Journal of Breast Cancer Research

Chemotherapy remains a cornerstone of modern cancer treatment, yet its neurotoxic side effects can pose significant challenges. Peripheral nerve damage and the resulting pain not only affect patients’ quality of life but also contribute to substantial economic burden.

Mammaplasty and mastopexy are surgical procedures designed to reshape and reposition the breast tissue. Reduction mammaplasty primarily aims to decrease breast volume and alleviate symptoms such as back pain and postural discomfort, while mastopexy focuses on elevating and reshaping the breast to restore a more youthful contour.

Breast cancer is the most common cancer in women worldwide, with the highest mortality rates. While breast tumors can have heterogeneous biology, the mutational burden/genomic alterations, etc, are relatively less when compared to other malignancies like pancreatic cancer or glioblastomas, rendering breast tumors comparatively less aggressive.

Background: Modern treatment of breast cancer depends mainly on the expression of biomarkers such as estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). However, a change of receptors was not uncommon during the disease progression. Here we aim to evaluate the impact on clinical outcome from the conversion of receptors in primary tumor and recurrent or metastatic lesions. 

Background: Breast cancer is one of the leading causes of cancer-related mortality among women worldwide. Despite advancements in treatment, therapeutic resistance remains a major challenge, necessitating novel approaches for more effective interventions. 

Estrogen receptor-negative/progesterone receptor-positive (ER-/PR+) breast carcinoma is a rare and controversial subtype that challenges conventional understanding of hormone receptor biology in breast cancer. Traditionally, the expression of progesterone receptors is considered a downstream effect of estrogen receptor activity, making the presence of PR in the absence of ER biologically puzzling. 

Introduction: Healthcare providers (HCPs) and traditional healers (THs) play a pivotal role in the breast cancer treatment pathway and can impact access to timely and effective healthcare. This study aimed to assess the knowledge, attitudes, and practices regarding breast cancer treatment among HCPs and THs in Northern Tanzania. 

Introduction: Hereditary breast cancer is most commonly caused by inherited mutations in the BRCA1 or BRCA2 genes, which significantly increase the risk of breast and ovarian cancers.