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Review Article Open Access
Volume 5 | Issue 1 | DOI: https://doi.org/10.46439/breastcancer.5.025

Harnessing high-concentration (179 mg) capsaicin patches for chemotherapy-induced peripheral neuropathy: Evidence and implications from the QUCIP study

  • 1Comprehensive Pain Center, Department of Anesthesiology and Intensive Care, Medical Faculty “Carl Gustav Carus”, Technical University, Dresden, Germany
  • 2Department for Gynecology and Obstetrics, St. Louise Women’s Hospital, Paderborn, St. Josefs Women’s Hospital, Salzkotten, St. Vincenz Clinics Salzkotten & Paderborn, Paderborn, Germany
  • 3Grünenthal GmbH, Medical Affairs D-A-CH, Aachen, Germany
+ Affiliations - Affiliations

Corresponding Author

Rainer Sabatowski,

rainer.sabatowski@ukdd.de

Received Date: December 20, 2024

Accepted Date: January 13, 2025

Abstract

Chemotherapy remains a cornerstone of modern cancer treatment, yet its neurotoxic side effects can pose significant challenges. Peripheral nerve damage and the resulting pain not only affect patients’ quality of life but also contribute to substantial economic burden. Despite the medical need, a definitive curative treatment for chemotherapy-induced peripheral neuropathy (CIPN) remains elusive, leaving many patients reliant on analgesics for pain relief. The QUCIP study, a prospective, multi-center observational study spanning 36 weeks, has recently yielded data evaluating the effectiveness of up to three treatments with high-concentration (179 mg) capsaicin patch (HCCP) in 73 female patients with painful CIPN following neoadjuvant/adjuvant breast cancer therapy. In this review, we discuss the results of the QUCIP trial and position its findings within the broader body of evidence on repeated HCCP treatment, highlighting its potential to progressively improve therapeutic outcomes and reduce the burden of CIPN in oncology care.

Keywords

Chemotherapy-induced peripheral neuropathy (CIPN), High-concentration capsaicin patch (HCCP), QUCIP study, Peripheral neuropathic pain, Topical treatment, Progressive response

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