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Review Article Open Access
Volume 3 | Issue 1 | DOI: https://doi.org/10.46439/allergy.3.031

Why are men more severely affected by COVID-19?

  • 1SUNY Downstate Medical Center, Department of OB/GYN 450 Clarkson Avenue, Brooklyn, 11203 NY, USA
+ Affiliations - Affiliations

Corresponding Author

Sadia Alam, sadia.alam@downstate.edu

Received Date: July 30, 2022

Accepted Date: August 16, 2022

Abstract

The Coronavirus Disease (COVID-19) pandemic has claimed over a million deaths, with more men suffering from the serious consequences of disease compared to women. Not only have more men been dying from COVID but more men have also been reported to be in the Intensive Care Unit (ICU) with COVID related complications. In this literature review, we summarize this data across countries and cite several factors that influence men and women’s varying responses to COVID-19, including the effects of hormones on immunity and the differences in lifestyle and gendered habits. Estrogen in women has been consistently shown to play a protective role in the immune reaction against COVID-19 by down-regulating Angiotensin Converting Enzyme 2, the receptor used by SARS-COV-2 for entry into cells. However, adequate levels of testosterone are also required to mount any immune response in males. Further, the association between comorbidities and gender stratified COVID mortality is still unclear, but increased rates of smoking and delayed health care seeking have been shown to play a negative role in how men are affected. Looking forward, further isolating how estrogen and testosterone alterations affect immune responses to COVID-19 is important, as it can provide an avenue for effective therapeutics against COVID-19 complications.

Keywords

COVID-19, Immune function, Gender, Estrogen, Testosterone, Comorbidities

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