Ewing sarcoma (ES) is an aggressive pediatric bone tumor that is prone to metastasis. Due to low five-year survival rates and limited therapeutic options for metastatic disease, there is a dire clinical need for improved ES treatments. Targeting p21-activated kinases (PAKs) may be key. PAK1 and PAK4 are associated with aggressive ES and poor patient outcomes, although their molecular mechanisms remain largely uncharacterized in this disease.

The incidence of breast cancer (BC) worldwide is on the rise due to reasons such as late detection, limited treatment choices for certain BC subtypes, and the development of drug resistance. These factors combined lead to unfavorable clinical results. Recent studies highlight the crucial significance of epigenetic changes in the development of BC, especially in relation to medication resistance and the preservation of stemness traits. Continuing research in the field of epigenetics and breast cancer carcinogenesis is crucial for overcoming present challenges and advancing our knowledge in this area, ultimately resulting in better outcomes for patients.

SARS-CoV-2 infection causes COVID-19, which has emerged as a health emergency worldwide. SARS-CoV-2 infects cells by binding to ACE2 receptors and enters into the cytoplasm following its escape from endolysosomes. Once in the cytoplasm, the virus replicates and eventually causes various pathological conditions including acute respiratory distress syndrome (ARDS) that is caused by pro-inflammatory cytokine storms.

Ferroptosis is a type of cell death caused by iron-dependent lipid peroxidation. In recent years, certain isoforms of glutathione-S-transferases (GSTs) have been identified that may play a key role in regulating ferroptosis. Previous study demonstrated that the NRF2/GSH/GST/RLIP76 and MRP1 axis acts as an independent anti-ferroptosis pathway. Furthermore, this study evaluated the therapeutic potential of mifepristone (RU486) for mitigating acetaminophen (APAP)-induced liver injury in vivo.