Current Rheumatology Research

Background/Purpose: The significance of Dense Fine Speckled (DFS) pattern Anti-nuclear antibodies (ANA) by indirect mmunofluorescence (IIF) is unclear in the existing research. We aimed to investigate associations between positive ANA with DFS pattern and multiple autoimmune and rheumatic conditions.

Background: Generalized lymphadenopathy with fever, pulmonary involvement, and organomegaly in children can be caused by infections, malignancies, or autoimmune disorders, with infections being the most frequent. However, childhood-onset systemic lupus erythematosus (cSLE) can present with similar features, making diagnosis challenging in the absence of classical signs. 

Yao syndrome (YAOS) is a NOD2-associated autoinflammatory disease marked by periodic fevers, dermatitis, polyarthritis, distal extremity swelling, and nearly universal gastrointestinal symptoms. A recent study was the first to comprehensively assess the gastrointestinal symptoms and manifestations of YAOS, finding that most testing is normal, without gastrointestinal mucosal inflammation, and many patients have constipation and rectal evacuation disorders.

Diabetic Myonecrosis is a rare, under-diagnosed complication of long-standing diabetes mellitus. The condition often mimics several other conditions which results in delay in diagnosis and treatment. It usually affects muscles of the lower limbs especially thighs, presenting with acute onset pain and swelling.