Archives of Autoimmune Diseases

Research Article Open Access

Adiponectin receptor fragmentation in mouse models of type 1 and type 2 diabetes

Dylan Frabutt, Natalie Stull, Annie R. Pineros, Sarah A. Tersey, Donalyn Scheuner, Teresa L. Mastracci, Michael J. Pugia

The protein hormone adiponectin regulates glucose and fatty acid metabolism by binding to two PAQR-family receptors (AdipoR1 and AdipoR2). Both receptors feature a C-terminal segment which is released by proteolysis to form a freely circulating C-terminal fragment (CTF) found in the plasma of normal individuals but not in some undefined diabetes patients.

Arch Autoimmune Dis, 2020, Volume 1, Issue 1, p3-13 | DOI: 10.46439/autoimmune.1.002

Research Article Open Access

Utilization of electronic health records for the assessment of adiponectin receptor autoantibodies during the progression of cardio-metabolic comorbidities

Michael J. Pugia, Meeta Pradhan, Rong Qi, Doreen L. Eastes, Anna Vorsilak, Bradley J. Mills, Zane Baird, Aruna Wijeratne, Scott M. McAhren, Amber Mosley, Anantha Shekhar, Daniel H. Robertson

Diabetes is a complex, multi-symptomatic disease whose complications drives increases in healthcare costs as the diabetes prevalence grows rapidly world-wide. Real-world electronic health records (EHRs) coupled with patient biospecimens, biological understanding, and technologies can characterize emerging diagnostic autoimmune markers resulting from proteomic discoveries.

Arch Autoimmune Dis, 2020, Volume 1, Issue 1, p17-27 | DOI: 10.46439/autoimmune.1.004