Abstract
Metal neurotransmitter interaction has well expanded role due to their direct relation with neurodegenerative diseases. Among this copper dopamine coupling is well studied because of the biochemical and redox interplay between copper ions and dopamine, where copper regulates dopamine metabolism while dopamine can chelate and redox-cycle copper. Disturbances in copper homeostasis directly influence dopamine metabolism, promoting oxidative stress, neuronal signaling & neurodegeneration. Cu-Dopa interaction alternatively could be used as mutual sensing probe for each other enhancing the sensitivity for developing next generation brain monitoring sensors. Hence this integrated approach is discussed over here which could enable earlier detection and more personalized management of neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases.