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Journal of Biomed Research
ISSN: 2693-5910


Giuseppe Lanza
Senior University Researcher
University of Catania, Italy
Non-invasive optical brain pulse monitoring: Experience from the first 195 patients
CRISPR-Cas systems: A revolution in genome editing and its diverse applications
Modeling of psychological time cognition with Human Language based Consciousness model
Journal of Biomed Research is an international scientific peer reviewed journal having a broad scope of incorporating both clinical and basic science topics of medicine in health and diseases. The journal publishes original research articles, reviews, editorials, case reports, short communications, commentary etc. in the field of medicine and its subspecialties.
Tsetse fly management and trypanosomiasis control strategies in Ethiopia
Animal trypanosomiasis, caused by protozoan parasites of the genus Trypanosoma, is a major constraint to livestock production in sub-Saharan Africa, including Ethiopia. The disease, primarily transmitted by tsetse flies (Glossina spp.), leads to anemia, weight loss, reduced milk and meat production, infertility, and mortality in affected animals, causing significant socio-economic losses.
Extracts from Nicotiana glauca as a therapeutic strategy against rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a type of soft tissue sarcoma, which commonly appears in the head, neck, genitourinary region and extremities. RMS is believed to originate due to alterations in the growth and activity of immature precursor muscle cells, preventing their differentiation into skeletal muscle cells and thus acquiring malignant potential.
Molecular network regulation and precision therapy frontiers in osteoarthritis: from ferroptosis to autophagy metabolic reprogramming
Osteoarthritis (OA), the most prevalent degenerative joint disease, involves intricate molecular interactions across joint tissues. This review highlights advancements in understanding OA pathogenesis, focusing on the ferroptosis-autophagy axis and the therapeutic potential of Coenzyme Q10 (CoQ10).
Bovine mastitis: causopathology, diagnosis, treatment, and patho-pathogenesis
Mastitis is an inflammatory disease of the bovine mammary gland caused by bacterial, viral, fungal, or parasitic infections, with pathogens primarily entering through the teat canal. Once established, they proliferate and evade host immunity, triggering complex immunological cascades mediated by bacterial toxins, proteins, and immunomodulators, which can result in increased somatic cell counts, vascular permeability, fibrosis, and systemic toxemia in severe cases.
Successful management of odontogenic maxillary sinusitis and Subclinical oroantral communication post dental implant using combined endoscopic and Caldwell Luc approach: a case report
Objective: To successfully manage odontogenic maxillary sinusitis & subclinical oroantral communication post dental implant, using combined endoscopic & Caldwell Luc approach without removing dental implant.
The living bridge - applications of physiological principles in biomedicine
In the ever-evolving landscape of biomedicine, physiology continues to act as the quiet architect behind many transformative advances. While molecular biology often captures attention and technology impresses with precision, physiology offers the deeper narrative of how life actually unfolds within the human body.
Reimagining psychiatric classification in the age of Big Data
Mental health diagnosis is undergoing a quiet but decisive transformation, one that reflects both the strengths and the limits of the systems that have guided psychiatry for more than half a century. For decades, structured diagnostic manuals provided a shared language for clinicians, researchers, and institutions, allowing a field once marked by inconsistency to establish a degree of coherence and legitimacy.
Non-invasive optical brain pulse monitoring: Experience from the first 195 patients
Continuous, non-invasive optical brain pulse monitoring (OBPM; Cyban Pty. Ltd., Melbourne, Australia) represents a significant advancement in the field of neurological monitoring. OBP monitoring uses red and infrared light sources to capture cardiac and respiratory waves from brain pulse waveforms, which reflect changes in both brain oxygen levels and brain movement.
Digital workflow for high-risk, low-volume procedure simulation
For thousands of years, simulations have been used by doctors for training before performing high-risk procedures on patients. Due to changes in healthcare and academic environments, as well as the introduction of new technologies, we have seen an increase in the use of simulation for education and competency assessment.
Human and Earth evolution through CO2: Perspective for climate crisis
Although human civilization has developed through genomic evolution, including its fingernail-functional cooperation, the daily lives of humans have resulted in a significant amount of carbon dioxide (CO2) being released into the atmosphere since the Industrial Revolution, which started almost 200 years ago. Recently, climate change has been documented to have spread globally.
A longing for flawless awakening from general anesthesia
Anesthetic recovery can be a critical period since neurocognitive problems such as agitation and delirium are often seen during the early recovery phase. We recently demonstrated that an α2-adrenergic agonist dexmedetomidine-induced unconsciousness and accompanying brain dynamics changes were completely and instantly reversed by the α2-adrenergic antagonist in the nonhuman primate model.
Syndrome similar to Familial Hypocalciuric Hypercalcemia (FHH) produced in mice deleted of the gene encoding transient receptor potential canonical channel 1 (TRPC1)
We recently found that global deletion of TRPC1 produces phenotypes similar to FHH. These TRPC1 null mice have mildly elevated serum Ca in both fasted and unfasted conditions from 3.5 through 21.5 months of age, and inappropriately elevated parathyroid hormone (PTH) levels. They also have hypocalciuria, similar to FHH patients.
Cell therapies for neonatal encephalopathy: On the question of dose, route of administration, timing, and single versus multiple doses
The optimal range of cell dose, route of administration, and timing for the treatement of neonatal encephalopathy are not known. However, it is not practical to systematically interrogate all combinations of these variables in animal models to define the optimal cell therapy protocol. Despite this limitation, a number of trends are present in the literature that should be considered when designing future clinical and preclinical trials.
CRISPR-Cas systems: A revolution in genome editing and its diverse applications
The clustered regularly interspaced short palindromic repeats (CRISPR) Cas (CRISPR6 associated protein) system is an advanced adaptive immune system found in prokaryotes. First discovered in1987, CRISPR Cas has revolutionized genetic research in the past two decades. CRISPR-Cas9 the most widespread system enables precise gene editing by creating double strand breaks.
A longing for flawless awakening from general anesthesia
Anesthetic recovery can be a critical period since neurocognitive problems such as agitation and delirium are often seen during the early recovery phase. We recently demonstrated that an α2-adrenergic agonist dexmedetomidine-induced unconsciousness and accompanying brain dynamics changes were completely and instantly reversed by the α2-adrenergic antagonist in the nonhuman primate model.
Syndrome similar to Familial Hypocalciuric Hypercalcemia (FHH) produced in mice deleted of the gene encoding transient receptor potential canonical channel 1 (TRPC1)
We recently found that global deletion of TRPC1 produces phenotypes similar to FHH. These TRPC1 null mice have mildly elevated serum Ca in both fasted and unfasted conditions from 3.5 through 21.5 months of age, and inappropriately elevated parathyroid hormone (PTH) levels. They also have hypocalciuria, similar to FHH patients.
Commentary: SARS-CoV-2 new variants: Characteristic features and impact on the efficacy of different vaccines
A recent article published by Abbas et al. in the Journal of Biomedicine and Pharmacotherapy systematically revealed about the vaccines developed against the recent pandemic agents SARS-CoV-2 and its variants [1]. The authors insightfully provided an overview on the distinct features of the SARS-CoV-2 new variants, the associated mortality rate, hospitalization, re-infection and finally the efficacy of different vaccines.
Attaining highest honors: A study proposal for the medical student’s honors bar expectancy and values changes within medical education
Expectancy-Value theory was originally proposed by John William Atkinson in the 1950s and 60s as an attempt to understand different behaviors of students including persistence, decision making when given multiple opportunities to choose from, and the effort of striving for success.
Modeling of psychological time cognition with Human Language based Consciousness model
This paper interprets subjective psychological time in a model of consciousness called the HLbC model proposed by the authors. Time has an objective physical time and a subjective psychological time. Subjective psychological time is thought to vary in its flow depending on the individual and the situation. For this explanation, this paper introduces surreal numbers into the perception of subjective psychological time.
Digital workflow for high-risk, low-volume procedure simulation
For thousands of years, simulations have been used by doctors for training before performing high-risk procedures on patients. Due to changes in healthcare and academic environments, as well as the introduction of new technologies, we have seen an increase in the use of simulation for education and competency assessment.
Human and Earth evolution through CO2: Perspective for climate crisis
Although human civilization has developed through genomic evolution, including its fingernail-functional cooperation, the daily lives of humans have resulted in a significant amount of carbon dioxide (CO2) being released into the atmosphere since the Industrial Revolution, which started almost 200 years ago. Recently, climate change has been documented to have spread globally.
Blending into the crowd: electrophysiological evidence of gestalt perception of a human dyad: extended discussion and theoretical viewpoint
In this commentary, we provide further discussion and interpretation of a recent article entitled “Blending into the Crowd: Electrophysiological Evidence of Gestalt Perception of a Human Dyad”, published one year ago by the first author of the present commentary. Firstly, drawing a parallel between the experiment described in the above article and another closely comparable experimental study, we propose that the neural integration process evidenced when seeing two human shapes close in space is a marker of the categorization of a stimulus as a group of humans (two here) represented as an entity per se.
Cell therapies for neonatal encephalopathy: On the question of dose, route of administration, timing, and single versus multiple doses
The optimal range of cell dose, route of administration, and timing for the treatement of neonatal encephalopathy are not known. However, it is not practical to systematically interrogate all combinations of these variables in animal models to define the optimal cell therapy protocol. Despite this limitation, a number of trends are present in the literature that should be considered when designing future clinical and preclinical trials.
Commentary: SARS-CoV-2 new variants: Characteristic features and impact on the efficacy of different vaccines
A recent article published by Abbas et al. in the Journal of Biomedicine and Pharmacotherapy systematically revealed about the vaccines developed against the recent pandemic agents SARS-CoV-2 and its variants [1]. The authors insightfully provided an overview on the distinct features of the SARS-CoV-2 new variants, the associated mortality rate, hospitalization, re-infection and finally the efficacy of different vaccines.