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Journal of Biomed Research

ISSN: 2693-5910

Systematic Review Open Access
Volume 6 | Issue 1 | DOI: https://doi.org/10.46439/biomedres.6.073

Comparative analysis of initial outcomes: Magnetic sphincter augmentation versus fundoplication in gastroesophageal reflux disease - A systematic review and meta-analysis

Hasan Nawaz Tahir1, Shahnawaz Tahir2, Sarosh Sher Ali3,*, Maham Aziz Uddin Ahmed3, Imran Zaheer4, Ahmed Ibrahim AbdElneam5,6, Ahmed Mohammed Al-Dhubaibi7, Saad Alsaab8, Yousaf Ali1
  • 1Community Medicine, College of Medicine, Dawadimi, Shaqra University, KSA
  • 2Gastroenterology, Dow University of Health Sciences, Karachi, Pakistan
  • 3Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
  • 4Department of Pharmacology, College of Medicine, Dawadmi, Shaqra University, KSA
  • 5Department of Clinical Biochemistry, Department of Basic Medical Sciences, College of Medicine, Dwadmi, Shaqra University, KSA
  • 6Molecular Genetics and Enzymology Department, Human Genetics and Genome Research Institute, National Research Center, 33 El Bohouth St. (former El Tahrir St.), Dokki 12622, Cairo, Egypt
  • 7College of Medicine, Marmara University, Istanbul, Turkey
  • 8Department of Medicine, Dean, College of Medicine, Dawadmi, Shaqra University, KSA
+ Affiliations - Affiliations

Corresponding Author

Sarosh Sher Ali, sarosh_sherali@yahoo.com

Received Date: August 25, 2025

Accepted Date: September 12, 2025

Citation:

Tahir HN, Tahir S, Ali SS, Ahmed MAU, Zaheer I, AbdElneam AI, et al. Comparative analysis of initial outcomes: Magnetic sphincter augmentation versus fundoplication in gastroesophageal reflux disease - A systematic review and meta-analysis. J Biomed Res. 2025;6(1):107-115.


Copyright: © 2025 Tahir HN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Abstract

Background: Gastroesophageal reflux disease (GERD) is commonly treated with magnetic sphincter augmentation (MSA) or laparoscopic fundoplication (LF). Both procedures have shown efficacy, but their short-term outcomes, including postoperative symptoms, complications, and quality of life, require further evaluation.

Aims: To compare the short-term outcomes of MSA and LF in GERD treatment, focusing on postoperative symptoms, complications, and quality of life.
Study Design: This systematic review and meta-analysis followed the PRISMA guidelines and was registered with PROSPERO (CRD42024564433).

Methods: We conducted comprehensive search on PubMed, Embase, and Google Scholar for studies comparing MSA and LF in GERD patients. A total of 11 observational cohort studies with 2,156 patients were included. We used fixed or random-effects models for statistical analyses and assessed heterogeneity with the I² index and Cochrane Q-test. Meta-regression analysis was performed to explore potential confounders.

Results: The meta-analysis included 1,332 patients who underwent MSA and 824 who underwent LF. MSA was associated with a significantly lower incidence of gas/bloat symptoms (OR=0.45, 95% CI 0.28–0.72, p=0.001). MSA also showed a higher likelihood of maintaining the ability to vomit (OR=11.4, 95% CI 7.67–16.95, p<0.00001) and belch (OR=6.40, 95% CI 4.23–9.70, p<0.00001) compared to LF. Dysphagia requiring endoscopic dilation was more common in MSA (9.3% vs. 6.52%, OR=2.03, 95% CI 1.19–3.47, p=0.010). Postoperative GERD-Health-Related Quality of Life (HRQL) scores, PPI suspension rates, and reoperation rates were comparable between the two groups.

Conclusion: Both MSA and LF are effective in managing GERD. MSA offers advantages in preserving the ability to belch and vomit, and in reducing gas-bloat symptoms, while postoperative dysphagia may be more frequent. Further randomized controlled trials are necessary to confirm these findings and establish long-term outcomes.

Keywords

Magnetic sphincter augmentation, Fundoplication, Gastroesophageal reflux disease, LINX device, Anti-reflux surgery, Health-related quality of life

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