Journal of Cellular and Molecular Immunology

Letter to the Editor Open Access

The dichotomous role of A. muciniphila in CRC: from probiotic to postbiotic

Diana Diba Ara , Adel Noursina , Fatemeh Abbasi

We recently engaged with the systematic review by Soheilipour et al.[1], concludes that Akkermansia muciniphila primarily acts as a pathobiont in colorectal cancer (CRC) by exacerbating tumor progression. While the authors provide a comprehensive analysis of the bacterium's pathobiont potential (particularly its propensity to exacerbate colitis-associated tumorigenesis by degrading mucins in inflamed environments) we wish to underscore a pivotal therapeutic evolution: the transition from live probiotics to targeted postbiotics (defined as non-viable bacterial products or metabolic byproducts that confer a health benefit to the host).

J Cell Mol Immunol, 2026, Volume 5, Issue 1, p5-6 | DOI: 10.46439/immunol.5.041

Commentary Open Access

Zika virus antibody patterns passed from mother to baby: insights from epitope-level mapping

Anderson Pereira Soares , Paolo Marinho de Andrade Zanotto

This commentary contextualizes the findings reported in Soares et al. (Scientific Reports, 2025), which investigated maternal–newborn humoral immune interactions during Zika virus (ZIKV) infection using epitope-level mapping. In that study, paired sera from mother–newborn dyads were analyzed using SPOT-synthesis peptide arrays spanning the ZIKV proteome, revealing a high qualitative overlap of antibody targets between mothers and neonates, alongside marked quantitative differences in signal intensity. 

J Cell Mol Immunol, 2026, Volume 5, Issue 1, p1-4 | DOI: 10.46439/immunol.5.040