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Archives of Clinical Toxicology

ISSN: 2692-8280

Review Article Open Access
Volume 5 | Issue 1 | DOI: https://doi.org/10.46439/toxicology.5.020

Acute, genetic, and target organ toxicity profiling of Frankincense essential oil from Boswellia sacra in zebrafish (Danio rerio)

Luay Rashan1,*, Thomas Efferth2, Muhammed Bishir3, Tousif Ahmed Hediyal3,4, Musthafa Mohamed Essa5,6, Saravana Babu Chidambaram3,4, M. Walid Qoronfleh7,8
  • 1Biodiversity Research Centre, Dohfar University, Salalah, Sultanate of Oman
  • 2Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany
  • 3Centre for Experimental Pharmacology and Toxicology, Central Animal Facility, JSS Academy of Higher Education & Research, Mysuru, India
  • 4Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, India
  • 5Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman
  • 6Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman
  • 7Q3CG Research Institute (QRI), Research & Policy Division, 7227 Rachel Drive, Ypsilanti, MI 48917, USA
  • 821, Health Street, Consulting Services, 1 Christian Fields, London, SW16 3JY, United Kingdom
+ Affiliations - Affiliations

Corresponding Author

Luay Rashan, luayrashan@yahoo.com

Received Date: April 05, 2023

Accepted Date: April 24, 2023

Citation:

Rashan L, Bishir M, Hediyal TA, Essa MM, Efferth T, Chidambaram SB, et al. Acute, genetic, and target organ toxicity profiling of Frankincense essential oil from Boswellia sacra in zebrafish (Danio rerio). Arch Clin Toxicol. 2023;5(1):12-21.


Copyright: © 2023 Rashan L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Frankincense oil is widely used across the globe for various therapeutic implications. However, the potential toxicity profile of Frankincense oil has not been well explored. The present study is a debut attempt to study the organ-specific (cardiac, hepatic, and neuromuscular) toxicity profile of Frankincense essential oil from Boswellia sacra using the zebrafish embryo model. The results revealed a “no observed effect concentration” (NOEC) dose of Frankincense oil of 300 µg/ml. Signs of cardiac toxicity were not observed if the zebrafish embryos were incubated with Frankincense oil (100 µg/ml). In addition, signs of genotoxicity were also not observed at the same concentration. Similarly, neuromuscular toxicity evaluated by the locomotor activity in the presence of light and hepatic toxicity measured by liver size, yolk retention, and steatosis were not found. Despite the absence of toxic effects of Frankincense oil on zebrafish embryo survival, it should be further investigated to assess if the prolonged administration of Frankincense oil in higher vertebrates might induce potential toxic effects.

Keywords

Frankincense oil, Zebrafish, Acute toxicity, Genetic toxicity, Systemic toxicity

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Acute, genetic, and target organ toxicity profiling of Frankincense essential oil from Boswellia sacra in zebrafish (Danio rerio)

Frankincense oil is widely used across the globe for various therapeutic implications. However, the potential toxicity profile of Frankincense oil has not been well explored. The present study is a debut attempt to study the organ-specific (cardiac, hepatic, and neuromuscular) toxicity profile of Frankincense essential oil from Boswellia sacra using the zebrafish embryo model. The results revealed a “no observed effect concentration” (NOEC) dose of Frankincense oil of 300 µg/ml. Signs of cardiac toxicity were not observed if the zebrafish embryos were incubated with Frankincense oil (100 µg/ml). 

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