Journal of Breast Cancer Research

Review Article Open Access

Harnessing high-concentration (179 mg) capsaicin patches for chemotherapy-induced peripheral neuropathy: Evidence and implications from the QUCIP study

Rainer Sabatowski , Michael Patrick Lux , Tamara Quandel

Chemotherapy remains a cornerstone of modern cancer treatment, yet its neurotoxic side effects can pose significant challenges. Peripheral nerve damage and the resulting pain not only affect patients’ quality of life but also contribute to substantial economic burden.

Commentary Open Access

Histopathological insights and oncological implications in aesthetic breast surgery specimens

Giovanni André Pires Viana , Renata Andréa Pietro Pereira Viana

Mammaplasty and mastopexy are surgical procedures designed to reshape and reposition the breast tissue. Reduction mammaplasty primarily aims to decrease breast volume and alleviate symptoms such as back pain and postural discomfort, while mastopexy focuses on elevating and reshaping the breast to restore a more youthful contour.

Commentary Open Access

Breast cancer prognostic tests: Taking us one step closer to personalized treatment

Shyamili Goutham , Manjiri M Bakre

Breast cancer is the most common cancer in women worldwide, with the highest mortality rates. While breast tumors can have heterogeneous biology, the mutational burden/genomic alterations, etc, are relatively less when compared to other malignancies like pancreatic cancer or glioblastomas, rendering breast tumors comparatively less aggressive.

Original Research Open Access

Receptor discordances between primary and recurrent breast cancer

Tsung-Yen Hsieh , Chun-Yu Liu , Chih-Yi Hsu , Chin-Jung Feng , Jiun-I Lai , Ta-Chung Chao , Yen-Shu Lin , Pei-Ju Lien , Chi-Cheng Huang , Jen-Hwey Chiu , Yi-Fang Tsai , Ling-Ming Tseng

Background: Modern treatment of breast cancer depends mainly on the expression of biomarkers such as estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). However, a change of receptors was not uncommon during the disease progression. Here we aim to evaluate the impact on clinical outcome from the conversion of receptors in primary tumor and recurrent or metastatic lesions. 

Original Research Open Access

Unraveling metabolic signatures in breast cancer: Machine learning for improved therapeutic targeting

Fatemeh Mehdikhani , Parnian Habibi , Sajad Alavimanesh

Background: Breast cancer is one of the leading causes of cancer-related mortality among women worldwide. Despite advancements in treatment, therapeutic resistance remains a major challenge, necessitating novel approaches for more effective interventions. 

Mini Review Open Access

ER negative PR positive breast cancer: Revisiting a rare and controversial molecular subtype 

Smita Chandra

Estrogen receptor-negative/progesterone receptor-positive (ER-/PR+) breast carcinoma is a rare and controversial subtype that challenges conventional understanding of hormone receptor biology in breast cancer. Traditionally, the expression of progesterone receptors is considered a downstream effect of estrogen receptor activity, making the presence of PR in the absence of ER biologically puzzling. 

Original Research Open Access

Knowledge, attitude and practice of breast cancer treatment among health care providers and traditional healers in Tanzania: A crosssectional study

Elizabeth F. Msoka , Kim Madundo , Frank B. Bright , Modesta Mitao , Angela Pallangyo , Bob C. Mulder , Linda Minja , Victor Katiti , Clotilda S. Tarimo , Godfrey Mariki , Baraka Moshi , Innocent Peter Uggh , Yotham Gwanika , Charmaine Blanchard , Maureen Joffe , Eva J. Kantelhardt , Gileard G. Masenga , Brandon A. Knettel , Blandina T. Mmbaga

Introduction: Healthcare providers (HCPs) and traditional healers (THs) play a pivotal role in the breast cancer treatment pathway and can impact access to timely and effective healthcare. This study aimed to assess the knowledge, attitudes, and practices regarding breast cancer treatment among HCPs and THs in Northern Tanzania. 

Original Research Open Access

A rare BRCA1 alternative missense mutation identified in African American women with breast cancer

Desta Beyene , Luisel J. Ricks-Santi , Delisha A. Stewart , Muneer Abbas , Andrea Hayes-Dixon , Ahmed Ali , Olakunle O. Kassim , Robin Williams , Steven Nagel , Babak Shokrani , Robert L. Copeland , Yasmine M. Kanaan

Introduction: Hereditary breast cancer is most commonly caused by inherited mutations in the BRCA1 or BRCA2 genes, which significantly increase the risk of breast and ovarian cancers.