Archives of Stem Cell and Therapy

Case Report Open Access

Stem cell secretome-mediated alleviation of scalp psoriasis: A case report

Anjum Mahmood , Naman Somani , Divyang Patel , Rangnath Mishra , Anand Srivastsva

Scalp psoriasis, a skin condition characterized by red, thickened (erythematous), well-demarcated patches or plaques with overlying silvery-white scales, affecting part or all of the scalp, is an autoimmune disease accompanied by itchy skin. The disease is associated with faulty functioning of adaptive and innate components of immune systems. The key pro- inflammatory cytokines mediating immunopathology of psoriasis are IL-17 and IL-23 which promote proliferation of Th 17 cells which in turn induce proliferation of keratinocytes leading to the disease.

Review Article Open Access

Advancing towards HIV-1 remission: Insights and innovations in stem cell therapies

Aditi Chatterjee , Aerielle Matsangos , Olga S. Latinovic , Alonso Heredia , Giovannino Silvestri

Human immunodeficiency virus type 1 (HIV-1) continues to pose a significant global health challenge despite advances in combined antiretroviral therapy (cART), which has transformed HIV-1 infection from a fatal disease to a manageable chronic condition. However, cART is not curative, and its long-term use is associated with challenges such as pill burden, drug toxicities, and the emergence of drug-resistant viral strains.

Commentary Open Access

Neural circuit regulation of postnatal and adult subventricular zone neurogenesis: Mechanistic insights, functional models, and circuit-based neurological disorders

Moawiah M Naffaa

Neural circuits' role in regulating neurogenesis within the adult subventricular zone (SVZ) of the lateral ventricles (LV) has been extensively studied over the past two decades. The dynamic interplay between neurons, neurotransmitters, and LV neural stem cells (NSCs) highlights the critical influence of neural circuits on NSC renewal, proliferation, and differentiation.

Review Article Open Access

From molecular mechanisms to precision medicine: Transformative approaches in cirrhosis management

Tamer A. Addissouky

The rising prevalence of cirrhosis has become a significant global health concern. Cirrhosis is a leading cause of morbidity and mortality worldwide, contributing to a substantial burden on healthcare systems and economies.

Review Article Open Access

Bioengineering Providing Tailor-Made Products

Harsharan Singh

Bioengineering is a new discipline of science that apply engineering principles and techniques on the biological process for development of valuable bioactive molecule, designing metabolites and changing cells or cellular metabolites to combat the current as well as future challenges and problem of mankind. This is one of the most challenging fields testing the researcher’s intelligence, dedication, skill and creativity and courage needed to contradict convention and cut new pathways through unexplored scientific terrain.