Commentary Open Access

Hepatic stellate cells as RSPO3-Wnt/β- catenin hubs governing liver zonation and regenerative capacity

Aihua Zhang , Chao Wang , Chunsheng Lin , Qiang Yang , Shi Qiu , Sifan Guo , Ying Cai , Zhibo Wang

The liver emerges as an ultimate metabolic nexus—a polyfunctional organ that simultaneously performs biochemical detoxification, macromolecular processing, and systemic nutrient governance. While hepatic stellate cells (HSCs) were historically confined to their fibrogenic identity, their broader homeostatic orchestration remained enigmatic. RSPO3 as a linchpin in hepatocyte dynamics, with targeted pharmacological modulation enhancing hepatic lobular repatterning, regenerative capacity, and metabolic optimization.