A logic model was developed as part of an evaluation of a case management program (CMP) for frequent users in a health and social services center in the province of Québec (Canada). Five approaches were used as part of a qualitative multiple case study methodology: analysis of unpublished documents, review of literature on CMPs for frequent users, in-depth interviews, focus groups with stakeholders and participant observations. Collected data were analyzed using thematic analysis and validated by the health and social services center’s partners.

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairments that might be accompanied by declines in activities of daily living, neuropsychiatric disorders and a loss of motor function [1,2]. At present, the prevalence of dementia of Alzheimer’s type (DAT) is approximately 4% among elderly people [3]. With the increase in the aging the population, the number of individuals with DAT is still increasing.

Breathing instruction in physiotherapy is considered an important skill for the assessment and intervention in diaphragmatic dysfunction associated with respiratory disorders. For respiratory physiotherapy, it is necessary to understand the characteristics of respiratory movements in the thorax and abdomen and to evaluate the laterality and difference in movements depending on the site.

Epigenetics is the study of heritable modifications to gene expression, such as DNA methylation, histone modifications, and RNA modifications, that do not alter the nucleotide sequence of the corresponding gene. Recently, RNA modification has emerged as a novel research focus. We have detected over 170 different RNA modifications,  such as N6-methyladenosine (m6A), N7-methylguanosine (m7G), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N3-methylcytosine (m3C), and pseudouridine (ψ).These modifications are important for biological processes like RNA metabolism and post-transcriptional regulation. 

In prior work, we analyzed gene expression profiles of mouse, rat and human gastrocnemius muscles to identify conserved regulators of muscle aging processes. By further comparing data obtained from different muscles we found stronger conservation of aging-related factors at the level of molecular pathways than at the level of individual genes.