Archives of Stem Cell and Therapy

Editorial Open Access

Recent discoveries in stem cell therapy: Charting new territories in regenerative medicine

Prerna Mehta

The regenerative medicine landscape is undergoing its fastest change due to the breakthroughs in stem cell therapy. The versatility of stem cells places them at the frontline of medical research with a promise of the possibilities of treating numerous diseases, both degenerative and traumatic. 

Arch Stem Cell Ther, 2025, Volume 6, Issue 1, p1-2 | DOI: 10.46439/stemcell.6.024

Commentary Open Access

Stem cell–based strategies for HIV-1 remission: Emerging frontiers and translational challenges

Aditi Chatterjee , Giovannino Silvestri

Antiretroviral therapy (ART) has transformed HIV-1 from a fatal infection into a manageable chronic condition. Yet ART cannot eradicate latent viral reservoirs, necessitating lifelong adherence and leaving more than 38 million people worldwide without a definitive cure [1].

Arch Stem Cell Ther, 2025, Volume 6, Issue 1, p3-5 | DOI: 10.46439/stemcell.6.025

Literature Review Open Access

COL2A1 mutations and type II collagenopathies: molecular mechanisms and iPSC-based modeling of cartilage disorders 

Latifa Mohammed Aljuid , Dareen Alyousfi , Manal Hosawi , Ayman Z. Elsamanoudy

Type II collagen (COL2A1) is the principal structural protein of cartilage and is crucial for maintaining extracellular matrix integrity during skeletal development. Pathogenic variants in COL2A1 disrupt collagen folding, secretion, and fibrillar assembly, leading to defective cartilage architecture and impaired chondrocyte maturation. These molecular alterations underline a broad group of autosomal dominant skeletal disorders collectively known as type II collagenopathies.

Arch Stem Cell Ther, 2025, Volume 6, Issue 1, p6-24 | DOI: 10.46439/stemcell.6.026