngeal infections that are responsible for the development of rheumatic fever (RF), a multi-organ inflammatory disorder, Rheumatic heart disease (RHD) is its major sequel that leads to heart valves lesions, clinically classified as regurgitation and/or stenosis.

Wolf-Hirschhorn Syndrome (WHS, OMIM 194190) is a rare congenital malformation syndrome caused by a partial deletion of the short arm (p) of chromosome 4. It is characterized by “Greek warrior helmet” facies, central nervous system disorders including seizures and structural defects, and intrauterine growth restriction, among numerous other systemic anomalies.

Human immunodeficiency virus type 1 (HIV-1) continues to pose a significant global health challenge despite advances in combined antiretroviral therapy (cART), which has transformed HIV-1 infection from a fatal disease to a manageable chronic condition. However, cART is not curative, and its long-term use is associated with challenges such as pill burden, drug toxicities, and the emergence of drug-resistant viral strains.

The rising prevalence of cirrhosis has become a significant global health concern. Cirrhosis is a leading cause of morbidity and mortality worldwide, contributing to a substantial burden on healthcare systems and economies.

The identification of calcified sclero-choroidal choristomas (CaSCCs) in patients with mosaic RASopathies introduces a new dimension to understanding ocular manifestations in these genetic disorders.

Cystinosis is a rare autosomal recessive lysosomal storage disorder, characterised by the intra-lysosomal accumulation of cystine. Cystinosis results from a defect in the CTNS protein, a lysosomal transport protein for cystine. There are three subtypes of cystinosis: infantile nephropathic cystinosis, juvenile nephropathic cystinosis and ocular non-nephropathic cystinosis.

According to the International Organization of Physical Therapy in Mental Health (IOPTMH), physiotherapy in mental health is a recognized specialty of physical therapy, with a subgroup representing physiotherapists from around the world before the World Confederation of Physical Therapy (WCPT). It is implemented in different settings, in health, psychiatry and psychosomatic medicine.

In the nightmare of the coronavirus pandemic that is spreading around the world, parents could take comfort in one thing - early reports that the virus mysteriously spares children, even though this often leads to critical illness in older people. An article published in the Journal “Pediatrics”, based on 2,143 young people in China, provides the most comprehensive evidence of the spread of the virus among children, and there is bad news and good news [1].

Alzheimer’s disease (AD) is a global health crisis currently afflicting ~6 million Americans (and ~40 million people worldwide). By the middle of the century, these numbers will stagger by ~16 million Americans (and ~152 million people worldwide) suffering from AD, if breakthrough disease-modifying treatments are not discovered.