The recent pandemic of SARS-CoV-2 has emerged as a health emergency to develop effective therapeutic strategies for restricting deadly disease, COVID-19. SARS-CoV-2 infects cells by the endocytosis process via receptor-mediated binding and priming by cellular proteases.

The case study describes a rare and maybe fatal consequence of coronary stent infection (CSI), with an emphasis on the rise in occurrence over the last decade [1]. In order to enhance patient outcomes, the authors stress the need for early recognition and proper medical and surgical management. Coronary artery disease (CAD) is a serious global health concern, with an estimated 126 million people worldwide suffering from it. In addition, CAD caused millions of fatalities in 2017 [2].

Streptococcus pyogenes infection continues to be a worldwide public health problem causing various diseases in humans, including impetigo and oropharyngeal infections that are responsible for the development of rheumatic fever (RF), a multi-organ inflammatory disorder, Rheumatic heart disease (RHD) is its major sequel that leads to heart valves lesions, clinically classified as regurgitation and/or stenosis.

The COVID-19 pandemic that emerged in 2020 may affect the peripheral and central auditory system. According to studies in the literature, symptoms affecting the vestibulocochlear system such as sudden hearing loss, tinnitus, and vestibular neuritis are seen in individuals with COVID -19. 

The trigeminal nerve is one of twelve pairs of cranial nerves that attach to the brain. The name “trigeminal” literally means three twins and refers to the fact that the fifth cranial nerve has three major divisions: the ophthalmic (V1), the maxillary (V2), and the mandibular (V3) [1]. The trigeminal nerve is the major sensory nerve of the face and is the nerve of the first branchial arch.