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Journal of Allergy and Infectious Diseases

ISSN: 2692-6334

Research Article Open Access
Volume 5 | Issue 1 | DOI: https://doi.org/10.46439/allergy.5.041

Dominated respiratory infections which exacerbate asthma in asthmatic children

Ali Mirhosseini1,#, Hamid Ahanchian2,#, Samira Basharkhah2, Amir Hashem Asnaashari3, Faezeh Sabet2, Fatemeh Sadat Mohammadi1, S.A Rahim Rezaee2,*
  • #These authors work equally
  • 1Inflammation and Inflammatory Diseases Division, Immunology Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
  • 2Allergy Research Center, Ghaem Hospital, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
  • 3Internal Dept, Respiratory ward, Ghaem Hospital, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
+ Affiliations - Affiliations

Corresponding Author

S.A Rahim Rezaee, Rezaeer@mums.ac.ir

Received Date: November 22, 2023

Accepted Date: December 29, 2023

Citation:

Mirhosseini A, Ahanchian H, Basharkhah S, Asnaashari AH, Sabet F, Mohammadi FS, et al. Dominated respiratory infections which exacerbate asthma in asthmatic children. Allergy Infect Dis. 2024;5(1):9-16.


Copyright: © 2024 Mirhosseini A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Microbes can influence development and trigger asthma attacks. Therefore, this study evaluated the more dominant microbial infections that trigger attacks in children.

Methods: Forty-one nasopharyngeal and oro-pharyengeal swabs were obtained from the Pediatric Allergy Clinic of two educational hospitals and sent to a Molecular Laboratory to evaluate 21 bacterial and viral respiratory pathogens using the qPCR-TaqMan method.

Results: The main bacterial infections were S. aureus (S. aur) 18/41 (43.9%), S. pneumoniae (S. pneu) 16/41 (39%), C. pneumoniae (C. pneu) 12 /41 (29.3%), and Haemophilus influenza Type B (HIB) 17/41 (41.5%) while the most viral infections were Human Respiratory Syncytial Virus (HRSV) 3/41 (7.3%) and Influenza type B (Flu.B), HRV, Human Metapneumoviruses (HMPVA.B), Human Para-Influenza Viruses (HPIV)-2,3,4, Human Coronaviruses (HcoV)-63, and HcoV-229 in 2 cases (4,9%), in asthmatic children. Although bacterial infections were more common in both genders, the agents' frequency was statistically different between girls and boys (P=0.02). There was a positive correlation between S. pneu infection, asthma attack, and bronchitis (P= 0.02 and P= 0.001, respectively). Furthermore, a positive correlation was found between AV and RSVA.B infections with allergic rhinitis (P= 0.02 and P= 0.001, respectively).

Conclusion: In conclusion, bacterial respiratory infections, particularly, HIB, S. aur and S. pneu, were more common; however, HRSV and Flu. B has been a dominant viral infection in asthmatic attacks.

Keywords

Asthma, Bacterial, Viral infections, Allergy

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