Abstract
Sleeve gastrectomy is the most common bariatric surgery worldwide. However, such a surgery caries risk of complications associated with morbidity and mortality. Gastric leak can occur and represents one of the most severe complications following sleeve gastrectomy. Since the two last decades, regenerative medicine has emerged, offering new strategies to face to sleeve gastrectomy complications. Among these, autologous transplantation of material appears to be promising. Indeed, platelet rich plasma-based therapy has gained interest in several fields since it contains many bioactive materials involved in the hemostatic process. Moreover, mesenchymal stem cells-based approaches appear as the gold standard strategy as it takes advantage of stem cells plasticity, renewal and repair of damaged tissue abilities. In this article, we combined plasma rich platelet with mesenchymal stem cells therapy on obese rat models that went under gastric leak following sleeve gastrectomy. The data suggest that this combined therapy appears to be promising since it favors the healing process. Altogether, it suggests that stem cell therapy combined with plasma rich platelet may become a new tool in the treatment of gastric leak following sleeve gastrectomy.
Keywords
Sleeve gastrectomy, Gastric leak, Bariatric surgery, Regenerative medicine, Mesenchymal stem cells, Platelet rich plasma