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Journal of Cellular and Molecular Immunology
ISSN: 2833-1141
Sarah C. Glover
Professor
University of Mississippi Medical Center, USA
Immunotherapy as a treatment to confront the ongoing opioid epidemic- A review
Journal of Cellular and Molecular Immunology is an international, single-blinded, peer reviewed, rapid publication journal from the house of ProBiologists. The journal covers a wide range of interdisciplinary subject areas which includes vaccination methodology, antigen-antibody interactions, MHC complex, autoimmune reactions, immunological disorders and therapeutics.
Identification and validation of N7-methylguanosine-associated gene NCBP1 as prognostic and Prognostic immune-associated biomarkers in breast cancer patients
Epigenetics is the study of heritable modifications to gene expression, such as DNA methylation, histone modifications, and RNA modifications, that do not alter the nucleotide sequence of the corresponding gene. Recently, RNA modification has emerged as a novel research focus. We have detected over 170 different RNA modifications, such as N6-methyladenosine (m6A), N7-methylguanosine (m7G), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N3-methylcytosine (m3C), and pseudouridine (ψ).These modifications are important for biological processes like RNA metabolism and post-transcriptional regulation.
The importance of assessing a family’s information-sharing strategy in pediatrics
In “Family Strategies to Support Siblings of Pediatric Hematopoietic Stem Cell Transplant Patients”, we described the 10 strategies used by families to support siblings. One of the strategies was sharing information. Interestingly, only about one third of the parents (Fathers (7/21, 33.3%), and Mothers (8/20, 40%)) indicated that they shared information with the patient about the transplant decision while over half of the children (10/17, 59%) reported that information was shared with them.
Nuclear factor kappa-B: The El Dorado of inflammatory immune response
For more than a decade, the nuclear factor kappa-B (NFκB) family and their signaling pathways have proved crucial to the immune system's functioning. According to research, this factor is implicated in almost every immune system event, including immune cell development and function, activation, and pathogen-activated cell death. A considerable body of evidence suggests the idea that, in addition to being a possible transcription factor, it plays a very significant role in the establishment of inflammation-associated immunological responses in host cells. Inflammation is a cascade of events that involve vasodilation and immune cell migration to the site of infection in order to defend the host.
Nanoparticle-based drug delivery systems: Unveiling the immunological implications
As the field of immunology continues to unravel the complexities of immune responses and their intersection with therapeutic interventions, the emergence of innovative drug delivery systems has sparked new avenues of exploration. The original research on FericipXT-coated PEGylated rutile TiO2 nanoparticles (NPs) in drug delivery has not only illuminated the realm of pharmaceutical science but also beckons the attention of immunologists, offering profound insights into the immunological implications of nanoparticle-based drug delivery systems.
Scale adaptation and redevelopment: A review on validity and reliability
Scales are data collection tools that can measure characteristics such as knowledge, emotion, interest, perception, attitude, belief, disposition, risk, quality of life and behavior. The scale development process includes determining the theoretical foundations, creating the items, pilot study, validity and reliability analysis, and final implementation. In the stage of determining the theoretical foundations, the definitions of the construct that the scale wants to measure in the literature are examined and a conceptual framework is created. At the stage of creating the items, expert opinions are taken and their suitability in terms of language and meaning is evaluated.
Case report: Typhoid fever due to laboratory acquired Salmonella paratyphi confirmed through antibiotic sensitivity testing
Enteric fever is a major public health concern in developing countries. Enteric fever can result from Salmonella typhi and Salmonella paratyphi infections after consuming contaminated food or water. The increase in widespread drug resistance is severely limiting treatment options for this serious disease. This case report covers a 23 year old patient history who got lab acquired infection of Salmonella paratyphi A infection. Initially, he experienced symptoms of fever, and irritability, which progressed to severe loose motions and high-grade fever.
Unveiling the health implications of vitamin K2 deficiency
Zhang et al. provide an extensive review titled "Vitamin K2 in Health and Disease: A Clinical Perspective", expanding on their earlier research. Vitamin K (VK) is a crucial cofactor for the γ-carboxylation of glutamic acid residues in VK-dependent proteins (VKDPs). The human body contains at least 17 different VKDPs, also known as Gla proteins, which can be classified into hepatic and extra-hepatic VKDPs based on their location of synthesis within the body. Hepatic VKDPs encompass coagulation factors II, VII, IX, and X, along with anticoagulant proteins C, S, and Z.
Are dendritic cells in smoking induced lung diseases functionally impaired?
Dendritic cells (DC) present antigens for an immune reaction. Subtypes of DC such as plasmocytic (pDC), monocytoid (mDC), immature (imDC), classical (cDC), follicular (fDC), and interdigitating (intDC) and Langerhans cells (LHC) either aggravate or limit an immune reaction. Not much is known about the role of LHC and DCs in respiratory bronchiolitis-interstitial lung disease (RB-ILD), and desquamative interstitial pneumonia (DIP) and Langerhans cell histiocytosis (LHCH).
Immunotherapy as a treatment to confront the ongoing opioid epidemic- A review
Substance use disorders continue to be major medical and social problems worldwide. The use of opiate has grown substantially over the past three decades reaching the dimensions of a global epidemic. Current drug treatments have many limitations: long treatment times, dependency on treatment medications, relapses after treatment, high costs of treatment, and non-adherence by affected persons. Most of the available drug treatments for opiate addiction belong to the opioid family. Some worry that the availability of the drugs may simply cause substituting one opioid medication for another.
Immunotherapy as a treatment to confront the ongoing opioid epidemic- A review
Substance use disorders continue to be major medical and social problems worldwide. The use of opiate has grown substantially over the past three decades reaching the dimensions of a global epidemic. Current drug treatments have many limitations: long treatment times, dependency on treatment medications, relapses after treatment, high costs of treatment, and non-adherence by affected persons. Most of the available drug treatments for opiate addiction belong to the opioid family. Some worry that the availability of the drugs may simply cause substituting one opioid medication for another.