Mini Review Open Access
Volume 5 | Issue 1 | DOI: https://doi.org/10.46439/cancerbiology.5.058
The many faceted role of glycogen synthase kinase-3 (GSK-3) in T cells and cancer immunotherapy
Aurora Rivas Crespo1-3,4, Silvia Guil Luna1-3, Bastien Moës4,5, Antonio Rodriguez1-3, Christopher E Rudd4-6,*
- 1Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Córdoba, Spain
- 2Cancer Network Biomedical Research Centre (CIBERONC), Madrid, Spain
- 3Andalusia-ROCHE Network Mixed Alliance in Precision Medical Oncology, Spain
- 4Division of Immunology-Oncology, Centre de Recherche Hôpital Maisonneuve-Rosemont (CR-HMR), Montreal, QC, Canada
- 5Faculty of Medicine, Université de Montreal, Montreal, Canada
- 6Department of Microbiology, Infection and Immunology, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada
Corresponding Author
Christopher E Rudd, christopher.e.rudd@umontreal.ca
Received Date: January 02, 2024
Accepted Date: April 12, 2024
Crespo AR, Luna SG, Moës B, Rodriguez A, Rudd CE. The many faceted role of glycogen synthase kinase-3 (GSK-3) in T cells and cancer immunotherapy. J Cancer Biol. 2024;5(1):11-16.
Copyright: © 2024 Crespo AR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium,provided the original author and source are credited.
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The many faceted role of glycogen synthase kinase-3 (GSK-3) in T cells and cancer immunotherapy
Originally identified for its involvement in phosphorylating glycogen synthase and regulating glucose metabolism in response to insulin, glycogen synthase kinase-3 (GSK-3) has since been recognized as a versatile serine/threonine kinase with diverse functions [1,2]. Extensive research has demonstrated that GSK-3 phosphorylates over 100 protein substrates where it intersects numerous signaling pathways. While it was initially implicated in the regulation of glucose metabolism, subsequent investigations revealed an impact of GSK-3 in cellular processes beyond glycogen synthase phosphorylation and glycogen metabolism [3].