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Archives of Stem Cell and Therapy
ISSN: 2767-343X
Most Read Articles
Molecular signatures of aggressive pediatric liver cancer
Michael E. Johnston , Nikolai Timchenko
Liver masses account for 5 to 6% of pediatric cancer, which includes hepatoblastoma (HBL) along with rare cases of hepatocellular carcinoma (HCC). The most dangerous form of pediatric liver cancer is aggressive HBL, which can be characterized by chemo-resistance and multiple nodules or metastases at diagnosis, all correlating with worse clinical prognosis. Despite intensive studies and a significant improvement in overall outcomes, very little is known about the key molecular pathways which determine the aggressiveness of pediatric liver cancer.
Arch Stem Cell Ther, 2021, Volume 2, Issue 1, p1-4 | DOI: 10.46439/stemcell.2.006
The significance of triple-capsid-mutant AAV8 for treatment of Sanfilippo Syndrome Type B
Frederick Ashby , Coy Heldermon
Sanfilippo Syndrome Type-B remains an untreatable childhood neurodegenerative disease with great burden for both patient and caregiver. Very few clinical trials have been undertaken to treat the disease, and none of these have yet yielded clinically obtainable products for patients. Caused by a simple enzyme function deficiency, Sanfilippo Syndrome Type-B has been considered a great prospect for gene-therapy interventions.
Arch Stem Cell Ther, 2022, Volume 3, Issue 1, p11-17 | DOI: 10.46439/stemcell.3.013
Role of the rapid delayed rectifier K+ current in human induced pluripotent stem cells derived cardiomyocytes
Makarand Deo , Akwasi Akwaboah , Bright Tsevi , Jacqueline A Treat , Jonathan M Cordeiro
The action potential (AP) in cardiac tissue is important for initiating and coordinating contractions in the heart. In addition, the long refractory period minimizes the potential for developing extrasystoles and arrhythmias. The AP is generated by coordinate changes in different ionic currents. In human (or canine) adult ventricular cells, the depolarization phase of the AP is mainly through the influx of Na+ and Ca2+ through specific voltage gated channels.
Arch Stem Cell Ther, 2020, Volume 1, Issue 1, p14-18 | DOI: 10.46439/stemcell.1.003
Post-allogeneic stem cell transplant FLT3-targeted maintenance therapy: updates and considerations for clinical practice
Jonathan Cohen , Richard T. Maziarz
Acute myeloid leukemia (AML) is characterized by multiple molecular and cytogenetic abnormalities, with increasing data to support clinical and prognostic implications to guide clinical decision making. One of the most well described mutations involves fms-like tyrosine kinase 3 (FLT3) that results in a constitutively active tyrosine kinase and is generally associated with poor prognosis involving shorter overall survival and higher rates of relapse.
Arch Stem Cell Ther, 2022, Volume 3, Issue 1, p23-27 | DOI: 10.46439/stemcell.3.015