Health Care worker (HCW) infection with corona virus disease 2019 (COVID-19) is a serious problem and is generally attributed to transmission from patients with COVID-19 infection. There are now recommendations for best practices to limit such transmission. However, there are additional concerns regarding HCW infection with COVID-19, those of transmission of the infection from one HCW to another. This is suggested by a recent prospective cohort study that found 44% of frontline HCWs showed evidence of SARS-CoV-2 infection by reverse transcriptase polymerase chain reaction (RT-PCR) or serology. This higher prevalence of the infection among HCWs could be from transmission of the infection between one another during general and professional interactions in non-patient care settings such as hospital corridors or classrooms. The HCWs may adhere to required guidelines with personal protective equipment (PPE) when attending to patients but may be lax during the above interactions. Furthermore, it may be difficult to maintain social distancing. Viral transmission during pre-symptomatic and asymptomatic stages compounds the problem. Although PPE may be protective, adequate availability of PPE does not seem to completely reduce risk. Hence the current commentary attempts to address this issue and suggests that health-care systems should develop additional strategies to protect HCWs from the infection. Potential risk of false negative test results with RT-PCR especially in early stages of the disease precludes routine screening of HCWs as a solution to address the additional concerns. While successful vaccines have been developed, emerging variants are posing a problem. Hence, universal and strict use of triple layered surgical mask or N95 mask along with face shields for all hospital staff members from entry to exit from the hospital appears to be only logical preventive strategy as of now.