Articles

The recently published study “Religious practices and quality of life in palliative care: insights from Tanzania” has brought to the forefront the indispensable role of spiritual practices in supporting patients with advanced cancer. The overwhelming demand for prayer and faith-based engagement demonstrates how religion provides meaning, resilience, and comfort in the face of terminal illness.

Psychosomatic disorders are highly prevalent in modern healthcare systems, reflecting the intricate interplay between psychological distress, sociocultural stressors, and physical symptomatology. Migration represents one of the major psychosocial stressors of the 21^st century, yet its effects on mental health are highly heterogeneous and influenced by intersecting factors such as gender, socioeconomic position, and discrimination experiences.

Yao syndrome (YAOS) is a NOD2-associated autoinflammatory disease marked by periodic fevers, dermatitis, polyarthritis, distal extremity swelling, and nearly universal gastrointestinal symptoms. A recent study was the first to comprehensively assess the gastrointestinal symptoms and manifestations of YAOS, finding that most testing is normal, without gastrointestinal mucosal inflammation, and many patients have constipation and rectal evacuation disorders.

Diabetic Myonecrosis is a rare, under-diagnosed complication of long-standing diabetes mellitus. The condition often mimics several other conditions which results in delay in diagnosis and treatment. It usually affects muscles of the lower limbs especially thighs, presenting with acute onset pain and swelling. 

Introduction: Hereditary breast cancer is most commonly caused by inherited mutations in the BRCA1 or BRCA2 genes, which significantly increase the risk of breast and ovarian cancers. 

With the recently published review in Cellular Signaling, we highlight the importance of Methyltransferase-like (METTL) family-mediated N6-methyladenosine (m6A) modification in head and neck cancer (HNC) progression, providing a theoretical foundation for their potential use as therapeutic targets.

This commentary discusses our recent findings that, contrary to the β-cell rest hypothesis, early short-term insulin administration in a mouse model of marginal β-cell deficiency paradoxically worsened glycemic control and induced adverse α-cell-mediated islet remodeling. Early insulin intervention is hypothesized to preserve β-cell function; however, its utility in marginal β-cell deficiency is not well-established. 

Pemphigus comprises a rare but potentially life-threatening group of autoimmune bullous dermatoses that primarily affect the skin and mucous membranes. Histopathologically, it is characterized by the presence of intraepidermal acantholysis and deposition of IgG autoantibodies against desmosomal cadherins, notably desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3), leading to compromised intercellular adhesion among keratinocytes.

Liver diseases, such as cirrhosis and hepatocellular carcinoma (HCC), significantly contribute to global mortality rates, with increasing cases associated with hepatitis viruses, alcohol-related liver disease, and non-alcoholic fatty liver disease (NAFLD). Conventional treatments often encounter limitations due to side effects, high costs, and incomplete efficacy, highlighting the need for alternative therapeutic strategies.

CAR-T cell therapy revolutionized the treatment of patients with relapsed or refractory B-cell hematologic malignancies, substantially altering their prognosis. Alongside its remarkable efficacy, however, this approach is frequently accompanied by treatment-related toxicities. 

Prevalence of common autoimmune diseases such as multiple sclerosis (MS), type 1 diabetes, rheumatoid arthritis, and inflammatory bowel disease and allergies such as food allergies or eczema affect approximately 20% of the human population.

Hopelessness, helplessness and haplessness are concepts that are conceptually related to one another. In empirical studies, it is found that these concepts are associated with psychopathological traits, including suicidal ideation, as etiological or sustaining factors. It is suggested that studying these thoughts in clients is important for both prevention and treatment studies.

The consequence of pesticides on human health is a significant area of research. Different types of pesticides can cause various side effects on our body systems, including our organs and glands. One notable effect is on the gonads, which are the glands responsible for producing male and female sex hormones. The effects can be severe, leading to infertility in men and women, as well as other health issues.

Health disparities have become a major concern for global public health, disproportionately affecting minority and underserved populations throughout the United States (U.S.). Hispanics make up the fastest-growing minority group in the U.S., and they often experience significant health disparities when it comes to chronic diseases such as cancer, cardiovascular disease, and diabetes. These disparities are likely driven by a confluence of socioeconomic disadvantages, structural inequities, environmental exposures, and cultural barriers.

Thyroid cancer (TC) encompasses several pathological types, notably papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), medullary thyroid cancer (MTC), and anaplastic thyroid carcinoma (ATC). While PTC accounts for the most common type, ATC, despite representing only 1–2% of all TC cases, is recognized as the most lethal and treatment-resistant endocrine malignancy. Despite sharing a common cellular origin, these two subtypes differ markedly in their clinical trajectories, response to therapy, and immune profiles. 

Cephalospinal fluid (CSF) dynamics (secretion and absorption) rate is considered a primary disturbance in the CSF dynamics. CSF reabsorption is a key part of ventriculomegaly, and to a lesser extent other anatomical features of CNS such as elasticity, brain water content, glial cell ratio, tissue atrophy, cranial suture status, age, weight, height, and sex. 

Fasciola hepatica is a liver trematode with worldwide animal distribution, most commonly seen in sheep- and cattle-raising areas. The flukes are leak-like, flat worms, measuring 2–4 cm. The number of reports of Fasciola hepatica has increased significantly recently, and several geographical areas have been described as endemic for the disease in humans, with prevalence and incidence ranging from low to very high.

This paper analyzes a misdiagnosed case of invasive pulmonary aspergillosis (IPA) presenting with left upper limb pain as an atypical symptom, exploring cognitive blind spots in clinical diagnosis, limitations in imaging and laboratory examinations, and therapeutic challenges. It emphasizes the importance of multidisciplinary collaboration in complex cases.

Neuromyelitis optica spectrum disorder (NMOSD) with aquaporin-4 immunoglobulin G positivity (AQP4-IgG) is a severe autoimmune disease of the central nervous system (CNS) characterized by inflammatory attacks targeting the optic nerves and spinal cord. Pathologically, these attacks are driven by the binding of pathogenic AQP4-IgG to astrocytes, which triggers a potent, complement-dependent cytotoxicity.

Cancer therapy related cardiac dysfunction (CTRCD) poses a significant challenge to the treatment of cancer patients receiving cardiotoxic chemotherapeutic regimen like anthracyclines and human epidermal growth factor receptor 2 (HER2) inhibitors like trastuzumab. This systematic review evaluated the efficacy and safety of conventional heart failure medications—angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and beta-blockers (BBs)—in preventing CTRCD in adults undergoing such therapies.