Multiple sclerosis (MS) is central nervous system (CNS) based disease. It is a chronic inflammatory demyelinating disease [1]. The main causes for MS are genetic and environmental factors. It is a disease of young people (median age of onset is around 28 years) but is lifetime and is often disabling; 50% of patients need a cane to walk 15 years after disease onset; and Worldwide more than 2.5 Million persons are affected.

There is a striking likeness between an old model for the action of mobile genetic elements in Maize and recent observations on endogenous retroviruses in human Multiple Sclerosis. Nexø discussed this and other developments in his recent theory on autoimmunity. Specifically, in analogy to the onc genes Nexø suggest that insertion of a retrovirus activates a so-called aut gene. This aut gene may well be an EBV genome. 

Retroviruses and EBV have been championed by different schools of thought as inducers of autoimmunity. The present theory suggests ending this competition between schools: They are both right. The viruses synergize! Probably, they even form a hybrid genome.

Intravascular large B-cell lymphoma (IVLBCL) is a rare and specific variant of diffuse large B-cell lymphoma (DLBCL). Epstein-Barr virus (EBV)-positive IVLBCL is particularly rare and highly aggressive. Up to present, only a few cases of EBV-positive IVLBCL have been reported in the literature. Here, we would like to further explore its clinicopathological and molecular features to ensure the awareness and accurate diagnosis of this entity.

CNS myelination is a well-known biological phenomenon related to increase in action potential conduction speed and synaptic integration. Demyelination or abnormal myelination has been related to seizures and epilepsy either in patients or animal models. Although its role in fastening action potential propagation has been confirmed, few additional biological functions of CNS myelin has been described.