Journal of Cellular and Molecular Immunology

Epigenetics is the study of heritable modifications to gene expression, such as DNA methylation, histone modifications, and RNA modifications, that do not alter the nucleotide sequence of the corresponding gene. Recently, RNA modification has emerged as a novel research focus. We have detected over 170 different RNA modifications,  such as N6-methyladenosine (m6A), N7-methylguanosine (m7G), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N3-methylcytosine (m3C), and pseudouridine (ψ).These modifications are important for biological processes like RNA metabolism and post-transcriptional regulation. 

In “Family Strategies to Support Siblings of Pediatric Hematopoietic Stem Cell Transplant Patients”, we described the 10 strategies used by families to support siblings. One of the strategies was sharing information. Interestingly, only about one third of the parents (Fathers (7/21, 33.3%), and Mothers (8/20, 40%)) indicated that they shared information with the patient about the transplant decision while over half of the children (10/17, 59%) reported that information was shared with them. 

For more than a decade, the nuclear factor kappa-B (NFκB) family and their signaling pathways have proved crucial to the immune system's functioning. According to research, this factor is implicated in almost every immune system event, including immune cell development and function, activation, and pathogen-activated cell death. A considerable body of evidence suggests the idea that, in addition to being a possible transcription factor, it plays a very significant role in the establishment of inflammation-associated immunological responses in host cells. Inflammation is a cascade of events that involve vasodilation and immune cell migration to the site of infection in order to defend the host. 

As the field of immunology continues to unravel the complexities of immune responses and their intersection with therapeutic interventions, the emergence of innovative drug delivery systems has sparked new avenues of exploration. The original research on FericipXT-coated PEGylated rutile TiO₂ nanoparticles (NPs) in drug delivery has not only illuminated the realm of pharmaceutical science but also beckons the attention of immunologists, offering profound insights into the immunological implications of nanoparticle-based drug delivery systems.

Scales are data collection tools that can measure characteristics such as knowledge, emotion, interest, perception, attitude, belief, disposition, risk, quality of life and behavior. The scale development process includes determining the theoretical foundations, creating the items, pilot study, validity and reliability analysis, and final implementation. In the stage of determining the theoretical foundations, the definitions of the construct that the scale wants to measure in the literature are examined and a conceptual framework is created. At the stage of creating the items, expert opinions are taken and their suitability in terms of language and meaning is evaluated.

Enteric fever is a major public health concern in developing countries. Enteric fever can result from Salmonella typhi and Salmonella paratyphi infections after consuming contaminated food or water. The increase in widespread drug resistance is severely limiting treatment options for this serious disease. This case report covers a 23 year old patient history who got lab acquired infection of Salmonella paratyphi A infection. Initially, he experienced symptoms of fever, and irritability, which progressed to severe loose motions and high-grade fever.

Zhang et al. provide an extensive review titled "Vitamin K2 in Health and Disease: A Clinical Perspective", expanding on their earlier research. Vitamin K (VK) is a crucial cofactor for the γ-carboxylation of glutamic acid residues in VK-dependent proteins (VKDPs). The human body contains at least 17 different VKDPs, also known as Gla proteins, which can be classified into hepatic and extra-hepatic VKDPs based on their location of synthesis within the body. Hepatic VKDPs encompass coagulation factors II, VII, IX, and X, along with anticoagulant proteins C, S, and Z.

Dendritic cells (DC) present antigens for an immune reaction. Subtypes of DC such as plasmocytic (pDC), monocytoid (mDC), immature (imDC), classical (cDC), follicular (fDC), and interdigitating (intDC) and Langerhans cells (LHC) either aggravate or limit an immune reaction. Not much is known about the role of LHC and DCs in respiratory bronchiolitis-interstitial lung disease (RB-ILD), and desquamative interstitial pneumonia (DIP) and Langerhans cell histiocytosis (LHCH).