The epidermal growth factor receptor (EGFR) is a member of the ErbB family. It is involved in biological processes such as cell proliferation, angiogenesis, inhibition of apoptosis, adhesion, metastasis, and is associated with the progression of lung cancer [1-3].

Lung cancer is the leading cause of cancer death among both men and women in the United States. Because lung cancer is genetically heterogeneous, tailored therapy alone or in combination with chemotherapy would increase patient overall survival as compared with the one-size-fits-all chemotherapy. TP53-mutant lung cancer accounts for more than half of all lung cancer cases and is oftentimes more aggressive and resistant to chemotherapy. Directly targeting mutant p53 has not yet been successful, so identification of novel therapy targets and biomarkers in the TP53-mutant lung cancer is urgently needed to increase the overall survival in this subgroup.

In the United States, lung and bronchus cancers are the second most common types of cancer and are responsible for the largest number of deaths from cancer, with African Americans suffering disproportionately from lung and bronchus cancers. This disparity likely results from a complex interplay among social, psycho-social, lifestyle, environmental, health system, and biological determinants of health.

Traditional Chinese Medicine (TCM), the world’s oldest known herbal medicine, has long been used in several Asian countries. Emerging evidence has demonstrated their effectiveness and safety in the treatment of various diseases, ranging from mild flu to severe cancers. A great number of patients have benefited by receiving TCM therapies. However, due to the complex chemical compositions of TCM, which could produce highly complex compound-protein binding interactions, the molecular mechanisms underlying the pharmacological actions of TCM still remain poorly understood. Specifically, it is difficult to identify and isolate the effective constituents from the mixture of many compounds, even the therapeutic targets are known.