Journal of Biomed Research

Commentary Open Access

Syndrome similar to Familial Hypocalciuric Hypercalcemia (FHH) produced in mice deleted of the gene encoding transient receptor potential canonical channel 1 (TRPC1)

Bonnie Eby, Alexander Ku Lau, Meghan Pantalia, Usman Khan, Kai Lau

We recently found that global deletion of TRPC1 produces phenotypes similar to FHH. These TRPC1 null mice have mildly elevated serum Ca in both fasted and unfasted conditions from 3.5 through 21.5 months of age, and inappropriately elevated parathyroid hormone (PTH) levels. They also have hypocalciuria, similar to FHH patients.

Commentary Open Access

A longing for flawless awakening from general anesthesia

Yumiko Ishizawa, Jesus J. Ballesteros

Anesthetic recovery can be a critical period since neurocognitive problems such as agitation and delirium are often seen during the early recovery phase. We recently demonstrated that an α2-adrenergic agonist dexmedetomidine-induced unconsciousness and accompanying brain dynamics changes were completely and instantly reversed by the α2-adrenergic antagonist in the nonhuman primate model.

Review Article Open Access

Attaining highest honors: A study proposal for the medical student’s honors bar expectancy and values changes within medical education

Cheney Elizabeth Huls, Rachel Elizabeth Daum, Zachary Isaac Merhavy, Thomas Chandy Varkey

Expectancy-Value theory was originally proposed by John William Atkinson in the 1950s and 60s as an attempt to understand different behaviors of students including persistence, decision making when given multiple opportunities to choose from, and the effort of striving for success.

Commentary Open Access

Commentary: SARS-CoV-2 new variants: Characteristic features and impact on the efficacy of different vaccines

Jiyun Zhou, Abbas Khan, Dong-Qing Wei

A recent article published by Abbas et al. in the Journal of Biomedicine and Pharmacotherapy systematically revealed about the vaccines developed against the recent pandemic agents SARS-CoV-2 and its variants [1]. The authors insightfully provided an overview on the distinct features of the SARS-CoV-2 new variants, the associated mortality rate, hospitalization, re-infection and finally the efficacy of different vaccines.

Mini Review Open Access

CRISPR-Cas systems: A revolution in genome editing and its diverse applications

Joseph Lin, Jun Yang

The clustered regularly interspaced short palindromic repeats (CRISPR) Cas (CRISPR6 associated protein) system is an advanced adaptive immune system found in prokaryotes. First discovered in1987, CRISPR Cas has revolutionized genetic research in the past two decades. CRISPR-Cas9 the most widespread system enables precise gene editing by creating double strand breaks.