Journal of Clinical and Experimental Hematology

Commentary Open Access

Taking BAFF-R targeting CAR T-cells on the road

Martha E. Gadd, Hong Qin

Chimeric antigen receptor (CAR) T cells were first clinically tested in trials against metastatic solid tumors without therapeutic benefit; however, these efforts established the necessary domains that are required for a functional CAR T-cell. With the characterization of cells within the immune system, the expression of CD19 was found to dictate B cell lineage that remains present on normal and malignant B cells.

Commentary Open Access

Commentary: Three-dimensional transvaginal ultrasound diagnosis of interstitial ectopic pregnancy in a unicornuate uterus: A case report

Yanhua Dong, Hezhou Li, Runwei Liang

Unicornuate uterus represents a congenital uterine anomaly, with an incidence of approximately 0.1%-0.4%. The discourse surrounding the administration of interstitial pregnancy persists as a subject of contention. This uncommon malady is on the rise in terms of frequency, encompassing approximately 2%-6.8% of all instances of ectopic gestations and comprising 2%-4% of tubal ectopic pregnancies.

Commentary Open Access

Commentary on “Ultrasmall polyvinylpyrrolidone-modified iridium nanoparticles with antioxidant and anti-inflammatory activity for acute pancreatitis alleviation”

Wenzhang Jin, Xiang Su

Acute pancreatitis (AP) can lead to severe body damage, including a systemic inflammatory response and multiorgan failure, and current therapies rely heavily on symptomatic treatment and supportive care, with a lack of targeted therapeutic strategies for specific pathologic processes.

Research Article Open Access

Gender disparity in the reticulocyte count of HIV-positive patients on HAART management in Ilorin

Pius O. Omosigho, Ayodele O. Ilesanmi, Lydia N. Asonye

Reticulocytes are immature red blood cells (RBCs). In the process of erythropoiesis (red blood cell formation), reticulocytes develop and mature in the bone marrow and then circulate for about a day in the bloodstream before developing into mature red blood cells.

Commentary Open Access

The tip of the reproductive screening iceberg: ‘Every mother and every fetus matters’

R Douglas Wilson, MD MSC

The basic maternity preventive, diagnostic, and treatment services support for the ‘beginning of life’ are routinely offered, as outlined in the ‘Every Mother and Every Fetus Matters’ manuscript. The routine maternity screening tests are important and necessary but if the fetal screening or imaging procedures identifies fetal pathology, the routine maternal screening tests are only the tip of the screening and diagnostic iceberg. 

Commentary Open Access

An overview of clinical, molecular, and therapeutic approaches to Niemann-Pick disease

Kamran Hosseini

In animal cells (especially humans), there is an enzyme called acid sphingomyelinase (ASM) (EC 3.1.4.12) which can break the large molecule of sphingomyelin and convert it into smaller structures of ceramide and phosphorylcholine.

Commentary Open Access

How effective are antioxidants without fetal hemoglobin in tackling oxidative stress in sickle cell disease?

Yusuf Ishaya Dogonzo, Christopher Chimaobi Onyeabor

Sickle cell disorder (SCD) remains a disease of public interest, accounting for a significant number of deaths, especially in low and middle-income countries in Africa. Despite years of intensive studies, its cure remains a subject of ongoing investigation.

Commentary Open Access

Acquired cutis laxa: Hematological insights and therapeutic implications in a paraneoplastic context

Joe Khodeir, Paul Ohanian

Acquired cutis laxa (ACL) is a rare dermatological disorder characterized by loose, sagging, and inelastic skin due to the progressive degradation of elastic fibers within the dermis. Unlike the congenital form of cutis laxa, which is present from birth and often linked to genetic mutations, ACL typically develops later in life and can be associated with various underlying conditions.

Commentary Open Access

Commentary on “Beyond infantile hemangiomas: A glimpse into overlapping rare syndromes emphasizing the vigilant screening for PHACE and LUMBAR syndromes”

Marleine E. Negrón, Karla J. Martinez, Luis R. Berríos

Due to their complex etiology and pathogenesis, hemangioma-related syndromes, such as LUMBAR and PHACE, present diagnostic and therapeutic challenges. Despite advances, standardized diagnostic criteria, screening protocols, and treatment options still need to be developed. We report a rare case of a 1-month-old patient with nonspecific symptoms, including failure to thrive and poor feeding, associated with lumbosacral ulcers.

Commentary Open Access

Artificial intelligence in hematology: A critical perspective

Kavya Singh, Anuradha Singh

The increasing prevalence of drug-resistant pathogens has highlighted the need for innovative approaches in drug discovery, including drug re-purposing. Artificial intelligence (AI) has emerged as a transformative tool in this endeavor, with the potential to revolutionize not only drug re-purposing for infectious diseases but also the field of hematology.

Commentary Open Access

Cardiac toxicities of Bruton's tyrosine kinase inhibitors: The risk of pericarditis and cardiac tamponade

Thomas Erblich

Nearly a decade since the introduction of first-generation Bruton’s tyrosine kinase (BTK) inhibitors in the treatment of chronic lymphocytic leukaemia (CLL), their use has expanded with the second-generation agents zanubrutinib and acalabrutinib. These agents show high efficacy particularly in patients with TP53 mutations or del(17p).

Research Article Open Access

Assessment of quality of life in people living with hemophilia: A case study of Yaoundé Hemophilia Treatment Centre, Cameroon

Aurélien Chendjou Kamela, Annick Mintya Ndoumba, Verdiane Mabopda, Kevin Romuald Nana Noumtchue, Dora Mbanya, Claude Tayou Tagny

Hemophilia is a rare, sex-linked congenital bleeding disorder caused by a mutation in the genes responsible for production of coagulation factor VIII (hemophilia A) or factor IX (hemophilia B), resulting in the inability of blood to clot. According to Stonbraker et al., hemophilia occurs in approximately 1 in 10,000 births, with hemophilia A being more common, representing 80-85% of cases.

Commentary Open Access

Methionine adenosyltransferase 2A (MAT2A) inhibitors as single agents or in combination strategy for cancer therapy 

Yi Kuang, Zhiyong Yu, Feng Zhou

Methionine adenosyltransferase 2A (MAT2A), one of the rate-limiting enzymes in the methionine cycle, primarily catalyzes methionine into S-adenosylmethionine (SAM). SAM is the global methyl-donor for transmethylation and biosynthesis reactions, which protein arginine N-methyltransferase 5 (PRMT5) utilizes for symmetric dimethylarginine (SDMA) posttranslational modifications.