Multiple sclerosis (MS) is central nervous system (CNS) based disease. It is a chronic inflammatory demyelinating disease [1]. The main causes for MS are genetic and environmental factors. It is a disease of young people (median age of onset is around 28 years) but is lifetime and is often disabling; 50% of patients need a cane to walk 15 years after disease onset; and Worldwide more than 2.5 Million persons are affected.

Participating in physical activity and exercise has significant benefits, including treating, preventing, and reducing risk factors for chronic conditions such as diabetes, hypertension, coronary heart disease, and osteoarthritis. Physical activity can also positively play a role in palliative care among individuals with terminal diseases. 

CNS myelination is a well-known biological phenomenon related to increase in action potential conduction speed and synaptic integration. Demyelination or abnormal myelination has been related to seizures and epilepsy either in patients or animal models. Although its role in fastening action potential propagation has been confirmed, few additional biological functions of CNS myelin has been described.

A close and contemplative look at the published neurology literature makes it clear to the reader that epilepsy research possesses more popularity and occupies a higher position in the plethora of scholarly medical writings. Perhaps the reason behind this is that epilepsy nowadays has become more than just transient seizures that are treated with drugs to put an end to seizure recurrence, but rather it is a disease that permeates all aspects of the patient’s life.