Articles

Pleckstrin Homology-like Domain family B member 3 (PHLDB3) is a member of the PHLDB protein family characterized by the presence of two central coiled-coil (CC) domains and a C-terminal pleckstrin homology (PH) domain. This family includes PHLDB1 with 1377 amino acids (AAs), PHLDB2 with 1253 AAs, and PHLDB3 with 640 AAs. Although more studies have been reported on PHLDB1 and PHLDB2, our lab has made some progress in investigating PHLDB3. 

Triple-negative breast cancer (TNBC) remains a major clinical challenge due to the absence of validated molecular targets and limited durability of current immunotherapies. Survivin, a tumor-associated inhibitor of apoptosis, is highly expressed in TNBC and contributes to tumor progression, therapeutic resistance, and poor clinical outcomes, making it an attractive but immunologically challenging target. In this commentary, we discuss recent preclinical findings describing a rationally engineered dendritic cell targeted anti-Survivin vaccine, DCSurvivin-LTB, designed to overcome immune tolerance to this self-antigen. 

Cancer is increasingly recognized as a systems-level disease in which genetic alterations interact with metabolic, epigenetic, transcriptional, post-transcriptional, and microenvironmental regulatory networks.

Nursing education historically relied on hospital-based apprenticeship models and physician-led diploma programs. While early milestones initiated the push toward professionalization, the acute demands of World War II fundamentally altered the structural trajectory of the field.

Drug-induced cardiotoxicity remains a predominant driver of compound attrition across non-clinical drug development and post-market safety withdrawals. While the Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative shifted regulatory screening from an isolated focus on hERG inhibition toward integrated human-relevant platforms, conventional safety pharmacology still contends with the limitations of cardiomyocyte heterogeneity and univariate analytical thresholds. 

To explore the metabolome of normal and malignant breast tissues and try to discriminate BCa disease in a cohort of African American women, biospecimens (n=48) were analyzed by untargeted metabolomics using 1H nuclear magnetic resonance (NMR) spectroscopy. Breast specimens were characterized as control or malignant.

Access to treatment for disorders related to the abuse of psychoactive substances is a global public health priority. In 2021, the Centre for Addiction Support and Care in Abidjan (CASA) was created to address the issue of care provision through an integrated approach combining opioid substitution therapy. The aim of the study was to determine the epidemiological profile and describe the treatment outcomes of drug users seeking care at CASA.

We present a case of an Allurion gastric balloon complicated by significant symptoms requiring prompt decompression. As the patient declined endoscopic intervention under general anesthesia, percutaneous ultrasound-guided catheter aspiration was performed to deflate the balloon.

Alport syndrome is a genetically heterogeneous disorder with X-linked, autosomal dominant, autosomal recessive, and digenic inheritance patterns. The X-linked form, most commonly due to COL4A5 mutations, is the most prevalent and typically results in more severe disease in males, while heterozygous females are usually less severely affected. 

Background: The outcome of interventional pain procedures may be influenced not only by technical and patient-related factors but also by contextual factors arising from the physician–patient interaction. Patient expectations and physician communication have been associated with pain outcomes in experimental and clinical settings, but their relevance in CT-guided interventional pain treatment remains insufficiently understood.

Sub-Saharan Africa (SSA) accounted for nearly 70% of global maternal deaths in 2023. As mortality from direct obstetric causes declines, cardiovascular disease is emerging as an increasingly important yet underrecognized contributor to maternal morbidity and mortality. The regional burden includes rheumatic and congenital heart disease, peripartum cardiomyopathy, hypertensive disorders of pregnancy, and HIV-associated cardiovascular disease. 

The “Choosing Wisely” recommendations issued by the Society of Surgical Oncology in 2016 recommend against routine use of Sentinel Lymph Node Biopsy (SLNBx) in select patients 70 years and older. Despite this guideline, SLNBx rates are consistently above 80% across the U.S in those eligible for omission. 

To evaluate the effectiveness of a standardized saphenous vein care program compared with unstandardized care on pain levels, lower extremity edema, surgical site infection, skin complications, and compliance with home care in patients after coronary artery bypass grafting (CABG).

Pediatric congenital and acquired heart diseases contribute substantially to morbidity and mortality in low- and middle-income countries (LMICs), including Ethiopia, where access to pediatric cardiac services remains limited. Constrained infrastructure and financing, workforce shortages, fragmented referral systems, and limited longitudinal follow-up delay diagnosis and treatment and worsen inequities. Comorbid infection and malnutrition further complicate care delivery and outcomes.

Psychotherapy is increasingly practiced across disciplines, with clinicians from different professions bringing distinct scopes of practice, theoretical orientations, approaches to assessment, and ways of knowing to their psychotherapy practice. Clinical supervision, however, has often remained situated within disciplinary or theoretical silos. This commentary introduces the Stemmed Diamond Model of Clinical Supervision, a conceptual framework designed to support integrative and transdisciplinary psychotherapy supervision. 

Knowledge of ABO and RhD blood type prevalence within a population is essential for blood transfusion services to maintain an adequate, appropriately distributed supply, particularly for rarer types such as RhD negative blood.

Prenatal depression is common and may be associated with adverse prenatal and postpartum outcomes when untreated. However, treatment rates among pregnant women remain relatively low. As Medicaid is the largest public insurer during pregnancy in the United States, it is important to understand whether Medicaid beneficiaries receive appropriate depression treatment during pregnancy and the characteristics of women engaging in treatment.

A psychiatrist receives the following message from the family of a patient after her death:  “A lot of people were surprised by her steep and rapid decline. My goal had always been to keep A home as long as I could. I am happy that I did keep her home, and the kids and I were with her when she passed at age 75! I want to thank you for all you did to access and help A in the clinical study. I believe that drug and study added a few years to her life so we could enjoy one another. I will miss her like crazy”.

Risk stratification for gastrointestinal stromal tumor (GIST) depends on postoperative mitotic index (MI), a histologic marker unavailable before surgery to guide neoadjuvant therapy and operative strategy. In 2020, Ren et al.

Early-onset colorectal cancer (EOCRC) is increasing worldwide and represents a biologically and clinically heterogeneous disease that requires precision approaches extending beyond conventional single-gene biomarkers. Recent analyses of receptor tyrosine kinase-RAS (RTK-RAS) pathway alterations demonstrate that their clinical significance is strongly dependent on age at diagnosis, ancestry, and treatment exposure. In particular, RTK-RAS alterations have been associated with unfavorable survival in untreated early-onset non-Hispanic White colorectal cancer, while an opposite association has been observed in FOLFOX-treated late-onset disease.