Current Rheumatology Research

Original Research Open Access

Dense fine speckled antinuclear antibody patterns: Clinical correlations and implications

Smarika Sapkota, John Crosson, Michael D. Evans, Londyn Robinson, Adam Lord, Benjamin Kofoed, Jerry A. Molitor

Background/Purpose: The significance of Dense Fine Speckled (DFS) pattern Anti-nuclear antibodies (ANA) by indirect mmunofluorescence (IIF) is unclear in the existing research. We aimed to investigate associations between positive ANA with DFS pattern and multiple autoimmune and rheumatic conditions.

Curr Rheumatol Res, 2025, Volume 5, Issue 1, p1-8 | DOI: 10.46439/rheumatology.5.027

Original Research Open Access

The effect of distance to exercise facilities and sociodemographic factors on pain and function among rheumatology patients

Chi Chi Lau, Levi Bonnell, Bradley J. Tompkins, Dawid Czarny, Amanda G. Kennedy

Clinical features are known to influence pain in patients, but demographic characteristics have been less studied. The aim of this cross-sectional study was to evaluate the relationship of distance to exercise facilities and other demographic factors to the pain and function score, RAPID3 (Routine Assessment of Patient Index Data) in a large rheumatology practice. 

Curr Rheumatol Res, p1-7 | DOI:

Commentary Open Access

Yao syndrome (NOD2-associated autoinflammatory disease) and the gastrointestinal tract: Future perspectives and research priorities 

John A. Damianos

Yao syndrome (YAOS) is a NOD2-associated autoinflammatory disease marked by periodic fevers, dermatitis, polyarthritis, distal extremity swelling, and nearly universal gastrointestinal symptoms. A recent study was the first to comprehensively assess the gastrointestinal symptoms and manifestations of YAOS, finding that most testing is normal, without gastrointestinal mucosal inflammation, and many patients have constipation and rectal evacuation disorders.

Curr Rheumatol Res, 2025, Volume 5, Issue 1, p13-16 | DOI: 10.46439/rheumatology.5.029