Objective: To investigate and compare the relationship between self-reported oral and general health among Indigenous and non-Indigenous Australians.
Methods: Data was obtained from two studies: study 1 was a convenience study of Indigenous Australians aged 18+ years residing in South Australia, and study 2 was a representative of Australians aged 15+ years in South Australia. Descriptive analyses were conducted to compare self-rated oral and general health-related quality of life, which was measured by calculating disutility scores with the five individual EQ-5D dimensions (EuroQol instrument: EQ-5D-5L).
Results: The sample comprised 1,011 and 2,891 Indigenous and non-Indigenous South Australian adults in study 1 and 2, respectively. A higher proportion of poor self-rated oral health and higher mean disutility score was observed among Indigenous than in non-Indigenous Australians, 33.5% vs. 9.5%, and 0.18 vs. 0.09, respectively. A higher mean disutility score was observed among Indigenous adults with poor self-rated oral health (0.25, 95% CI: 0.22-0.27) than among non-Indigenous adults with poor self-rated oral health (0.16, 95% CI: 0.14-0.18). After adjusting for social-demographic and health-related behaviors, the prevalence ratio was more than 2 times higher among Indigenous than in non-Indigenous Australians across each individual EQ-5D dimension. 
Conclusion: Our findings indicate that poor self-rated oral and general health-related quality of life persists among Indigenous relative to non-Indigenous Australians. The social determinants of health are likely to be root causes. Interventions that address social, economic and political constructs are required to reduce oral and general health inequalities between Indigenous and non-Indigenous Australians.

Indigenous Australians, EuroQol (EQ-5D-5L), Disutility score, Self-rated health