Journal of Cellular and Molecular Immunology

Commentary Open Access

Update on glomerulonephritis: How to classify and how to treat

Martin Klaus , Matteo Abinti , Marc Patricio Liébana , Hans-Joachim Anders

The term glomerulonephritis (GN) describes immune-mediated disorders of the kidney’s filtration units (the glomeruli). Current classifications are based on histopathological lesion patterns. However, different underlying conditions can lead to similar tissue injury and lesions but the respective therapy depends on the underlying disease.

Commentary Open Access

The role of EMMPRIN in Marfan syndrome-related thoracic aortic aneurysms: A commentary

Shannon Parness , Panagiotis Tasoudis

The authors of this study investigated the pathogenesis of thoracic aortic aneurysms (TAAs) in patients with Marfan Syndrome (MFS). The prevailing hypothesis attributes TAAs to the aberrant remodeling of the extracellular matrix, driven by matrix metalloproteinases (MMPs), which progressively degrade the vessel wall.

Commentary Open Access

Granulomatosis with polyangiitis triggered by SARS-CoV-2: Diagnostic challenges and clinical implications

Daniele Romanello , Sara Rotunno

Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is an autoimmune vasculitis characterized by necrotizing inflammation of small- and medium-sized vessels, primarily affecting the lungs and kidneys.

Commentary Open Access

Insights into placental cell senescence in pregnancy, preeclampsia, and peripartum cardiomyopathy

Claire Castro , Kathryn J Gray , Jason D Roh

Cardiovascular disease (CVD) is a leading cause of maternal mortality worldwide. The molecular mechanisms underlying de novo CVD in pregnancy are not fully understood, which has limited targeted therapeutic development.

Review Article Open Access

The ontogeny of IgE forming cells

Dominick L. Auci

The origin and fate of IgE forming cells has commanded attention for more than 50 years largely because they drive allergic diseases that plague a third of the world’s most economically privileged populations. Ontogeny studies began in the early1980s with the expressed intent of locating these cells so that IgE production might be turned off at the source, at the level of the IgE forming B cell. They continue to the present day. The technological revolution at the turn of the last century neatly divides efforts. From the outset, IgE seemed unlike other isotypes. IgE forming cells did not appear to clone in germinal centers like other B cells, but to arise rapidly and transiently within gut after stimulation.

Review Article Open Access

Host’s innate immune response to SARS-CoV-2 infection—Current understanding and trends

Nitin Saksena

The COVID-19 pandemic, which began in 2019 due to SARS-CoV-2, remains a global health crisis, especially as new variants emerge that could trigger widespread outbreaks again. While various aspects of SARS-CoV-2 infection warrant attention, the antiviral innate immune response is a crucial area of focus.

Commentary Open Access

Aging shapes baseline immunity in sterilehoused female hAPOE mouse genotypes

Fernandez F , Reyes-Reyes E , Chinnasamy D , Trial M , Rodgers KE

The Apolipoprotein E ε4 allele (APOE4) is a major risk factor in the development of late-onset Alzheimer’s Disease (LOAD; AD) and has been associated with altered immunological responses, particularly under inflammatory challenge. Whether APOE genotype shapes baseline peripheral immunity across aging remains unclear.