Commentary Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.46439/biomedres.3.016
Syndrome similar to Familial Hypocalciuric Hypercalcemia (FHH) produced in mice deleted of the gene encoding transient receptor potential canonical channel 1 (TRPC1)
Bonnie Eby1, Alexander Ku Lau1, Meghan Pantalia1, Usman Khan1, Kai Lau1,*
- 1Section of Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK and Medical Service, Veterans Administration (VA) Hospital, Oklahoma City, OK, USA
Corresponding Author
Kai Lau, Kai-Lau@ouhsc.edu
Received Date: February 08, 2022
Accepted Date: February 17, 2022
Eby B, Lau AK, Pantalia M, Khan U, Lau K. Syndrome similar to Familial Hypocalciuric Hypercalcemia (FHH) produced in mice deleted of the gene encoding transient receptor potential canonical channel 1 (TRPC1). J Biomed Res. 2022;3(1):1-2.
Copyright: © 2022 Eby B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Syndrome similar to Familial Hypocalciuric Hypercalcemia (FHH) produced in mice deleted of the gene encoding transient receptor potential canonical channel 1 (TRPC1)
We recently found that global deletion of TRPC1 produces phenotypes similar to FHH. These TRPC1 null mice have mildly elevated serum Ca in both fasted and unfasted conditions from 3.5 through 21.5 months of age, and inappropriately elevated parathyroid hormone (PTH) levels. They also have hypocalciuria, similar to FHH patients.