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Journal of Biomed Research
ISSN: 2693-5910
2025
Volume 6, Issue 1, p1-115
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Non-invasive optical brain pulse monitoring: Experience from the first 195 patients
Elliot J. Teo, Sigrid Petautschnig, Finula I Isik, Barry Dixon
Continuous, non-invasive optical brain pulse monitoring (OBPM; Cyban Pty. Ltd., Melbourne, Australia) represents a significant advancement in the field of neurological monitoring. OBP monitoring uses red and infrared light sources to capture cardiac and respiratory waves from brain pulse waveforms, which reflect changes in both brain oxygen levels and brain movement.
J Biomed Res, 2025, Volume 6, Issue 1, p1-10 | DOI: 10.46439/biomedres.6.055
Blinding uveitis induced by secukinumab: A case-based review
Mahjoubi Yasmine Salem, Aouinti Imen, Dahmani Israam, Zgolli Fatma, Charfi Ons, El Aidli Sihem
Secukinumab, a human monoclonal antibody targeting interleukin-17A (IL-17A), is widely used for treating immunoinflammatory disorders. While effective, drug-induced uveitis (DIU) is a rare but serious adverse effect associated with biologic medications like TNF-α inhibitors and more recently, IL-17 inhibitors such as secukinumab. We present a case of posterior uveitis in a 42-year-old male with AS who developed ocular symptoms two years after starting secukinumab.
J Biomed Res, 2025, Volume 6, Issue 1, p11-16 | DOI: 10.46439/biomedres.6.056
Role of cellular, acellular and matrix-like products (CAMPs) in wound bed preparation in diabetic foot
Shubham Vijaykumar, Ravi Kumar Chittoria, Rashmi V Kumar
Diabetic foot ulcers account for 70-80% of all ulcer cases, with this proportion rising to 21–27% in developing countries. The associated mortality rate ranges from 3.75% to 58.8%.
J Biomed Res, 2025, Volume 6, Issue 1, p17-19 | DOI: 10.46439/biomedres.6.057
Clinical insights and research needs in atezolizumab induced neurotoxicity
Mahjoubi Yasmine Salem
In recent years, immune checkpoint inhibitors (ICIs) have transformed the scope of cancer treatment. Atezolizumab, is a humanized monoclonal antibody that specifically targets programmed death-ligand 1 (PD-L1) to block its interaction with PD-1 and B7-1 receptors, thereby reinstating T cell response.
J Biomed Res, 2025, Volume 6, Issue 1, p20-25 | DOI: 10.46439/biomedres.6.058
The pathogenetic roles of arachidonate 5-lipoxygenase, xanthine oxidase and hyaluronidase in inflammatory diseases: A review
Sooriya Arachchige Sachini Jayawardana, Jayanetti Koralalage Ramani Radhika Samarasekera, Gardhi Hettiarachchige Chamari Madhu Hettiarachchi, Mahavidanage Jaanaki Gooneratne
Inflammation is a complex biological process essential for protecting the body from harmful stimuli. However, dysregulated or chronic inflammation can contribute to the pathogenesis of various diseases, including asthma, rheumatoid arthritis, and gout. Pro-inflammatory enzymes, such as arachidonate 5-lipoxygenase (A5-LOX), xanthine oxidase, and hyaluronidase, play key roles in the initiation, progression, and resolution of inflammation.
J Biomed Res, 2025, Volume 6, Issue 1, p26-31 | DOI: 10.46439/biomedres.6.060
Skin necrosis following dobutamine extravasation
Mouna DALDOUL, Charfi Ons, Mahjoubi Yasmine Salem, Ahmed ZAIEM, Aouinti Imen, Sihem AL AIDLI
Dobutamine is a synthetic catecholamine with activity on both alpha-1 and beta-2 adrenoceptors. It is used intravenously as an inotropic agent for short term treatment of heart failure. Dobutamine side effects involve usually cardiovascular system. Cutaneous side effects such as inflammation in the administration site following accidental extravasation could occur. Skin necrosis from intravenous soft tissue infiltration is a rare but serious complication of intravenous therapy. Herein we report a rare case of a local skin necrosis in dobutamine infusion site.
J Biomed Res, 2025, Volume 6, Issue 1, p32-34 | DOI: 10.46439/biomedres.6.059
Interaction effects of FTO polymorphisms on post-surgery weight, and post-BMI after bariatric surgery
Elva Perez-Luque, Steven Daza-Hernández, Nicté Figueroa-Vega, Mónica I. Cardona-Alvarado, Norberto Muñoz-Montes, Claudia Martinez-Cordero
Obesity is associated with increased morbidity and mortality and is a risk factor for cardiovascular disease. Therefore, preventing and treating obesity has become a major public health goal. Bariatric surgery is considered the intervention most effective for patients with severe obesity (BMI ≥40 kg/m2 or ≥35 kg/m2) with comorbidities and to maintain weight loss and glycemic control in the long-term. In addition, improvement or long-term remission of comorbidities such as T2D, hypertension, and dyslipidemia after bariatric surgery has been reported.
J Biomed Res, 2025, Volume 6, Issue 1, p40-44 | DOI: 10.46439/biomedres.6.062
Half-time hydration and re-warm-up strategies for football players
Khawaja Mohammad Mowahid Haider, Khwaja Husnain Haider
We have read the commentary by Fernandes H (2024) with interest on a mini-review entitled Hydration Strategies for Elite Soccer Players. Given the popularity of the game globally and the busy tournament schedules without a break for the soccer players, their fitness remains a primary concern for the players and their coaches alike. Hence, elite soccer performance is crucial and depends on physiological readiness, technical skills, and tactical execution.
J Biomed Res, 2025, Volume 6, Issue 1, p64-65 | DOI: 10.46439/biomedres.6.065
Knowledge, attitude and practice of life style modification in the management of hypertension
Khan Md Shahariar Zaman, Sabrina Shafiq, Md Saiful Islam, Rubaiyat-E-Mortaz, Susmita Debnath, Rokshana Begum, Khandoker Abdur Rahim, Mesbah Uddin Ahmed
Hypertension remains as one of the most important public health challenges worldwide because of the associated morbidity, mortality, and the cost to the society. Despite the availability of safe and effective antihypertensive medications and the existence of clear treatment guidelines, hypertension is still inadequately controlled in a large proportion of patients worldwide. Unawareness of lifestyle modifications, and failure to apply these were one of the identified patient-related barriers to blood pressure control.
J Biomed Res, 2025, Volume 6, Issue 1, p66-71 | DOI: 10.46439/biomedres.6.066
Prevalence of Equine Strongyloidiasis and associated risk factors in Guder, Ethiopia
Zerihun Getie Wassie, Abraham Belete Temesgen
Equines, which include horses, donkeys, mules, and zebras, are large hoofed mammals characterized by long legs, strong hooves, and a diet primarily composed of grasses. These animals play an important role in ecosystems and have been closely connected to human societies throughout history.
J Biomed Res, 2025, Volume 6, Issue 1, p72-77 | DOI: 10.46439/biomedres.6.067
Risk factors of stroke: A cross cut survey study on the basis of social class
Jasim Uddin, Tahmina Jahan Tama
Stroke is the second leading cause of death worldwide and the leading cause of long-term disability. A worldwide study based on vital record and data imputation shows that per year 15 million people faces the event ‘stroke’ which causes 5 million deaths and a further 5 million patients living with permanent cognitive and physical disability.
J Biomed Res, 2025, Volume 6, Issue 1, p78-82 | DOI: 10.46439/biomedres.6.068
Prevalence of gastrointestinal nematodes and associated risk factors of exotic chicken in selected farm of poultry in and around Ambo, Ethiopia
Saleamlak Abebe, Zerihun Getie Wassie, Theobesta Solomon, Abraham Belete Temesgen
Poultry is kept in backyards or commercial production systems in most areas of the world. Compared to a number of other livestock species, fewer social and religious taboos are related to the production, marketing, and consumption of poultry products. For these reasons, poultry products have become one of the most important protein sources for humans throughout the world.
J Biomed Res, 2025, Volume 6, Issue 1, p83-87 | DOI: 10.46439/biomedres.6.069
Commentary on the use of the Taguchi method for electrocoagulation optimization in dairy effluent treatment
Praful N K, Binaya Kumar Pattnaik, Sandipan Das
Dairy industry wastewater, characterized by its high load of organic and inorganic pollutants, continues to pose significant challenges to conventional treatment technologies. Electrocoagulation (EC) has emerged as an effective alternative, but its success depends on the careful optimization of multiple interrelated parameters.
J Biomed Res, 2025, Volume 6, Issue 1, p88-92 | DOI: 10.46439/biomedres.6.070
Overview of Fasciolosis
Tesfaye Mesfin, Abraham Belete Temesgen
Fasciolosis (fascioliasis) is an important parasitic disease of both animals and humans, caused by Fasciola hepatica and F. gigantica. These liver flukes have a complex life cycle involving freshwater snails as intermediate hosts, with infection occurring through ingestion of metacercariae on contaminated vegetation or water.
J Biomed Res, 2025, Volume 6, Issue 1, p93-100
Prevalence of Brucellosis in Saudi Arabia: A meta-analysis
Hasan Nawaz Tahir, Misbah Ahmed, Sarosh Sher Ali, Huma Naim, Imran Zaheer, Khaled Hashim Mahmoud, Mohammed Saleh Al-Dhubaibi, Ramaprabha Prabhakar
Brucellosis is a preventable bacterial illness that is common all over the world and a consistent problem in Saudi Arabia. Understanding the true prevalence of the disease in Saudi Arabia could provide information on how to tackle this health concern.
J Biomed Res, 2025, Volume 6, Issue 1, p101-106
Comparative analysis of initial outcomes: Magnetic sphincter augmentation versus fundoplication in gastroesophageal reflux disease - A systematic review and meta-analysis
Hasan Nawaz Tahir, Shahnawaz Tahir, Sarosh Sher Ali, Maham Aziz Uddin Ahmed, Imran Zaheer, Ahmed Ibrahim AbdElneam, Ahmed Mohammed Al-Dhubaibi, Saad Alsaab, Yousaf Ali
Gastroesophageal reflux disease (GERD) is a long-term digestive condition marked by the backflow of stomach contents into the esophagus. The worldwide combined prevalence of GERD was found to be 13.98%. GERD remains a significant public health problem due to its high global prevalence and potential for severe complications, including esophagitis, strictures, and progression to Barrett’s esophagus and esophageal adenocarcinoma.
J Biomed Res, 2025, Volume 6, Issue 1, p107-115
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