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Journal of Biomed Research

ISSN: 2693-5910

Commentary Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.46439/biomedres.3.017

A longing for flawless awakening from general anesthesia

Yumiko Ishizawa1,*, Jesus J. Ballesteros1
  • 1Department of Anesthesia, Critical Care & Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA
+ Affiliations - Affiliations

Corresponding Author

Yumiko Ishizawa, yishizawa@mgh.harvard.edu

Received Date: March 28, 2022

Accepted Date: April 07, 2022

Citation:

Ishizawa Y, Ballesteros JJ. A longing for flawless awakening from general anesthesia. J Biomed Res. 2022;3(1):3-5.


Copyright: © 2022 Ishizawa Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Anesthetic recovery can be a critical period since neurocognitive problems such as agitation and delirium are often seen during the early recovery phase. We recently demonstrated that an α2-adrenergic agonist dexmedetomidine-induced unconsciousness and accompanying brain dynamics changes were completely and instantly reversed by the α2-adrenergic antagonist in the nonhuman primate model. Active awakening from general anesthesia using its antagonism can contribute to facilitating post-anesthesia recovery and discharge in various patients, and also potentially prevent the neurocognitive problems that are associated with anesthetic emergence and recovery. The latter possibility should be investigated in the translational animal models.

Keywords

General anesthesia, Anesthetic recovery, Unconsciousness, Consciousness, Neurocognitive function, α2-adrenergic agonist, Dexmedetomidine, 2-adrenergic antagonist

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